Methods for treating hair loss disorders
The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
1. A method of treating a hair loss disorder in a subject in need thereof, the method consisting of: administering to the subject an effective amount of a small molecule janus kinase (JAK) 1 and/or JAK2 inhibitor, wherein the JAK1 and/or JAK2 inhibitor comprises one or more isotopes.
2. The method of claim 1 , wherein the JAK1 and/or JAK2 inhibitor is selected from ruxolitinib (INCB018424), filgotinib (GLPG0634), Tyrphostin B42 (AG490), momelotinib (CYT387), pacritinib (SB1518), baricitinib (LY3009104), AZD1480, fedratinib (TG101348), BMS-911543, and lestaurtinib (CEP-701), a pharmaceutically acceptable salt thereof, or a combination thereof.
3. The method of claim 1 , wherein the hair loss disorder is androgenetic alopecia, telogen effluvium, tinea capitis, patchy alopecia areata, alopecia totalis, hypotrichosis, hereditary hypotrichosis simplex, alopecia universalis, or a combination thereof.
4. The method of claim 1 , wherein the hair loss disorder is alopecia areata.
5. The method of claim 1 , wherein the hair loss disorder is patchy alopecia areata.
6. The method of claim 1 , wherein the hair loss disorder is alopecia totalis.
7. The method of claim 1 , wherein the hair loss disorder is alopecia universalis.
8. The method of claim 1 , wherein the hair loss disorder is androgenetic alopecia.
9. The method of claim 1 , wherein the JAK1 and/or JAK2 inhibitor is administered topically.
10. The method of claim 1 , wherein the JAK1 and/or JAK2 inhibitor is administered orally.
11. The method of claim 1 , wherein the JAK1 and/or JAK2 inhibitor is administered via a route selected from the group consisting of intra-muscular injection, intra-peritoneal injection, an infusion, intravenous, intradermal, subcutaneous, oral, inhalation, transdermal, topical, transmucosal, nasal, rectal, and a combination thereof.
12. The method of claim 1 , wherein the JAK1 and/or JAK2 inhibitor is administered in a pharmaceutical composition selected from the group consisting of a solution, suspension, capsule, tablet, pill, troche, nasal spray, suppository, ointment, salve, gel, or cream.
13. The method of claim 1 , wherein administering to the human occurs twice daily, daily, weekly, twice weekly, monthly, twice monthly, yearly, 1 time per week, 2 times per week, 3 times per week, 4 times per week, 5 times per week, 6 times per week, 7 times per week, 8 times per week, 9 times per week, 10 times per week, 11 times per week, 12 times per week, 13 times per week, or 14 times per week.
14. The method of claim 1 , wherein treating a hair loss disorder is by inducing hair growth.
15. The method of claim 1 , wherein the compound is suitable for nuclear magnetic resonance (NMR).
16. The method of claim 1 , wherein the one or more isotopes is a radioisotope.
17. The method of claim 1 , wherein the one or more isotopes are isotopes of carbon or hydrogen.
18. The method of claim 17 , wherein the hair loss disorder is patchy alopecia areata.
19. The method of claim 17 , wherein the hair loss disorder is alopecia totalis.
20. The method of claim 17 , wherein the hair loss disorder is alopecia universalis.
21. The method of claim 17 , wherein the JAK1 and/or JAK2 inhibitor is administered topically.
22. The method of claim 17 , wherein JAK1 and/or JAK2 inhibitor is administered orally.
23. The method of claim 17 , wherein the JAK1 and/or JAK2 inhibitor is suitable for NMR.
24. The method of claim 1 , wherein the effective amount of the JAK1 and/or JAK2 inhibitor administered to the subject is selected from about 0.0001 μg/kg body weight, about 0.00025 μg/kg body weight, about 0.0005 μg/kg body weight, about 0.00075 μg/kg body weight, about 0.001 μg/kg body weight, about 0.0025 μg/kg body weight, about 0.005 μg/kg body weight, about 0.0075 μg/kg body weight, about 0.01 μg/kg body weight, about 0.025 μg/kg body weight, about 0.05 μg/kg body weight, about 0.075 μg/kg body weight, about 0.1 μg/kg body weight, about 0.25 μg/kg body weight, about 0.5 μg/kg body weight, about 0.75 μg/kg body weight, about 1 μg/kg body weight, about 5 μg/kg body weight, about 10 μg/kg body weight, about 25 μg/kg body weight, about 50 μg/kg body weight, about 75 μg/kg body weight, about 100 μg/kg body weight, about 150 μg/kg body weight, about 200 μg/kg body weight, about 250 μg/kg body weight, about 300 μg/kg body weight, about 350 μg/kg body weight, about 400 μg/kg body weight, about 450 μg/kg body weight, about 500 μg/kg body weight, about 550 μg/kg body weight, about 600 μg/kg body weight, about 650 μg/kg body weight, about 700 μg/kg body weight, about 750 μg/kg body weight, about 800 μg/kg body weight, about 850 μg/kg body weight, about 900 μg/kg body weight, about 950 μg/kg body weight, about 1000 μg/kg body weight, about 2000 μg/kg body weight, about 3000 μg/kg body weight, about 4000 μg/kg body weight, about 5000 μg/kg body weight, about 6000 μg/kg body weight, about 7000 μg/kg body weight, about 8000 μg/kg body weight, about 95000 μg/kg body weight, or about 10,000 μg/kg body weight, about 1 mg/kg body weight, about 1.5 mg/kg body weight, about 2 mg/kg body weight, about 2.5 mg/kg body weight, about 3 mg/kg body weight, about 3.5 mg/kg body weight, about 4 mg/kg body weight, about 4.5 mg/kg body weight, about 5 mg/kg body weight, about 5.5 mg/kg body weight, about 6 mg/kg body weight, about 6.5 mg/kg body weight, about 7 mg/kg body weight, about 7.5 mg/kg body weight, about 8 mg/kg body weight, about 9.5 mg/kg body weight, about 10 mg/kg body weight, about 10.5 mg/kg body weight, about 11.0 mg/kg body weight, about 11.5 mg/kg body weight, about 12 mg/kg body weight, about 12.5 mg/kg body weight, about 13 mg/kg body weight, about 13.5 mg/kg body weight, about 14 mg/kg body weight, about 14.5 mg/kg body weight, about 15 mg/kg body weight, about 15.5 mg/kg body weight, about 16 mg/kg body weight, about 16.5 mg/kg body weight, about 17 mg/kg body weight, about 17.5 mg/kg body weight, about 18 mg/kg body weight, about 19.5 mg/kg body weight, about 20 mg/kg body weight, about 21.5 mg/kg body weight, about 22 mg/kg body weight, about 22.5 mg/kg body weight, about 23 mg/kg body weight, about 23.5 mg/kg body weight, about 24 mg/kg body weight, about 24.5 mg/kg body weight, about 25 mg/kg body weight, about 25.5 mg/kg body weight, about 26 mg/kg body weight, about 26.5 mg/kg body weight, about 27 mg/kg body weight, about 27.5 mg/kg body weight, about 28 mg/kg body weight, about 29.5 mg/kg body weight, or about 30 mg/kg body weight.
25. The method of claim 1 , wherein administering to the subject occurs for at least 1 week.