Compositions and methods for delivering cannabidiol and ketone bodies
Disclosed herein are “ketonnabidiol” compositions including a combination of: (1) cannabidiol (CBD) and/or cannabidiolic acid (CBDA); (2) a ketone body component such as beta-hydroxybutyrate (BHB) and/or acetoacetate; and (3) a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such ketonnabidiol compositions for producing desired physiological effects, such as fat loss, in a mammal. The ketonnabidiol compositions beneficially enhance fat loss through ketosis while also reducing the duration and/or severity of unpleasant “keto flu” symptoms typically associated with ketosis.
1. A composition comprising:
a ketone body component;
a cannabidiol (CBD) component, wherein the CBD component includes a CBD compound having at least one beta-hydroxybutyrate (BHB) or acetoacetate attached to the CBD compound via an ester bond; and
a pharmaceutically or dietetically acceptable carrier.
2. The composition of claim 1 , wherein the ketone body component is selected from the group consisting of BHB salts, BHB esters, beta-hydroxybutyric acid, acetoacetate salts, acetoacetate esters, acetoacetic acid, and combinations thereof.
3. The composition of claim 2 , wherein the ketone body component includes a BHB salt or ester and/or acetoacetate salt or ester.
4. The composition of claim 1 , wherein at least a portion of the ketone body component is provided by the CBD compound having at least one BHB or acetoacetate attached to the CBD compound via an ester bond.
5. The composition of claim 1 , further comprising one or more additional cannabinoid compounds derived from the cannabis plant.
6. The composition of claim 1 , wherein the composition omits THC.
7. The composition of claim 1 , further comprising one or more of 1,3-butanediol, a fatty acid, or an ester of a fatty acid.
8. The composition of claim 7 , wherein the fatty acid or ester thereof is a medium chain fatty acid or ester thereof, or a short chain fatty acid or ester thereof.
9. The composition of claim 1 , wherein the composition is provided in solid or powder form.
10. The composition of claim 1 , wherein the composition is provided in liquid form.
11. The composition of claim 1 , wherein the composition is in a dosage form that provides from about 0.5 grams to about 50 grams of the ketone body component.
12. The composition of claim 1 , wherein the composition is in a dosage form that provides about 3 mg to about 1 gram of the CBD component.
13. The composition of claim 1 , wherein the composition promotes fat loss in a mammal.
14. The composition of claim 1 , wherein the composition provides one or more of homeostasis promotion, appetite suppression, neuroprotection, memory enhancement, an anxiolytic effect, an anti-depressant effect, an anti-inflammation effect, an analgesic effect, an antioxidant effect, blood pressure and/or heart rate modulation, an anti-tumorigenic effect, a longevity promoting effect, and sleep promotion.
15. The composition of claim 1 , wherein the CBD component functions to counteract serotonin reduction associated with administration of the ketone body component.
16. The composition of claim 1 , wherein the composition promotes fat browning in the mammal and increases the effectiveness of lipolysis.
17. The composition of claim 1 , wherein the composition accelerates the production of endogenous ketones.
18. The composition of claim 1 , wherein the ketone body component increases the pharmacokinetic utilization of the CBD component relative to pharmacokinetic utilization of the CBD component in the absence of the ketone body component.
19. The composition of claim 1 , wherein the composition induces sustained ketosis in the mammal with reduced symptoms of hypoglycemia relative to a ketone body composition omitting CBD.
20. The composition of claim 1 , wherein the ketone body component includes BHB and/or acetoacetate, and wherein the BHB and/or acetoacetate enhances effectiveness of the composition at least in part as a result of molecular signaling.
21. The composition of claim 1 , wherein the composition enhances function of the endocannabinoid system in a mammal.
22. A composition comprising:
a cannabidiol (CBD) compound having at least one beta-hydroxybutyrate (BHB) or acetoacetate attached to the CBD compound via an ester bond; and
a pharmaceutically or dietetically acceptable carrier.
23. The composition of claim 22 , further comprising a CBD component separate from the CBD compound having at least one BHB or acetoacetate attached to the CBD compound via an ester bond.
24. The composition of claim 22 , further comprising a ketone body component separate from the CBD compound having at least one BHB or acetoacetate attached to the CBD compound via an ester bond.