Compounds for use in treatment of mucositis
The present invention provides methods for treating and/or preventing mucostitis with one or more compounds, or pharmaceutically acceptable salts thereof, disclosed herein, or compositions comprising the same.
1. A method of treating or preventing mucositis in a human comprising administering an oral, buccal, or sublingual pharmaceutical composition to the human in need thereof, wherein the pharmaceutical composition comprises a compound having the formula
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the pharmaceutical composition is a rinse.
3. The method of claim 1 , wherein the pharmaceutical composition further comprises an analgesic.
4. The method of claim 1 , wherein the pharmaceutical composition further comprises an antibiotic.
5. The method of claim 1 , wherein the pharmaceutical composition further comprises palifermin.
6. The method of claim 1 , wherein the human also receives chemotherapy, radiation therapy, or both, for the treatment of cancer.
7. The method of claim 1 , wherein the human also receives high-dose chemotherapy prior to hematopoietic cell transplantation.
8. The method of claim 1 , wherein the human also receives radiation therapy for a tumor of the head and neck.
9. The method of claim 1 , wherein the human also receives induction therapy for leukemia.
10. The method of claim 1 , wherein the human also receives conditioning regimens for bone marrow transplant.
11. The method of claim 1 , wherein the human is experiencing basal epithelial cell death.
12. The method of claim 1 , wherein the mucositis is ulcerative oral mucositis.
13. The method of claim 1 , wherein the human is experiencing severe oral ulcerations.