Cardiac sarcomere inhibitors

1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof:

wherein:

G 1 is —CR 4 R 5 ;

G 2 is a bond;

G 3 is —CR 8 ;

R 1 , R 3 , R 4 , R 5 , and R 8 are each independently H, C 1 -C 6 alkyl, halo, or hydroxyl;

R 2 is H, C 2 -C 6 alkyl, halo, or hydroxyl;

Z is a bond

A is 5- or 6-membered heteroaryl comprising at least one annular N atom, wherein the 5- or 6-membered heteroaryl is unsubstituted or substituted with one or more R 10 substituents;

each R 10 is independently selected from the group consisting of substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 2 -C 6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, and —C(O)OR a ;

B is heteroaryl, wherein the heteroaryl of B is unsubstituted or substituted with one or more R 11 substituents;

each R 11 is independently selected from the group consisting of substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, unsubstituted C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with one or more R 12 substituents, substituted or unsubstituted C 2 -C 6 alkenyl, substituted or unsubstituted C 2 -C 6 alkynyl, halo, —OR b , —C(O)R c , —C(O)OR d , oxo, and —NR e R f ;

each R 12 is independently selected from the group consisting of halo, —OR b , —C(O)R g , —C(O)OR h , and —C(O)NR i R j ; and

each R a , R b , R c , R d , R e , R f , R g , R h , R i , and R j is independently H or C 1 -C 6 alkyl.

2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound of Formula (I) is a compound of Formula (If):

3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 8 are each H.

4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein G 1 is —CH 2 —.

5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein G 3 is —CH—.

6. The compound of claim 1 , wherein R 1 , R 2 , and R 3 are each H.

7. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is 5-membered heteroaryl comprising at least one annular N atom, wherein the 5-membered heteroaryl is unsubstituted or substituted with one or more R 10 substituents.

8. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is selected from the group consisting of pyrazolyl, oxazolyl, oxadiazolyl, isoxazolyl, tetrazolyl, triazolyl, thiazolyl, pyrimidinyl, pyridinyl, pyrazinyl, and pyridazinyl, each of which is unsubstituted or substituted with one or more R 10 substituents.

9. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is oxadiazolyl or isoxazolyl, each of which is unsubstituted or substituted with one or more R 10 substituents.

10. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is selected from the group consisting of:

each of which is unsubstituted or substituted with one or more R 10 substituents.

11. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each C 1 -C 6 alkyl, cycloalkyl, or heterocycloalkyl of R 10 is independently unsubstituted or substituted with one more substituents independently selected from the group consisting of —OR k and —OC(O)R m , wherein R k and R m are each independently H or C 1 -C 6 alkyl.

12. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 10 is independently selected from the group consisting of —C(O)OCH 3 , methyl, ethyl, isopropyl, difluoromethyl, cyclopropyl, cyclobutyl, and oxetanyl,

wherein each methyl, ethyl and isopropyl of R 10 is independently unsubstituted or substituted with one more substituents independently selected from the group consisting of —OCH 3 , —OH, and —OC(O)CH 3 .

13. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is oxadiazolyl, which is unsubstituted or substituted with one substituent selected from the group consisting of methyl, methyl substituted with —OCH 3 , —OH, or —OC(O)CH 3 , ethyl, ethyl substituted with —OCH 3 , —OH, or —OC(O)CH 3 , isopropyl, isopropyl substituted with —OCH 3 , —OH, or —OC(O)CH 3 , difluoromethyl, cyclopropyl, cyclobutyl, oxetanyl, and —C(O)OCH 3 .

14. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is oxadiazolyl, which is unsubstituted or substituted with one substituent selected from the group consisting of methyl, ethyl, isopropyl, difluoromethyl, cyclopropyl, and cyclobutyl.

15. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is isoxazolyl, which is unsubstituted or substituted with one or more substituents selected from the group consisting of methyl, ethyl, and difluoromethyl.

16. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is isoxazolyl, which is unsubstituted or substituted with one substituent selected from the group consisting of methyl, ethyl, and difluoromethyl.

17. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein A is selected from the group consisting of:

wherein each R 13 is independently selected from the group consisting of H, substituted or unsubstituted C 1 -C 6 alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, and —C(O)OR a ; and R a is H or C 1 -C 6 alkyl.

18. The compound of claim 17 , or a pharmaceutically acceptable salt thereof, wherein each R 13 is independently selected from the group consisting of H, —C(O)OCH 3 , methyl, ethyl, isopropyl, difluoromethyl, cyclopropyl, cyclobutyl, and oxetanyl,

wherein each methyl, ethyl and isopropyl of R 13 is independently unsubstituted or substituted with one more substituents independently selected from the group consisting of —OCH 3 , —OH, and —OC(O)CH 3 .

19. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein B is 5- or 6-membered heteroaryl, wherein the 5- or 6-membered heteroaryl of B is unsubstituted or substituted with one or more R 11 substituents;

each R 11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, cycloalkyl, aryl, C 1 -C 6 alkyl, halo, fluoroalkyl, —OR b , —C(O)R c , —C(O)OR d , oxo, and —NR e R f , wherein each heterocycloalkyl and heteroaryl of R 11 is unsubstituted or substituted with one or more substituents selected from the group consisting of C 1 -C 6 alkyl, —C(O)R n , —C(O)OR p , and —C(O)NR q R r ; and

each R b , R c , R d , R e , R f , R n , R p , R q , and R r is independently H or C 1 -C 6 alkyl.

20. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein B is 5- or 6-membered monocyclic heteroaryl comprising at least one annular N atom or 8- or 9-membered bicyclic heteroaryl comprising at least one annular N atom, each of which is substituted or unsubstituted.

21. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein B is 5- or 6-membered monocyclic heteroaryl comprising at least one annular N atom or 8- or 9-membered bicyclic heteroaryl comprising at least one annular N atom, each of which is unsubstituted or substituted with one or more R 11 substituents;

each R 11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, cycloalkyl, aryl, C 1 -C 6 alkyl, halo, fluoroalkyl, —OR b , —C(O)R c , —C(O)OR d , oxo, and —NR e R f , wherein each heterocycloalkyl and heteroaryl of R 11 is unsubstituted or substituted with one or more substituents selected from the group consisting of C 1 -C 6 alkyl, —C(O)R n , —C(O)OR p , and —C(O)NR q R r , and wherein each C 1 -C 6 alkyl of R 11 is unsubstituted or substituted with —OR b ; and

each R b , R c , R d , R e , R f , R n , R p , R q , and R r is independently H or C 1 -C 6 alkyl.

22. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein B is selected from the group consisting of thiazolyl, triazolyl, imidazolyl, pyrazolyl, tetrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, pyrazinyl, pyridazinyl, pyrimidinyl, pyridinyl, pyrrolopyrazolyl and benzoimidazolyl, each of which is unsubstituted or substituted with one or more R 11 substituents;

each R 11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, cycloalkyl, aryl, C 1 -C 6 alkyl, halo, fluoroalkyl, —OR b , —C(O)R c , —C(O)OR d , oxo, and —NR e R f , wherein each heterocycloalkyl and heteroaryl of R 11 is unsubstituted or substituted with one or more substituents selected from the group consisting of C 1 -C 6 alkyl, —C(O)R n , —C(O)OR p , and —C(O)NR q R r , and wherein each C 1 -C 6 alkyl of R 11 is unsubstituted or substituted with —OR b ; and

each R b , R c , R d , R e , R f , R n , R p , R q , and R r is independently H or C 1 -C 6 alkyl.

23. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 11 is independently selected from the group consisting of methyl, ethyl, isopropyl, cyclopropyl, difluoromethyl, trifluoromethyl, oxo, —C(O)CH 3 , —C(O)OtBu, —OCH 3 , —OH, —NH 2 , —Cl, oxetanyl, oxadiazolyl, and azetidinyl, wherein each oxadiazolyl and azetidinyl of R 11 is unsubstituted or substituted with one or more substituents selected from the group consisting of ethyl, —C(O)CH 3 , —C(O)OtBu, —C(O)OCH 3 , —C(O)NHCH 3 , —C(O)NH 2 , and —OCH 3 , and wherein each methyl, ethyl, and isopropyl of R 11 is unsubstituted or substituted with —OH.

24. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein B is pyrazolyl, oxazolyl, tetrazolyl, isoxazolyl, thiazolyl, imidazolyl, or pyridinyl, each of which is unsubstituted or substituted with one or more R 11 substituents;

each R 11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, halo, C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with one or two R 12 substituents, cycloalkyl, cycloalkyl substituted with one or two R 12 substituents, fluoroalkyl, —OR b , —C(O)R c , —C(O)OR d , oxo, and —NR e R f ;

each R 12 is independently selected from the group consisting of halo, —OR b , —C(O)R g , —C(O)OR h , and —C(O)NR i R j ; and

each R b , R c , R d , R e , and R f , R g , R h , R i , and R j is independently H or C 1 -C 6 alkyl.

25. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein B is pyrazolyl, oxazolyl, tetrazolyl, isoxazolyl, thiazolyl, imidazolyl, or pyridinyl, each of which is unsubstituted or substituted with one or more R 11 substituents;

each R 11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, halo, C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with one or two R 12 substituents, cycloalkyl, cycloalkyl substituted with one or two R 12 substituents, fluoroalkyl, —OR b , oxo, and —NR e R f ;

each R 12 is independently selected from the group consisting of halo, —OR b , and —C(O)NR i R j ; and

each R b , R e , R f , R i , and R j is independently H or C 1 -C 6 alkyl.

26. The compound of claim 25 , or a pharmaceutically acceptable salt thereof, wherein R b is H.

27. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein B is selected from the group consisting of:

each of which is unsubstituted or substituted with one or more R 11 substituents;

each R 11 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, halo, C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with one or two R 12 substituents, cycloalkyl, cycloalkyl substituted with one or two R 12 substituents, fluoroalkyl, —OR b , —C(O)R c , —C(O)OR d , oxo, and —NR e R f ;

each R 12 is independently selected from the group consisting of halo, —OR b , —C(O)R g , —C(O)OR h , and —C(O)NR i R j ; and

each R b , R c , R d , R e , and R f , R g , R h , R i , and R j is independently H or C 1 -C 6 alkyl.

28. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein B is selected from the group consisting of:

wherein each R 14 is independently selected from the group consisting of heterocycloalkyl, heteroaryl, cycloalkyl, cycloalkyl substituted with one or two R 12 substituents, aryl, C 1 -C 6 alkyl, C 1 -C 6 alkyl substituted with one or two R 12 substituents, halo, fluoroalkyl, —OR b , —C(O)R c , —C(O)OR d , oxo, and —NR e R f , wherein each heterocycloalkyl and heteroaryl of R 14 is unsubstituted or substituted with one or more substituents selected from the group consisting of C 1 -C 6 alkyl, —C(O)R n , —C(O)OR p , and —C(O)NR q R r ;

each R 12 is independently selected from the group consisting of halo, —OR b , —C(O)R g , —C(O)OR h , and —C(O)NR i R j ; and

each R b , R c , R d , R e , R f , R g , R h , R i , and R j , R n , R p , R q , and R r is independently H or C 1 -C 6 alkyl.

29. A compound or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:

Structure

Name

2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2-methylisonicotinamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyl-1H-imidazole- 5-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyl-1H-pyrazole- 4-carboxamide;

2-chloro-N-(5-(5-(difluoromethyl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)thiazole-5-carboxamidc;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyloxazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methylthiazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)thiazole-5-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyloxazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyloxazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2-ethyl-5-methyl-2H- 1,2,3-triazole-4-carboxamide;

4-cyclopropyl-N-(5-(5- (difluoromethyl)-,1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2,5-dimethyloxazole-4- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-6-methylpyrazine-2- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2,6 dimethylisonicotinamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-3-ethyl-1-methyl-1H- pyrazole-4-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2-methylpyrimidine-4- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1,5-dimethyl-1H- pyrazole-4-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1,3-dimethyl-1H- pyrazole-4-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-ethyl-1H-pyrazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1,3-dimethyl-1H- pyrazole-5-carboxamide;

(R)-2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide;

(R)-2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2-methylisonicotinamide;

2-amino-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide;

3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isoxazole-5-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyl-1H-pyrazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5,6-dihydro-4H-pyrrolo[1,2- b]pyrazole-3-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-6-methylpyridazine-4- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylpyrazine-2- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylnicotinamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-3-(trifluoromethyl)-1H- pyrazole-4-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3,5-dimethylpyrazine-2- carboxamide;

2-hydroxy-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isonicotinamide;

2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-1,2,3-triazole-4-carboxamide;

1,2-dimethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-imidazole-5-carboxamide;

5-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-4-carboxamide;

1,3-dimethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide;

(R)-2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide;

4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide;

4-cyclopropyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide;

2,4-dimethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide;

1,5-dimethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide;

1,3-dimethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide;

1-ethyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide;

N-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-5,6- dihydro-4H-pyrrolo[1,2-b]pyrazole-3- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylpicolinamide;

3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)picolinamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazo1-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylthiazole-2-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,2-dimethyl-1H-imidazole-5- carboxamide;

1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3-(pyridin- 3-yl)urea;

4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)thiazole-2-carboxamide;

2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide;

1-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide;

(R)-1-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylpicolinamide;

4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)picolinamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1H-pyrazole-4- carboxamide;

3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1H-pyrazole-4- carboxamide

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methylisoxazole-4- carboxamide;

N-(5-(5-cyclopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1,3- dimethyl-1H-pyrazole-4-carboxamide;

(3-(1-(1,3-dimethyl-1H-pyrazole-4- carboxamido)-2,3-dihydro-1H-inden- 5-yl)-1,2,4-oxadiazol-5-yl)methyl acetate;

N-(5-(5-isopropyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,3- dimethyl-1H-pyrazole-4-carboxamide;

N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide;

(1S)-1-(3-(1-(1,3-dimethyl-1H- pyrazole-4-carboxamido)-2,3-dihydro- 1H-inden-5-yl)-1,2,4-oxadiazol-5- yl)ethyl acetate;

methyl 3-(1-(1,3-dimethyl-1H- pyrazole-4-carboxamido)-2,3-dihydro- 1H-inden-5-yl)-1,2,4-oxadiazole-5- carboxylate;

N-(5-(5-(hydroxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide;

N-(5-(5-((S)-1-hydroxyethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-1,2,3-triazole-4- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methyl-1,2,4-oxadiazole-3- carboxamide;

1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3-(pyridin- 4-yl)urea;

1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3- (pyrazin-2-yl)urea;

5-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,2,4-oxadiazole-3-carboxamide;

4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-5-carboxamide;

3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-4-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-5- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylisoxazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-hydroxyisonicotinamide;

1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3- (pyrimidin-5-yl)urea;

1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3- (pyridazin-3-yl)urea;

1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3- (pyrimidin-4-yl)urea;

2-amino-N-(5-(5-(difluoromethyl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyloxazole-5-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylisoxazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylisoxazole-3- carboxamide;

4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-3-carboxamide;

(R)-1,3-dimethyl-N-(5-(5-methyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide;

(R)-1-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide;

1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3-(pyridin- 2-yl)urea;

1-(5-(5-methyl-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1-yl)-3- (pyrimidin-2-yl)urea;

