Methods of use of cyclopamine analogs
The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
1. A method for treating basal cell carcinoma or Gorlin's syndrome in a subject, the method comprising administering to the subject a composition comprising a compound having the structure:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.
2. The method of claim 1 , wherein the compound is in the form of a pharmaceutically acceptable salt.
3. The method of claim 2 , wherein the salt is an acid salt.
4. The method of claim 3 , wherein the salt is an inorganic acid salt.
5. The method of claim 3 , wherein the salt is a hydrochloric acid salt.
6. The method of claim 1 , wherein the compound is in the form of an iso-propanol solvate of a hydrochloric acid salt.
7. The method of claim 1 , wherein the composition is a liquid composition.
8. The method of claim 1 , wherein the composition is in the form of a cream, ointment, or spray.
9. The method of claim 1 , wherein the composition is administered topically.
10. The method of claim 1 , wherein said administering is carried out in combination with an additional cancer treatment.
11. The method of claim 10 , wherein said additional cancer treatment comprises radiation, surgery, or administration of a second chemotherapeutic agent.