Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors
The present invention relates to novel substituted pyrazoloazepin-4-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.
1. A compound of general formula (I)
wherein
R 1 and R 4 are independently selected from the group consisting of hydrogen and (C 1 -C 4 )alkyl;
R 2 and R 3 are independently selected from the group consisting of hydrogen and (C 1 -C 4 )alkyl; or R 2 and R 3 together with the carbon atom to which they are attached form a cyclopropyl, cyclobutyl, cyclopentyl, oxetanyl, tetrahydrofuranyl, or tetrahydropyranyl ring;
n=0, 1 or 2;
Q is selected from the group consisting of —O—C(O)—R 5 ;
R 5 is selected from the group consisting of (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, aryl; wherein said aryl is optionally substituted with one or more substituents independently selected from R 6 , or wherein said aryl is optionally benzodioxole; and wherein said (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl are optionally substituted with one or more substituents independently selected from R 7 ;
R 6 consists of halogen, cyano, hydroxyl, (C 1 -C 4 )alkyl, halo(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyloxy, —S(O) 2 R x , —S(O) 2 NR a R b , —C(O)R x , —C(O)NR a R b and —OR x ;
R 7 consists of halogen, hydroxyl, cyano, (C 1 -C 4 )alkoxy, —C(O)NR a R b , —C(O)OR a , —S(O) 2 R x , —S(O) 2 NR a R b , —OR x , and —SR x ;
R x consists of (C 1 -C 6 )alkyl and (C 3 -C 6 )cycloalkyl;
R a and R b are independently selected from the group consisting of hydrogen, (C 1 -C 4 )alkyl, phenyl-(C 1 -C 4 )alkyl, or
R a and R b together with the nitrogen to which they are attached form a 4-6 membered heterocycloalkyl, wherein said heterocycloalkyl is optionally substituted with one or more (C 1 -C 4 )alkyl, —C(O)R x ;
or a pharmaceutically acceptable salt, hydrate or solvate thereof.
2. A compound according to claim 1 wherein
R 1 and R 4 are independently selected from the group consisting of hydrogen and (C 1 -C 4 )alkyl;
R 2 and R 3 are independently selected from the group consisting of hydrogen and (C 1 -C 4 )alkyl; or R 2 and R 3 together with the carbon atom to which they are attached form a cyclopropyl or oxetanyl ring;
n=0, 1 or 2;
Q is selected from the group consisting of —O—C(O)—R 5 ;
R 5 is selected from the group consisting of (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, phenyl; wherein said phenyl is optionally substituted with one or more substituents independently selected from R 6 , or wherein R 5 is benzodioxole; and wherein said (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl are optionally substituted with one or more substituents independently selected from R 7 ;
R 6 consists of halogen, cyano, hydroxyl, (C 1 -C 4 )alkyl, halo(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyloxy, —S(O) 2 R x , —S(O) 2 NR a R b , —C(O)R x , —C(O)NR a R b and —OR x ;
R 7 consists of halogen, hydroxyl, cyano, (C 1 -C 4 )alkoxy, —C(O)NR a R b , —C(O)OR a , —S(O) 2 R x , —S(O) 2 NR a R b , —OR x , and —SR x ;
R x consists of (C 1 -C 6 )alkyl and (C 3 -C 6 )cycloalkyl;
R a and R b are independently selected from the group consisting of hydrogen, (C 1 -C 4 )alkyl, phenyl-(C 1 -C 4 )alkyl, or
R a and R b together with the nitrogen to which they are attached form a 4-6 membered heterocycloalkyl, wherein said heterocycloalkyl is optionally substituted with one or more (C 1 -C 4 )alkyl, —C(O)R x ; or
a pharmaceutically acceptable salt, hydrate or solvate thereof.