(R)-1,3-dimethyl-N-(5-(5-methyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide;

(R)-2,4-dimethyl-N-(5-(5-methyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)oxazole-5-carboxamide;

(R)-4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-5-carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylisoxazole-5- carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methylisoxazole-5- carboxamide;

(R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-4- methylisoxazole-5-carboxamide

(R)-4-methyl-N-(5-(5-(oxetan-3-yl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isoxazole-5-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-1,2,4-triazole-3- carboxamide;

1-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-1,2,4-triazole-3-carboxamide;

1-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-1,2,4-triazole-5-carboxamide;

N-((R)-5-(5-((S)-1-methoxyethyl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-4-methylisoxazole-5- carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1,2,4-oxadiazole-5- carboxamide;

3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,2,4-oxadiazole-5-carboxamide;

N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-4- carboxamide;

2-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)isonicotinamide;

(R)-2-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)isonicotinamide;

N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylisonicotinamide;

(R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylisonicotinamide;

2-methyl-N-(5-(2-methyloxazol-5-yl)- 2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-2-methyl-N-(5-(2-methyloxazol-5- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-2-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide;

2-methyl-N-(5-(5-methylisoxazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-2-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-2-methyl-N-(5-(5-methyloxazol-2- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

2-methyl-N-(5-(5-methyloxazol-2-yl)- 2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide;

(R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2- methyl-2H-tetrazole-5-carboxamide;

(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide;

2-methyl-N-(5-(2-methyloxazol-4-yl)- 2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-2-methyl-N-(5-(2-methyloxazol-4- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-2-methyl-N-(5-(2-methyl-2H- tetrazol-5-yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

2-methyl-N-(5-(2-methyl-2H-tetrazol- 5-yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(S)-2-methyl-N-(5-(2-methyl-2H- tetrazol-5-yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1,3- dimethyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide;

(R)-4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4H-1,2,4-triazole-3-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyl-4H-1,2,4-triazole-3- carboxamide;

N-(5-(5-(difluoromethyl)isoxazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide;

(R)-N-(5-(5-(difluoromethyl)isoxazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide;

N-(5-(3-(difluoromethyl)isoxazol-5- yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide;

(R)-N-(5-(3-(difluoromethyl)isoxazol- 5-yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide;

(R)-2-methyl-N-(5-(4-methyloxazol-2- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

2-methyl-N-(5-(4-methyloxazol-2-yl)- 2,3-dihydro-1H-inden-1- yl)isonicotinamide;

1-methyl-N-((1R)-5-(5-(oxetan-2-yl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-5- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylisonicotinamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyloxazole-5-carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-5- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2,4-dimethyloxazole-5- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methyl-2H-tetrazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-tetrazole-5- carboxamide;

(R)-1,3-dimethyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide;

(R)-1,3-dimethyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide;

(R)-2-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide;

(R)-2-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide;

(R)-1-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-5-carboxamide;

(R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-5- carboxamide;

(R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1,3-dimethyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyloxazole-5-carboxamide;

(R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide;

(R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-5- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-5-carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-5- carboxamide;

(R)-1-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide;

(R)-2-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2H-tetrazole-5- carboxamide;

(R)-1-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide;

(R)-2-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide;

(R)-1,3-dimethyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide;

(R)-1,3-dimethyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide;

(R)-4-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isoxazole-5-carboxamide;

(R)-2-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)oxazole-5-carboxamide;

(R)-1,5-dimethyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide;

(R)-4-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)oxazole-5-carboxamide;

(R)-2-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2H- tetrazole-5-carboxamide;

(R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-2-methyl-2H- tetrazole-5-carboxamide;

(R)-N-(5-(3-ethyl-1,2,4-oxadiazol-5- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(3-ethyl-1,2,4-oxadiazol-5- yl)-2,3-dihydro-1H-inden-1-yl)-1,5- dimethyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(3-ethyl-1,2,4-oxadiazol-5- yl)-2,3-dihydro-1H-inden-1-yl)-2- methyl-2H-tetrazole-5-carboxamide;

(R)-N-(5-(3-ethyl-1,2,4-oxadiazol-5- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-5-carboxamide;

(R)-N-(5-(3-cyclopropyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(3-cyclopropyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(3-cyclopropyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyl-2H-tetrazole-5- carboxamide;

(R)-N-(5-(3-cyclopropyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-5- carboxamide;

(R)-1-methyl-N-(5-(3-methyl-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide;

(R)-1,5-dimethyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide;

(R)-2-methyl-N-(5-(3-(methyl-d3)- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-2H-tetrazole-5- carboxamide;

(R)-1-methyl-N-(5-(3-(methyl-d3)- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide;

(R)-1-methyl-N-(5-(3-(methyl-d3)- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide;

(R)-4-methyl-N-(5-(3-(methyl-d3)- 1,2,4-oxadiazol-5-yl)-2,3-dihydro-1H- inden-1-yl)isoxazole-5-carboxamide;

(R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(3-(difluoromethyl)-1,2,4- oxadiazol-5-yl)-2,3-dihydro-1H-inden- 1-yl)-1,5-dimethyl-1H-pyrazole-4- carboxamide;

