2′-substituted-N6-substituted purine nucleotides for RNA virus treatment
The use of described compounds or pharmaceutically acceptable salts or compositions thereof for the treatment of a host infected with an RNA virus other than HCV, or other disorder more fully described herein.
1. A method to treat a host infected with Dengue Fever comprising administering an effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof to treat the host in need thereof;
wherein:
R 7 is C 1-6 alkyl, C 3-7 cycloalkyl, or aryl;
R 8 is hydrogen or C 1-6 alkyl;
R 9a and R 9b are independently selected from hydrogen, C 1-6 alkyl, cycloalkyl, aryl and aryl(C 1-3 alkyl)-;
R 10 is hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, or C 3-7 cycloalkyl; and
R 11 is C 1-6 alkyl, cycloalkyl, C 2-6 alkynyl, C 2-6 alkenyl, or acyl.
2. The method of claim 1 , wherein R 7 is aryl.
3. The method of claim 1 , wherein R 8 is hydrogen.
4. The method of claim 1 , wherein R 10 is C 1 -C 6 alkyl.
5. The method of claim 1 ,
wherein
R 7 is phenyl;
R 8 is hydrogen;
R 9a and R 9b are independently selected from methyl and hydrogen; and
R 10 is isopropyl.
6. The method of claim 5 , wherein:
R 7 is phenyl;
R 8 is hydrogen;
R 9a is methyl;
R 9b is hydrogen;
R 10 is isopropyl; and
the phosphoramidate is in the L-configuration.
7. The method of claim 1 , wherein the host is a human.
8. The method of claim 7 , wherein the Dengue fever is Dengue fever 2.
9. The method of claim 7 , wherein the Dengue fever is Dengue fever 3.
10. A method to treat a human infected with Dengue Fever comprising administering an effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof to treat the human in need thereof.
11. The method of claim 10 , comprising administering a compound of the formula
or a pharmaceutically acceptable salt thereof.
12. The method of claim 10 , comprising administering a compound of the formula
or a pharmaceutically acceptable salt thereof.
13. The method of claim 10 , wherein the Dengue fever is Dengue fever 2.
14. The method of claim 10 , wherein the Dengue fever is Dengue fever 3.
15. The method of claim 11 , wherein the Dengue fever is Dengue fever 2.
16. The method of claim 11 , wherein the Dengue fever is Dengue fever 3.
17. A method to treat a human infected with Dengue Fever comprising administering an effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof to treat the human in need thereof.
18. The method of claim 17 , comprising administering a compound of the formula
or a pharmaceutically acceptable salt thereof.
19. The method of claim 17 , comprising administering a compound of the formula
or a pharmaceutically acceptable salt thereof.
20. The method of claim 17 , wherein the Dengue fever is Dengue fever 2.
21. The method of claim 17 , wherein the Dengue fever is Dengue fever 3.
22. The method of claim 18 , wherein the Dengue fever is Dengue fever 2.
23. The method of claim 18 , wherein the Dengue fever is Dengue fever 3.