Polymer films
Biodegradable, cross-linked polymer films and methods of making the same are described. The polymer films can be used for preventing adhesions following surgery and/or delivering therapeutic agents.
1. A polymer system comprising:
a package; and
a polymer film including at least one acrylate, acrylamide, methacrylate, or methacrylamide monomer and at least one biodegradable crosslinker;
wherein the polymer film has a thickness of less than about 1,500 μm; and
wherein the biodegradable crosslinker is bis-glycidyl amino alcohol, bi-functionalized methacryloyl-Ala-Pro-Gly-Leu-AEE-methacrylate, glycidyl, carbonate, carbamate, TMP gly ester, thioester, jeffamine glycidyl amine,
wherein a, b, c, d, e, and f are each independently 1-20.
2. The polymer system of claim 1 , wherein the polymer film has a shape selected from a circle, square, rectangle, triangle, ellipse, or pentagon.
3. The polymer system of claim 1 , wherein the package is a vial or a pouch.
4. The polymer system of claim 1 , wherein the polymer film is sterilized.
5. The polymer system of claim 1 , wherein the at least one acrylate, acrylamide, methacrylate, or methacrylamide monomer includes an ionizable functional group.
6. The polymer system of claim 5 , wherein the ionizable functional group is acidic or basic.
7. The polymer film of claim 1 , wherein the at least one biodegradable crosslinker includes at least two functional groups.
8. The polymer system of claim 1 , wherein the biodegradable crosslinker includes at least one linkage susceptible to degradation through hydrolysis or enzymatic action.
9. The polymer system of claim 8 , wherein the at least one linkage is an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenase, a peptide cleavable by matrix elastase, a peptide cleavable by matrix cathepsin, or a combination thereof.
10. The polymer system of claim 9 , including a second crosslinker including a second linkage selected from an ester, a thioester, a carbonate, a carbamate, a peptide cleavable by matrix metalloproteinases, a peptide cleavable by matrix collagenases, a peptide cleavable by matrix elastases, and a peptide cleavable by matrix cathepsins.
11. The polymer system of claim 1 , wherein the polymer film is substantially degraded within about 6 months of implantation.
12. The polymer system of claim 1 , wherein the polymer film is substantially degraded within about 1 month of implantation.