(R)-1-methyl-N-(5-(pyrimidin-2-yl)- 2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide;

(R)-1-methyl-N-(5-(pyridin-2-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 5-carboxamide;

(R)-1-methyl-N-(5-(pyrazin-2-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 5-carboxamide;

(R)-1-methyl-N-(5-(pyridazin-4-yl)- 2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide;

(R)-1-methyl-N-(5-(thiazol-2-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 5-carboxamide;

(R)-1-methyl-N-(5-(5-methylthiazol-2- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide;

(R)-1-methyl-N-(5-(6-methylpyridin- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide;

(R)-1-methyl-N-(5-(5-methylpyridin- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide;

(R)-1-methyl-N-(5-(6-methylpyridin- 2-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide;

(R)-1-methyl-N-(5-(4- methylpyrimidin-2-yl)-2,3-dihydro- 1H-inden-1-yl)-1H-pyrazole-5- carboxamide;

(R)-1-methyl-N-(5-(2- methylpyrimidin-4-yl)-2,3-dihydro- 1H-inden-1-yl)-1H-pyrazole-5- carboxamide;

(R)-1-methyl-N-(5-(4-methylpyridin- 2-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide;

(R)-1-methyl-N-(5-(6- methylpyrimidin-4-yl)-2,3-dihydro- 1H-inden-1-yl)-1H-pyrazole-5- carboxamide;

(R)-1-methyl-N-(5-(6-methylpyrazin- 2-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide;

(R)-1-methyl-N-(5-(5- methylpyridazin-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide;

(R)-1-methyl-N-(5-(6- methylpyridazin-4-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-5- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methyloxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-4- methyloxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyloxazole-5-carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylisonicotinamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyloxazole-5-carboxamide;

(R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2- methyloxazole-5-carboxamide;

(R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2- methylisonicotinamide;

(R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-4- methyloxazole-5-carboxamide;

(R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-3- methyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1H-pyrazole-4- carboxamide;

(R)-3-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide;

(R)-3-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide;

(R)-1-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide;

(R)-1-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide;

(R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-2- methylisonicotinamide;

(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyloxazole-5-carboxamide;

(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methyloxazole-5-carboxamide;

(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylisonicotinamide;

(R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1-methyl-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1-methyl-1H- pyrazole-5-carboxamide;

(R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-2- methyloxazole-5-carboxamide;

(R)-2-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide;

(R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-4- methyloxazole-5-carboxamide;

(R)-4-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-ethylisoxazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-5-methyl-1H- pyrazole-4-carboxamide;

(R)-5-methyl-N-(5-(5-methylisoxazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyloxazole-5-carboxamide;

(R)-4-methyl-N-(5-(5-methyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)oxazole-5-carboxamide;

(R)-1-methyl-N-(5-(5-(1- methylcyclopropyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-5-carboxamide;

N-((1R)-5-(5-(2,2- dimethylcyclopropyl)-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-5-carboxamide;

(R)-2-methyl-N-(5-(5-(1- methylcyclopropyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- (methoxymethyl)oxazole-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- ((methylsulfonyl)methyl)oxazole-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- (oxetan-3-yl)-1H-pyrazole-4- carboxamide;

tert-butyl (R)-3-(4-((5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- yl)carbamoyl)-1H-pyrazol-1- yl)azetidine-1-carboxylate;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-1H-pyrazole-4- carboxamide;

methyl (R)-2-(4-((5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)carbamoyl)-1H-pyrazol-1- yl)acetate;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-1H-pyrazole-4- carboxamide;

(R)-1-(2-amino-2-oxoethyl)-N-(5-(5- ethyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxy-2-methylpropyl)-1H- pyrazole-4-carboxamide;

(R)-1-(1-acetylazetidin-3-yl)-N-(5-(5- ethyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(1- (methylsulfonyl)azetidin-3-yl)-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(1- (methylcarbamoyl)azetidin-3-yl)-1H- pyrazole-4-carboxamide;

methyl (R)-3-(4-((5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)carbamoyl)-1H-pyrazol-1- yl)azetidine-1-carboxylate;

(R)-1-(1-carbamoylazetidin-3-yl)-N- (5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide;

5-(5-ethyl-1,2,4-oxadiazol-3-yl)-N-(1- methyl-1H-pyrazol-4-yl)-2,3-dihydro- 1H-indene-1-carboxamide;

5-(5-ethyl-1,2,4-oxadiazol-3-yl)-N-(2- methylpyridin-4-yl)-2,3-dihydro-1H- indene-1-carboxamide;

(R)-1-(azetidin-3-yl)-N-(5-(5-ethyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide;

1-(2,3-dihydroxypropyl)-N-((R)-5-(5- ethyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methoxy-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-methyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-(methyl-d3)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1H-pyrazole-4-carboxamide;

ethyl 2-(3-((R)-1-(1-methyl-1H- pyrazole-5-carboxamido)-2,3-dihydro- 1H-inden-5-yl)-1,2,4-oxadiazol-5- yl)propanoate;

ethyl 2-(3-(1-(2-methyloxazole-5- carboxamido)-2,3-dihydro-1H-inden- 5-yl)-1,2,4-oxadiazol-5-yl)propanoate;