3. A compound of general formula (I)
wherein
R 1 and R 4 are independently selected from the group consisting of hydrogen and (C 1 -C 4 )alkyl;
R 2 and R 3 are independently selected from the group consisting of hydrogen and (C 1 -C 4 )alkyl; or R 2 and R 3 together with the carbon atom to which they are attached form a cyclopropyl, cyclobutyl, cyclopentyl, oxetanyl, tetrahydrofuranyl, or tetrahydropyranyl ring;
n=0, 1 or 2;
Q is selected from the group consisting of —O—C(O)—R 5 ;
R 5 is selected from the group consisting of (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, halo(C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, aryl; wherein said aryl is optionally substituted with one or more substituents independently selected from R 6 ;
R 6 consists of halogen, cyano, hydroxyl, (C 1 -C 4 )alkyl, halo(C 1 -C 4 )alkyl, (C 1 -C 4 )alkyloxy, —S(O) 2 R x , —S(O) 2 NR a R b and —OR x ;
R x is (C 1 -C 6 )alkyl;
R a and R b are independently selected from the group consisting of hydrogen, (C 1 -C 4 )alkyl, phenyl-(C 1 -C 4 )alkyl, or
R a and R b together with the nitrogen to which they are attached form a 4-6 membered heterocycloalkyl, wherein said heterocycloalkyl is optionally substituted with one or more (C 1 -C 4 )alkyl; or
a pharmaceutically acceptable salt, hydrate or solvate thereof.
4. A compound according to claim 1 wherein all of R 1 , R 2 , R 3 , R 4 are hydrogen, n is 1, and R 5 is phenyl, optionally substituted with one or more substituents independently selected from R 6 .
5. A compound according to claim 1 selected from the group consisting of
3-(3-Ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-methylbenzoate (compound 101);
3-(3-Ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-ethylbenzoate (compound 102);
[(2R)-3-(3-Ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(methylsulfamoyl)benzoate (compound 103);
[(2R)-3-(3-Ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(dimethylsulfamoyl)benzoate (compound 104);
[(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-methylsulfonylbenzoate (compound 105);
or a pharmaceutically acceptable salt, hydrate or solvate thereof.
6. A compound according to claim 1 selected from the group consisting of:
(i) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl acetate
(ii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-methylpropanoate
(iii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-methoxypropanoate
(iv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl cyclopentanecarboxylate
(v) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-hydroxycyclobutanecarboxylate
(vi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-ethyl butanoate
(vii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-isopropoxyacetate
(viii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-methylsulfanylpropanoate
(ix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3,3-difluorocyclobutanecarboxylate
(x) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-methyl benzoate)
(xi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-methyl benzoate
(xii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-hydroxybenzoate
(xiii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-fluorobenzoate
(xiv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-fluorobenzoate
(xv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-fluorobenzoate
(xvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl cis-4-hydroxycyclohexanecarboxylate
(xvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl trans-4-hydroxycyclohexanecarboxylate
(xviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-cyanobenzoate
(xix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-cyanobenzoate
(xx) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-cyanobenzoate
(xxi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3,4-dimethylbenzoate
(xxii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2,4-dimethylbenzoate
(xxiii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-methoxybenzoate
(xxiv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-methoxybenzoate
(xxv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-methoxybenzoate
(xxvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-methylsulfonylpropanoate
(xxvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-fluoro-4-methyl-benzoate
(xxviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-fluoro-4-methyl-benzoate
(xxix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 5-fluoro-2-methyl-benzoate
(xxx) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-fluoro-3-methyl-benzoate
(xxxi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-fluoro-2-methyl-benzoate
(xxxii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-fluoro-5-methyl-benzoate
(xxxiii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-fluoro-2-methyl-benzoate
(xxxiv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-fluoro-6-methyl-benzoate
(xxxv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-chlorobenzoate
(xxxvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-chlorobenzoate)
(xxxvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-chlorobenzoate
(xxxviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3,5-difluorobenzoate
(xxxix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3,4-difluorobenzoate)
(xl) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2,3-difluorobenzoate
(xli) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2,6-difluorobenzoate
(xlii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2,5-difluorobenzoate
(xliii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-methoxycyclohexanecarboxylate
(xliv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4,4-difluorocyclohexanecarboxylate
(xlv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-acetylbenzoate
(xlvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-acetyl benzoate
(xlvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-cyano-3-fluoro-benzoate
(xlviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-cyano-5-fluoro-benzoate
(xlix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-cyano-2-fluoro-benzoate
(l) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-cyano-4-fluoro-benzoate
(li) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 5-cyano-2-fluoro-benzoate
(lii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 1,3-benzodioxole-5-carboxylate
(liii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-methoxy-3-methyl-benzoate
(liv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-methoxy-4-methyl-benzoate
(lv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-methoxy-4-methyl-benzoate
(lvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-ethoxybenzoate
(lvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-fluoro-4-methoxy-benzoate
(lviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-fluoro-5-methoxy-benzoate
(lix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-fluoro-4-methoxy-benzoate
(lx) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-fluoro-3-methoxy-benzoate
(lxi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-fluoro-3-methoxy-benzoate
(lxii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-fluoro-5-methoxy-benzoate
(lxiii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 5-fluoro-2-methoxy-benzoate
(lxiv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-fluoro-6-methoxy-benzoate
(lxv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-fluoro-2-methoxy-benzoate
(lxvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-fluoro-2-methoxy-benzoate
(lxvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-chloro-4-methyl-benzoate
(lxviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-chloro-4-methyl-benzoate
(lxix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-chloro-2-methyl-benzoate
(lxx) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 5-chloro-2-methyl-benzoate
(lxxi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(difluoromethyl)benzoate
(lxxii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-chloro-4-fluoro-benzoate
(lxxiii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-chloro-2-fluoro-benzoate
(lxxiv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-chloro-5-fluoro-benzoate
(lxxv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-chloro-6-fluoro-benzoate
(lxxvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-chloro-3-fluoro-benzoate
(lxxvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-chloro-5-fluoro-benzoate
(lxxviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 5-chloro-2-fluoro-benzoate
(lxxix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-chloro-4-fluoro-benzoate
(lxxx) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-chloro-2-fluoro-benzoate
(lxxxi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-chloro-4-methoxy-benzoate
(lxxxii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-chloro-3-methoxy-benzoate
(lxxxiii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-chloro-5-methoxy-benzoate
(lxxxiv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-chloro-4-methoxy-benzoate
(lxxxv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-chloro-5-methoxy-benzoate
(lxxxvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-chloro-3-methoxy-benzoate
(lxxxvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-chloro-2-methoxy-benzoate
(lxxxviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 5-chloro-2-methoxy-benzoate
(lxxxix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-chloro-2-methoxy-benzoate
(xc) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-(trifluoromethyl)benzoate
(xci) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-(trifluoromethyl)benzoate
(xcii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(trifluoromethyl)benzoate
(xciii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-methylsulfonylbenzoate
(xciv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-methylsulfonylbenzoate
(xcv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-methylsulfonylbenzoate
(xcvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-sulfamoylbenzoate
(xcvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-sulfamoylbenzoate
(xcviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-methyl-3-(trifluoromethyl)benzoate
(xcix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-methyl-3-(trifluoromethyl)benzoate
(c) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-methyl-5-(trifluoromethyl)benzoate
(ci) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-fluoro-2-(trifluoromethyl)benzoate
(cii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-fluoro-6-(trifluoromethyl)benzoate
(ciii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-fluoro-5-(trifluoromethyl)benzoate
(civ) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-fluoro-2-(trifluoromethyl)benzoate
(cv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-fluoro-4-(trifluoromethyl)benzoate
(cvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-fluoro-3-(trifluoromethyl)benzoate
(cvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-fluoro-5-(trifluoromethyl)benzoate
(cviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-fluoro-4-(trifluoromethyl)benzoate
(cix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-ethylsulfonylbenzoate
(cx) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-ethylsulfonylbenzoate
(cxi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-(methylsulfamoyl)benzoate
(cxii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(methylsulfamoyl)benzoate
(cxiii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-methoxy-3-(trifluoromethyl)benzoate
(cxiv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 5-methoxy-2-(trifluoromethyl)benzoate
