Chlorhexidine gluconate compositions, resin systems and articles
Compositions containing chlorhexidine gluconate solubilized in hydrophobic vehicles are described. Resin systems containing such chlorhexidine gluconate compositions, including adhesives and articles incorporating such resin systems, including medical articles such as drapes are also described.
1. A composition comprising chlorhexidine gluconate solubilized in a hydrophobic vehicle having a hydrophilic-lipophilic balance of no greater than 10 as determined using the HLB Method,
wherein the hydrophobic vehicle comprises two proximate hydrogen-bonding groups,
wherein at least one of the hydrogen-bonding groups is a hydrogen donor,
wherein the composition comprises no greater than 2 parts by weight hydrophilic vehicle per 1 part by weight chlorhexidine gluconate, and
wherein the hydrophobic vehicle is a monoacylglycerol.
2. The composition of claim 1 , wherein an alkyl group of the monoacylglycerol is a C8 to C18 alkyl group.
3. The composition of claim 1 , wherein the alkyl group of the monoacylglycerol is a C8 to C18 alkyl group.
4. The composition of claim 1 , wherein the monoacylglycerol is selected from the group consisting of glycerol monocaprylate, glycerol monolaurate, glycerol monoisostearate, glycerol monooleate, and combinations thereof.
5. The composition of claim 1 , wherein the monoacylglycerol is selected from the group consisting of glycerol monocaprylate, glycerol monoisostearate, glycerol monooleate, and combinations thereof.
6. The composition of claim 1 , wherein the composition comprises no greater than 1 part by weight water per 1 part by weight chlorhexidine gluconate.
7. The composition of claim 6 , wherein the composition comprises no greater than 0.1 parts by weight water per 1 part by weight chlorhexidine gluconate.
8. The composition of claim 1 , wherein the monoacylglycerol is a 1-monoacylglyceride.
9. The composition of claim 1 , wherein the composition comprises no greater than 1 part by weight hydrophilic vehicle per 1 part by weight chlorhexidine gluconate.
10. The composition according to claim 1 , further comprising a resin system comprising a polymer.
11. The composition of claim 10 , wherein the resin system comprises a hydrophobic phase, wherein the hydrophobic vehicle plasticizes the hydrophobic phase.
12. The composition of claim 10 , wherein the polymer comprises an acrylate polymer.
13. The composition of claim 10 , wherein the polymer comprises a block copolymer polymer.
14. The composition according to claim 10 , wherein the resin system is a pressure sensitive adhesive.
15. An article comprising a substrate and the composition according to claim 1 bonded to at least a portion of a surface of the substrate.
16. The article according to claim 15 , wherein the article is a medical article.
17. A mixture comprising:
a composition comprising chlorhexidine gluconate solubilized in a hydrophobic vehicle, wherein the hydrophobic vehicle is a monoacylglycerol;
a resin system comprising a hydrophobic phase, wherein the hydrophobic vehicle plasticizes the hydrophobic phase,
wherein the hydrophobic vehicle and the solubilized chlorhexidine gluconate are capable of migrating to a surface of a layer of the resin system providing a replenishable supply of chlorhexidine gluconate to the surface.
18. The mixture of claim 17 , wherein the resin system comprises an alkyl (meth)acrylate monomer, wherein the alkyl group has 4 to 18 carbon atoms.
19. The mixture of claim 17 , wherein the composition comprises no greater than 2 parts by weight hydrophilic vehicle per 1 part by weight chlorhexidine gluconate.
20. The mixture of claim 19 , wherein the composition comprises no greater than 1 part by weight water per 1 part by weight chlorhexidine gluconate.