IP Library Granted Patent US 11,097,021
Granted Patent B2
US 11,097,021 · App. 16/280,171 · Granted Aug 24, 2021

Polymer based radionuclide containing particulate material

Inventor: Bruce Nathaniel Gray (Claremont, AU)
Assignee: Sirtex Medical Limited
A61K51/1251A61K51/06A61K51/1255
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Quick Facts
Patent No.
US 11,097,021
App. No.
16/280,171
Granted
Aug 24, 2021
Kind
B2
Abstract

The invention relates to a particulate material having a diameter in the range of from 5 to 200 microns comprising polymeric matrix stably incorporated radionuclide, processes for its production and method of radiation therapy utilising the particulate material.

Claims (9)

1. A process for the production of a particulate material having a diameter in the range of from 5 to 200 microns comprising a polymeric matrix and a radionuclide, the process comprising the steps of:

solubilizing the radionuclide in a solubilisation solution,

preparing a slurry of the polymeric matrix in water,

transferring the slurry to a reaction vessel and adding the solubilized radionuclide to the reaction vessel,

mixing the slurry of the polymeric matrix and the radionuclide until homogenous, and

precipitating the radionuclide as a phosphate salt by the addition of tri-sodium phosphate solution, wherein the radionuclide is stably incorporated such that there is less than 0.4% unbound or unprecipitated radionuclide, and wherein the resulting particulate material has an activity of 3000 MBq.

2. The process according to claim 1 wherein the radionuclide is stably incorporated by precipitation into the polymeric matrix.

3. The process according to claim 1 wherein the radionuclide is yttrium-90.

4. The process according to claim 1 wherein the polymeric matrix is an ion exchange resin.

Assignments (2)
RELEASE OF SECURITY INTEREST Recorded Jun 27, 2024
From: CHINA CITIC BANK INTERNATIONAL LIMITED
To: GRAND PHARMA SPHERE (AUSTRALIA BIDCO) PTY LTD; SIRTEX MEDICAL PTY LTD; SIRTEX MEDICAL PRODUCTS PTY LTD; SIRTEX GLOBAL PTY LTD; SIRTEX TECHNOLOGY PTY LTD
Reel/Frame 067944/0310 →
SECURITY INTEREST Recorded Jun 16, 2022
From: GRAND PHARMA SPHERE (AUSTRALIA BIDCO) PTY LTD; SIRTEX MEDICAL PTY LTD; SIRTEX MEDICAL PRODUCTS PTY LTD; SIRTEX GLOBAL PTY LTD; SIRTEX TECHNOLOGY PTY LTD
To: CHINA CITIC BANK INTERNATIONAL LIMITED
Reel/Frame 060450/0744 →
Continuity (6)
Continuation 13968921 · Aug 16, 2013
Continuation 12712843 · Feb 25, 2010
Continuation 11743530 · May 2, 2007
Continuation 10173496 · Jun 17, 2002
Continuation PCTAU0101370 · Oct 25, 2001
Related Publication 20190175768A1 · Jun 13, 2019