Nutritional supplements and therapeutic compositions comprising (r)-3-hydroxybutyrate derivatives
Novel compounds and compositions containing (R)-3-hydroxybutyrate derivatives are disclosed. The compounds and compositions can be used as nutritional supplements to increase physical performance and as therapeutics to ameliorate symptoms of medical conditions, particularly neurological conditions, such as Alzheimer's and similar conditions. Novel methods for making R-3-hydroxybutyrate derivatives also are disclosed. Exemplary methods employ a supercritical solvent, such as supercritical carbon dioxide, and employ a lipase catalyzed esterification or transesterification reaction to produce the (R)-3-hydroxybutyrate derivatives.
1. A compound of Formula 3:
or a pharmaceutically acceptable salt thereof, wherein:
R is (R)-1,3-butanediol;
m is 1;
n is 1; and
x is 2.
2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
3. The compound of claim 1 , wherein: m is 1.
4. A pharmaceutical composition comprising the compound of claim 3 and a pharmaceutically acceptable carrier.
5. The pharmaceutical composition of claim 2 , formulated for oral administration as a nutritional or dietary supplement.
6. The pharmaceutical composition of claim 4 , formulated for oral administration as a nutritional or dietary supplement.