(R)-2-(4-((5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)carbamoyl)-1H-pyrazol-1-yl)ethyl acetate;

N-((1S,2S)-5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2-hydroxy-2,3-dihydro-1H- inden-1-yl)-1-methyl-1H-pyrazole-4- carboxamide;

N-((lR)-5-(5-(1-hydroxypropan-2-yl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1-methyl-1H-pyrazole-5- carboxamide;

N-((R)-5-(5-((R)-1-hydroxypropan-2- yl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro- 1H-inden-1-yl)-1-methyl-1H-pyrazole- 5-carboxamide;

N-((R)-5-(5-((S)-1-hydroxypropan-2- yl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro- 1H-inden-1-yl)-1-methyl-1H-pyrazole- 5-carboxamide;

(R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-2H- tetrazole-5-carboxamide;

(R)-2-benzyl-N-(5-(5-isopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide;

(R)-2-benzyl-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2H- tetrazole-5-carboxamide;

(R)-2-benzyl-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide;

ethyl 2-(3-((R)-1-(2-methyl-2H- tetrazole-5-carboxamido)-2,3-dihydro- 1H-inden-5-yl)-1,2,4-oxadiazol-5- yl)propanoate;

(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2H-tetrazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- (oxetan-3-ylmethyl)-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-((3- methyloxetan-3-yl)methyl)-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-((3- fluorooxetan-3-yl)methyl)-1H- pyrazole-4-carboxamide;

(R)-1-(2-methoxyethyl)-N-(5-(5- methyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-methoxyethyl)-1H-pyrazole- 4-carboxamide;

(R)-N-(5-(5-isopropyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-1H-pyrazole-4- carboxamide;

(R)-1-(2-methoxyethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-methoxyethyl)-1H-pyrazole- 4-carboxamide;

(R)-1-(2-methoxyethyl)-N-(5-(5- (methyl-d3)-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide;

N-((1R)-5-(5-(1-hydroxypropan-2-yl)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-2-methyl-2H-tetrazole-5- carboxamide;

(R)-1-(2-hydroxyethyl)-N-(5-(5- (methyl-d3)-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide;

(R)-1-(2-hydroxyethyl)-N-(5-(5- methyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-1H-pyrazole- 4-carboxamide;

(R)-1-(2-hydroxyethyl)-N-(5-(5- isopropyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide;

(R)-1-(2-hydroxyethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1H- pyrazole-4-carboxamide;

N-(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-1H-pyrazole- 4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- vinyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-1H-pyrazole- 4-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-methoxyethyl)-1H-pyrazole- 4-carboxamide;

(R)-1-(2,2-dimethoxyethyl)-N-(5-(5- ethyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1-yl)-1H-pyrazole- 4-carboxamide;

2-(4-(((R)-5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)carbamoyl)-1H-pyrazol-1- yl)propanoic acid;

(R)-2-(4-((5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)carbamoyl)-1H-pyrazol-1-yl)acetic acid;

N-((R)-5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(1- hydroxypropan-2-yl)-1H-pyrazole-4- carboxamide;

N-((R)-5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxypropyl)-1H-pyrazole-4- carboxamide;

N-[(1R)-5-(5-ethyl(1,2,4-oxadiazol-3- yl))indanyl][1-((2R)-2,3- dihydroxypropyl)pyrazol-4- yl]carboxamide;

N-[(1R)-5-(5-ethyl(1,2,4-oxadiazol-3- yl))indanyl][1-((2S)-2,3- dihydroxypropyl)pyrazol-4- yl]carboxamide;

N-[(1R)-5-(5-ethyl(1,2,4-oxadiazol-3- yl))indanyl][1-((2S)-2- hydroxypropyl)pyrazol-4- yl]carboxamide;

N-[(1R)-5-(5-ethyl(1,2,4-oxadiazol-3- yl))indanyl][1-((2R)-2- hydroxypropyl)pyrazol-4- yl]carboxamide;

1-(3-{(1R)-1-[(1-methylpyrazol-4- yl)carbonylamino]indan-5-yl}(1,2,4- oxadiazol-5-yl))(1S)ethyl acetate;

methyl 2-(3-{(1R)-1-[(1- methylpyrazol-4- yl)carbonylamino]indan-5-yl}-1,2,4- oxadiazol-5-yl)acetate;

N-[1R)-5-(5-acetyl(1,2,4-oxadiazol-3- yl))indanyl](1-methylpyrazol-4- yl)carboxamide;

N-{(1R)-5-[5-(2-methoxyethyl)(1,2,4- oxadiazol-3-yl)]indanyl}(1- methylpyrazol-4-yl)carboxamide;

N-[(1R)-5-(5-vinyl(1,2,4-oxadiazol-3- yl))indanyl](1-methylpyrazol-4- yl)carboxamide;

2-(3-{(1R)-1-[(1-methylpyrazol-4- yl)carbonylamino]indan-5-yl}-1,2,4- oxadiazol-5-yl)ethylacetate;

N-{(1R)-5-[5-(hydroxyethyl)(1,2,4- oxadiazol-3-yl)]indanyl}(1- methylpyrazol-4-yl)carboxamide;

