Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
1. A foam able composition formulated for administration to the skin comprising a carrier composition comprising:
a) a short chain alcohol comprising ethanol present at a concentration of at least 55% by weight of the carrier;
b) about 2% to about 50% by weight of the carrier of a protic polar solvent comprising propylene glycol;
c) a polymeric agent comprising a cellulose ether, wherein the cellulose ether is a hydroxypropyl cellulose present at a concentration of about 0.5% to about 1% by weight of the carrier;
d) a modulating agent comprising an antioxidizing agent present at a concentration of about 0.1% to about 10% by weight of the carrier;
e) a metal;
f) an essential oil; and
g) tetracycline in a therapeutically effective amount of about 1% to about 5% by weight of the carrier,
wherein the composition is surfactant free, nonaqueous, and tree or essentially free of fatty alcohol.
2. The foamable composition of claim 1 , wherein the protic polar solvent is at a concentration of about 12% to about 30% by weight of the carrier.
3. The foamable composition of claim 1 , further comprising a liquefied or compressed gas propellant present at a concentration of about 3% to about 25% by weight of the foamable composition.
4. A foamable composition formulated for administration to the skin comprising a carrier composition comprising:
a) a short chain alcohol comprising ethanol;
b) about 12% to about 30% by weight of the carrier of a protic polar solvent comprising propylene glycol;
c) a polymeric agent comprising a cellulose ether;
d) a modulating agent comprising an antioxidizing agent;
e) a metal;
f) an essential oil; and
g) tetracycline in a therapeutically effective amount of about 1% to about 5% by weight of the carrier,
wherein the composition is surfactant free, nonaqueous, and free or essentially free of fatty alcohol.
5. The foamable composition of claim 4 , wherein the short chain alcohol is present at a concentration of at least 55% by weight of the carrier.
6. The foamable composition of claim 4 , wherein the cellulose ether is a hydroxypropyl cellulose.
7. The foamable composition of claim 4 , wherein the cellulose ether is present in a concentration of about 0.5% to about 1% by weight of the carrier.
8. The foamable composition of claim 4 , wherein the modulating agent is present at a concentration of about 0.1% to about 10% by weight of the carrier.
9. The foamable composition of claim 4 , further comprising a liquefied or compressed propellant at a concentration of about 3% to about 25% by weight of the foamable composition.