Granted Patent B2

US 12,521,378 · App. 17/732,453 · Granted Jan 13, 2026

Inventors: Ryan P. Lowery (Tampa, FL); Jacob Wilson (Tampa, FL)

Assignee: AXCESS GLOBAL SCIENCES, LLC

A61K31/4355A61K9/1075A61K31/00A61K31/19A61K31/4745A61K36/889A61K45/06A61K47/44A61K47/6911A61P3/08A61K9/0053

Abstract

Claims (27)

1 . A method of administering ketone bodies to an individual in order to manage glucose tolerance, improve weight loss, maintain ketosis, or manage ketosis in the individual, the method comprising:

orally administering, to the individual, a pharmaceutically effective amount of beta-hydroxybutyrate, wherein the pharmaceutically effective amount of beta-hydroxybutyrate comprises:

approximately 0.5 g to approximately 15 g of R-beta-hydroxybutyrate; and

less than approximately 10% of L-beta-hydroxybutyrate relative to the amount of total beta-hydroxy-butyrate in the composition.

2 . The method of claim 1 , wherein administering ketone bodies to the individual manages glucose tolerance in the individual.

3 . The method of claim 2 , wherein administering the pharmaceutically effective amount of the beta-hydroxybutyrate increases mental acuity.

4 . The method of claim 1 , wherein administering ketone bodies to the individual maintains or improves weight loss in the individual.

5 . The method of claim 1 , wherein the beta-hydroxybutyrate comprises beta-hydroxybutyrate complexed and/or coupled to at least one of an amino acid or berberine.

6 . The method of claim 1 , wherein the beta-hydroxybutyrate is bound to or complexed with an amino acid selected from the group consisting of leucine, lysine, arginine, histidine, ornithine, creatine, agmatine, citrulline, and combinations thereof.

7 . The method of claim 1 , further comprises administering at least one additional compound selected from the group consisting of:

a short chain fatty acid;

an ester of short chain fatty acid;

a medium chain fatty acid;

an ester of medium chain fatty acid;

a long chain fatty acid; and

an ester of long chain fatty acid.

8 . The method of claim 1 , wherein administering the pharmaceutically effective amount of the beta-hydroxybutyrate comprises administering the beta-hydroxybutyrate with at least one of a flavoring, a vitamin, a mineral, or a binder.

9 . The method of claim 4 , wherein administering the pharmaceutically effective amount of the beta-hydroxybutyrate increases strength.

10 . The method of claim 1 , wherein the R-beta-hydroxybutyrate comprises at least one R-beta-hydroxybutyrate salt.

11 . The method of claim 1 , wherein administering ketone bodies to the individual maintains ketosis in the individual.

12 . The method of claim 11 , wherein the beta-hydroxybutyrate is administered up to 5 times daily.

13 . The method of claim 11 , wherein administering the pharmaceutically effective amount of the beta-hydroxybutyrate increases strength.

14 . The method of claim 11 wherein administering the pharmaceutically effective amount of the beta-hydroxybutyrate increases mental acuity.

15 . The method of claim 11 , wherein administering the pharmaceutically effective amount of the beta-hydroxybutyrate increases at least one of metabolism, fat loss, fat oxidation, motor function, or muscle mass.

16 . The method of claim 1 , further comprising administering a pharmaceutically effective amount of at least one amino acid concurrently with the beta-hydroxybutyrate.

17 . The method of claim 1 , wherein administering ketone bodies to the individual manages ketosis in the individual.

18 . The method of claim 17 , wherein the pharmaceutically effective amount of the beta-hydroxybutyrate comprises less than approximately 2 g of the R-beta-hydroxybutyrate.

Assignments (2)

Continuity (10)

References Cited (400)