N-{(1R)-5-[5-((1R)-1- hydroxyethyl)(1,2,4-oxadiazol-3- yl)]indanyl}(1-methylpyrazol-4- yl)carboxamide;

N-{(1R)-5-[5-(methoxyethyl)(1,2,4- oxadiazol-3-yl)]indanyl}(1- methylpyrazol-4-yl)carboxamide;

N-{(1R)-5-[5-(2-hydroxyethyl)(1,2,4- oxadiazol-3-yl)]indanyl}(1- methylpyrazol-4-yl)carboxamide;

N-[(1R)-5-(5-ethyl(1,2,4-oxadiazol-3- yl))indanyl][1-(2,3- dihydroxypropyl)pyrazol-4- yl]carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-7-fluoro-2,3-dihydro-1H-inden-1- yl)-1-methyl-1H-pyrazole-4- carboxamide;

Ethyl (R)-4-((5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)carbamoyl)picolinate;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- fluoro-2-methylisonicotinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methoxyisonicotinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-2-oxo-1,2-dihydropyridine-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-2-oxo-1,2- dihydropyridine-4-carboxamide;

N-((R)-5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-((R)- 2-hydroxypropyl)-2-oxo-1,2- dihydropyridine-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methyloxazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-4-fluoro-2,3-dihydro-1H-inden-1- yl)-1-methyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,3- dimethyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylisoxazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methylisoxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methylisoxazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,3- dimethyl-1H-pyrazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,2- dimethyl-1H-imidazole-5- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylisoxazole-3-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,5- dimethyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,5- dimethyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-5-methyl-1H-pyrazole- 4-carboxamide;

(R)-1-(2-ethoxyethyl)-N-(5-(5-ethyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-5-methyl-1H-pyrazole- 4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-5-methyl-1H-pyrazole- 4-carboxamide;

N-((R)-5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-((R)-2-hydroxypropyl)-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- (hydroxymethyl)isonicotinamide;

(R)-2-(difluoromethyl)-N-(5-(5-ethyl- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)isonicotinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-imidazole-2-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,5- dimethyl-1H-pyrazole-3-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isoxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isoxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isoxazole-3-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isoxazole-3-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-4-carboxamide;

(R)-N-(7-chloro-5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-6-oxo-1,6-dihydropyridine-3- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methylthiazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-pyrazole-3-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)oxazole-2-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6- methylpicolinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- methylthiazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-3-methyl-1H-pyrazole- 4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-3-methyl-1H-pyrazole- 4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(3- methoxypropyl)-5-methyl-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(3- methoxypropyl)-5-methyl-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(3-methoxypropyl)-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-cyclopropyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(3-hydroxypropyl)-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-1H-pyrazole-3- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6-oxo- 1,6-dihydropyridine-3-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6-oxo- 1,6-dihydropyridine-3-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-6-oxo-1,6- dihydropyridine-3-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- methoxyethyl)-6-oxo-1,6- dihydropyridine-3-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-1H-pyrazole-5- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(2- hydroxyethyl)-1H-pyrazole-3- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-7-hydroxy-2,3-dihydro-1H-inden- 1-yl)-1-methyl-1H-pyrazole-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2-(2- hydroxypropan-2-yl)isonicotinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(3- hydroxypropyl)-5-methyl-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1-(3- hydroxypropyl)-3-methyl-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- (hydroxymethyl)-1-methyl-1H- imidazole-5-carboxamide;

(R)-2-(5-((5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)carbamoyl)-2-oxopyridin-1(2H)- yl)acetic acid;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,2,5- oxadiazole-3-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1- methyl-1H-1,2,3-triazole-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methyl-1,3,4-oxadiazole-2- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methyl-1,3,4-oxadiazole-2- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methyl-1,3,4-thiadiazole-2- carboxamide;

(R)-3-chloro-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isoxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-1,5- dimethyl-1H-1,2,3-triazole-4- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methyloxazole-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)picolinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)nicotinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6- methylnicotinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylnicotinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-4- methylnicotinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methylisonicotinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)pyrimidine-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6- methylpyrimidine-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)pyridazine-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-4- methyl-1,2,5-oxadiazole-3- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- hydroxyisoxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methoxyisoxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methyloxazole-2-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methylpyridazine-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- hydroxyoxazole-5-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-4- (trifluoromethyl)oxazole-5- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylthiazole-2-carboxamide;

(R)-1-ethyl-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-6-oxo-1,6-dihydropyridine-3- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylpicolinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-5- methylpyrimidine-4-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-6-oxo-1,6- dihydropyridine-3-carboxamide;

(R)-N-(5-(5-cyclobutyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-methyl-6-oxo-1,6- dihydropyridine-3-carboxamide;

(R)-1-methyl-N-(5-(5-(methyl-d3)- 1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)-6-oxo-1,6- dihydropyridine-3-carboxamide;

(R)-2-chloro-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)isonicotinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-6- methylpyridazine-4-carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-4- (hydroxymethyl)picolinamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-2- vinylisonicotinamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-6-oxo-1,6- dihydropyridine-3-carboxamide;

(R)-2-ethyl-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- yl)isonicotinamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2- (hydroxymethyl)isonicotinamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2- (hydroxymethyl)isonicotinamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-(hydroxymethyl)picolinamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-(hydroxymethyl)picolinamide;

