Food and beverage compositions infused with lipophilic active agents and methods of use thereof
Aspects described herein relate to food and beverage compositions infused with lipophilic active agents and methods of use for the treatment of a variety of disorders. More particularly, aspects described herein relate to food and beverage compositions infused with lipophilic active agents such as cannabinoids, nicotine, nonsteroidal anti-inflammatories (NSAIDs), and vitamins, that provide enhanced bioavailability of the lipophilic active agents in a subject, and that mask unpleasant tastes of lipophilic active agents.
1. Lipophilic active agent infused tea leaves, coffee beans, or cocoa powder comprising:
(a) a therapeutically effective amount of the lipophilic active agent;
(b) a bioavailability enhancing agent comprising an edible oil comprising long chain fatty acids, wherein the bioavailability of the lipophilic active agent in a subject is at least 1.5 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent; and
(c) tea leaves, coffee beans, or cocoa powder;
wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder are obtainable by the steps of:
(i) contacting the tea leaves, coffee beans, or cocoa powder with an oil comprising the lipophilic active agent and the bioavailability enhancing agent; and
(ii) dehydrating the tea leaves, coffee beans, or cocoa powder, thereby producing the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder; and wherein the lipophilic active agent is selected from the group consisting of a cannabinoid, nicotine, a nonsteroidal anti-inflammatory (NSAID), and a vitamin.
2. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 1 , wherein the bioavailability of the lipophilic active agent in a subject is at least 3 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent.
3. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 1 , wherein the bioavailability of the lipophilic active agent in a subject is at least 4.5 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent.
4. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 1 , wherein the bioavailability enhancing agent is free of omega-6 fatty acids.
5. The lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 1 , further wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder are lyophilized.
6. A lipophilic active agent infused beverage product obtainable by the steps of:
(a) contacting tea leaves, coffee beans, or cocoa powder with an oil comprising a lipophilic active agent and a bioavailability enhancing agent;
(b) dehydrating the tea leaves, coffee beans, or cocoa powder, thereby producing lipophilic active agent infused tea leaves, coffee beans, or cocoa powder; and
(c) steeping the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder in a liquid, thereby producing the lipophilic active agent infused beverage product;
wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder comprise:
(i) a therapeutically effective amount of a lipophilic active agent;
(ii) a bioavailability enhancing agent comprising an edible oil comprising long chain fatty acids, wherein the bioavailability of the lipophilic active agent in a subject is at least 1.5 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent; and
(iii) tea leaves, coffee beans, or cocoa powder; and
wherein the lipophilic active agent is selected from the group consisting of a cannabinoid, nicotine, a nonsteroidal anti-inflammatory (NSAID), and a vitamin.
7. The lipophilic active agent infused beverage product of claim 6 , wherein the bioavailability of the lipophilic active agent in a subject is at least 3 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent.
8. The lipophilic active agent infused beverage product of claim 6 , wherein the bioavailability of the lipophilic active agent in a subject is at least 4.5 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent.
9. The lipophilic active agent infused beverage product of claim 6 , wherein the bioavailability enhancing agent is free of omega-6 fatty acids.
10. The lipophilic active agent infused beverage product of claim 6 , further wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder are lyophilized.
11. A process for making lipophilic active agent infused tea leaves, coffee beans, or cocoa powder comprising the steps of:
contacting tea leaves, coffee beans, or cocoa powder with an oil comprising a lipophilic active agent and a bioavailability enhancing agent; and
(ii) dehydrating the tea leaves, coffee beans, or cocoa powder;
thereby producing the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder; wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder comprise a therapeutically effective amount of the lipophilic active agent, and further wherein the bioavailability enhancing agent comprises an edible oil comprising long chain fatty acids, wherein the bioavailability of the lipophilic active agent in a subject is at least 1.5 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent; and wherein the lipophilic active agent is selected from the group consisting of a cannabinoid, nicotine, a nonsteroidal anti-inflammatory (NSAID), and a vitamin.
12. The process for making the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 11 , wherein the bioavailability of the lipophilic active agent in a subject is at least 3 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent.
13. The process for making the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 11 , wherein the bioavailability of the lipophilic active agent in a subject is at least 4.5 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent.
14. The process for making the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 11 , wherein the bioavailability enhancing agent is free of omega-6 fatty acids.
15. The process for making the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder of claim 11 , further wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder are lyophilized.
16. A process for making a lipophilic active agent infused beverage product comprising the steps of:
(i) contacting tea leaves, coffee beans, or cocoa powder with an oil comprising a lipophilic active agent and a bioavailability enhancing agent;
(ii) dehydrating the tea leaves, coffee beans, or cocoa powder, thereby producing lipophilic active agent infused tea leaves, coffee beans, or cocoa powder; and
(iii) steeping the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder in a liquid, thereby producing the lipophilic active agent infused beverage product;
wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder comprise a therapeutically effective amount of the lipophilic active agent, and further wherein the bioavailability enhancing agent comprises an edible oil comprising long chain fatty acids, wherein the bioavailability of the lipophilic active agent in a subject is at least 1.5 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent; and wherein the lipophilic active agent is selected from the group consisting of a cannabinoid, nicotine, a nonsteroidal anti-inflammatory (NSAID), and a vitamin.
17. The process for making the lipophilic active agent infused beverage product of claim 16 , wherein the bioavailability of the lipophilic active agent in a subject is at least 3 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent.
18. The process for making the lipophilic active agent infused beverage product of claim 16 , wherein the bioavailability of the lipophilic active agent in a subject is at least 4.5 times greater than the bioavailability of the lipophilic active agent in the subject in the absence of the bioavailability enhancing agent.
19. The process for making the lipophilic active agent infused beverage product of claim 16 , wherein the bioavailability enhancing agent is free of omega-6 fatty acids.
20. The process for making the lipophilic active agent infused beverage product of claim 16 , further wherein the lipophilic active agent infused tea leaves, coffee beans, or cocoa powder are lyophilized.