Pharmaceutical compositions comprising DGLA and use of same
The present disclosure provides orally deliverable pharmaceutical compositions comprising DGLA and to methods of using same to treat a variety of conditions and disorders.
1. A method for administering dihomo gamma linolenic acid (DGLA) to a human patient, the method comprising orally administering an effective dose of DGLA to a human patient having a skin disease under fasting conditions that are effective to treat the skin disease.
2. The method of claim 1 , wherein the effective dose of DGLA is at least about 500 mg per day.
3. The method of claim 1 , wherein the skin disease is atopic dermatitis or pruritus.
4. The method of claim 3 , wherein the atopic dermatitis is mild atopic dermatitis, moderate atopic dermatitis, or severe atopic dermatitis.
5. The method of claim 1 , wherein the DGLA is in a form of a triglyceride, an alkyl ester, a free fatty acid, or a salt.
6. The method of claim 1 , wherein the effective dose is administered to the subject daily for a period of at least about 8 weeks.
7. The method of claim 1 wherein the effective dose of DGLA is 500 mg-2000 mg per day.
8. A method of treating a skin disease in a fasting subject, the method comprising orally administering an effective dose of a pharmaceutical comprising at least 95% DGLA, by weight of total fatty acids, to a fasting subject having a skin disease.
9. The method of claim 8 , wherein the fasting conditions further comprise no food prior to administration of the effective dose of DGLA and no liquids, besides water, prior to administration of the effective dose of DGLA.
10. The method of claim 9 , wherein the effective dose of DGLA is at least 500 mg per day.
11. The method of claim 10 , wherein the skin disease is atopic dermatitis or pruritus, and wherein the atopic dermatitis is mild atopic dermatitis, moderate atopic dermatitis, or severe atopic dermatitis.
12. The method of claim 11 , wherein the DGLA is in a form of a triglyceride, an alkyl ester, a free fatty acid, or a salt.
13. The method of claim 11 , wherein the effective dose is administered to the subject daily for a period of at least about 8 weeks.
14. The method of claim 8 wherein the effective dose of DGLA is 500 mg-2000 mg per day.