(R)-4-(hydroxymethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)picolinamide;

(R)-4-(hydroxymethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)picolinamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-hydroxyisoxazole-5- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-5-methyl-1H- pyrazole-4-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylthiazole-5-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-4- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,2-dimethyl-1H-imidazole-5- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-5- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methoxyisoxazole-5- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methyloxazole-2-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-(trifluoromethyl)oxazole-5- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-6-methylpyrimidine-4- carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methoxyisonicotinamide;

(R)-2-(difluoromethyl)-N-(5-(5- (difluoromethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1-(2-hydroxyethyl)-3-methyl- 1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-(difluoromethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-6-methylpyridazine-4- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-5- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-3-methylisoxazole-4- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methylisoxazole-3- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-1,2-dimethyl-1H-imidazole-5- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-4-methyl-1,2,5-oxadiazole-3- carboxamide;

(R)-3-methoxy-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3-yl)- 2,3-dihydro-1H-inden-1- yl)isoxazole- 5-carboxamide;

(R)-1-(2-hydroxyethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl-5- methyl-1H-pyrazole-4-carboxamide;

(R)-1-(2-hydroxyethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1-yl)-3- methyl-1H-pyrazole-4-carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-2-methylthiazole-5-carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methyl-1,3,4-oxadiazole-2- carboxamide;

(R)-N-(5-(5-(methoxymethyl)-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H-inden- 1-yl)-5-methyl-1,3,4-oxadiazole-2- carboxamide;

(R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3- yl)-6-fluoro-2,3-dihydro-1H-inden-1- yl)-1-methyl-1H-pyrazole-4- carboxamide;

(R)-1,2-dimethyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro- 1H-inden-1-yl)-1H-imidazole-5- carboxamide;

(R)-5-methyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro- 1H-inden-1-yl)-1,3,4-oxadiazole- 2-carboxamide;

(R)-1-(2-hydroxyethyl)-5-methyl- N-(5-(3-methyl-1,2,4-oxadiazol- 5-yl)-2,3-dihydro-1H-inden-1-yl)- 1H-pyrazole-4-carboxamide;

(R)-6-methyl-N-(5-(3-methyl- 1,2,4-oxadiazol-5-yl)-2,3-dihydro- 1H-inden-1-yl)pyridazine-4- carboxamide;

(R)-2-(difluoromethyl)-N-(5-(3- methyl-1,2,4-oxadiazol-5-yl)-2,3- dihydro-1H-inden-1- yl)isonicotinamide;

(R)-4-acetyl-N-(5-(5-ethyl-1,2,4- oxadiazol-3-yl)-2,3-dihydro-1H- inden-1-yl)picolinamide;

N-((R)-5-(5-ethyl-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1-yl)- 4-(1-hydroxyethyl)picolinamide;

(R)-2-(hydroxymethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol-3- yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-2-(difluoromethyl)-N-(5-(5- methyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1- yl)isonicotinamide;

(R)-2-(difluoromethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)isonicotinamide;

(R)-4-(difluoromethyl)-N-(5-(5- methyl-1,2,4-oxadiazol-3-yl)-2,3- dihydro-1H-inden-1- yl)picolinamide; and

(R)-4-(difluoromethyl)-N-(5-(5- (methoxymethyl)-1,2,4-oxadiazol- 3-yl)-2,3-dihydro-1H-inden-1- yl)picolinamide.

30. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

31. A method of treating heart disease in a subject in need thereof, comprising administering to the subject a compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the heart disease is hypertrophic cardiomyopathy (HCM) or heart failure with preserved ejection fraction (HFpEF).

32. The method of claim 31 , wherein the heart disease is hypertrophic cardiomyopathy (HCM).

33. The method of claim 32 , wherein the HCM is obstructive or nonobstructive or is associated with a sarcomeric and/or non-sarcomeric mutation.

34. The method of claim 31 , wherein the heart disease is heart failure with preserved ejection fraction (HFpEF).

35. A method of inhibiting the cardiac sarcomere, comprising contacting the cardiac sarcomere with a compound of claim 1 , or a pharmaceutically acceptable salt thereof.

36. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is

37. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is

38. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is

39. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is

40. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is

41. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is

42. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is

43. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein the compound is

44. The method of claim 31 , wherein the method comprises administering to the subject the compound

or a pharmaceutically acceptable salt thereof.

45. The method of claim 31 , wherein the method comprises administering to the subject the compound

or a pharmaceutically acceptable salt thereof.

46. The method of claim 31 , wherein the method comprises administering to the subject the compound

or a pharmaceutically acceptable salt thereof.

47. The method of claim 31 , wherein the method comprises administering to the subject the compound

or a pharmaceutically acceptable salt thereof.

48. The method of claim 31 , wherein the method comprises administering to the subject the compound

or a pharmaceutically acceptable salt thereof.

49. The method of claim 31 , wherein the method comprises administering to the subject the compound

or a pharmaceutically acceptable salt thereof.

50. The method of claim 31 , wherein the method comprises administering to the subject the compound

or a pharmaceutically acceptable salt thereof.

51. The method of claim 31 , wherein the method comprises administering to the subject the compound

or a pharmaceutically acceptable salt thereof.