(cxv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-methoxy-5-(trifluoromethyl)benzoate
(cxvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-chloro-2-(trifluoromethyl)benzoate
(cxvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-chloro-3-(trifluoromethyl)benzoate
(cxviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-chloro-3-(trifluoromethyl)benzoate
(cxix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 5-chloro-2-(trifluoromethyl)benzoate
(cxx) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-chloro-4-(trifluoromethyl)benzoate
(cxxi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-chloro-4-(trifluoromethyl)benzoate
(cxxii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-chloro-5-(trifluoromethyl)benzoate
(cxxiii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2-chloro-5-(trifluoromethyl)benzoate
(cxxiv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-isopropylsulfonylbenzoate
(cxxv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-isopropylsulfonylbenzoate
(cxxvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(dimethylsulfamoyl)benzoate
(cxxvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-cyclopentylsulfonylbenzoate
(cxxviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-pyrrolidin-1-ylsulfonylbenzoate
(cxxix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-pyrrolidin-1-ylsulfonylbenzoate
(cxxx) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 2,4-bis(trifluoromethyl)benzoate
(cxxxi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3,4-bis(trifluoromethyl)benzoate
(cxxxii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-morpholinosulfonylbenzoate
(cxxxiii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-morpholinosulfonylbenzoate
(cxxxiv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(4-acetylpiperazin-1-yl)sulfonylbenzoate
(cxxxv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-carbamoyl benzoate
(cxxxvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(methylcarbamoyl)benzoate
(cxxxvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(ethylcarbamoyl)benzoate
(cxxxviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(dimethylcarbamoyl)benzoate
(cxxxix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(isopropylcarbamoyl)benzoate
(cxl) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(pyrrolidine-1-carbonyl)benzoate
(cxli) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(piperidine-1-carbonyl)benzoate
(cxlii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(morpholine-4-carbonyl)benzoate
(cxliii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(4-methylpiperazine-1-carbonyl)benzoate
(cxliv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 4-(4-acetylpiperazine-1-carbonyl)benzoate;
(cxlv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-carbamoyl benzoate
(cxlvi) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-(methylcarbamoyl)benzoate
(cxlvii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-(ethylcarbamoyl)benzoate
(xlviii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-(dimethylcarbamoyl)benzoate
(cxlix) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-(isopropylcarbamoyl)benzoate
(cl) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-(pyrrolidine-1-carbonyl)benzoate
(cli) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-(piperidine-1-carbonyl)benzoate
(clii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-(morpholine-4-carbonyl)benzoate
(cliii) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-(4-methylpiperazine-1-carbonyl)benzoate
(cliv) 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)propyl 3-(4-acetylpiperazine-1-carbonyl)benzoate
(clv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-methylpropanoate
(clvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] cyclopentanecarboxylate
(clvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-ethylbutanoate
(clviii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] benzoate
(clix) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-methylbenzoate
(clx) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-fluorobenzoate
(clxi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-fluorobenzoate
(clxii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-cyanobenzoate
(clxiii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-cyanobenzoate
(clxiv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3,4-dimethylbenzoate
(clxv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2,4-dimethylbenzoate
(clxvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-methoxybenzoate
(clxvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-fluoro-4-methyl-benzoate
(clxviii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 5-fluoro-2-methyl-benzoate
(clxix) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-fluoro-6-methyl-benzoate
(clxx) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-chlorobenzoate
(clxxi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2,6-difluorobenzoate
(clxxii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2,5-difluorobenzoate
(clxxiii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3,4-difluorobenzoate
(clxxiv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2,3-difluorobenzoate
(clxxv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-acetylbenzoate
(clxxvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-acetylbenzoate
(clxxvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-cyano-5-fluoro-benzoate
(clxxviii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 5-cyano-2-fluoro-benzoate
(clxxix) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-cyano-4-fluoro-benzoate
(clxxx) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-cyano-3-fluoro-benzoate
(clxxxi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-methoxy-3-methyl-benzoate
(clxxxii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-methoxy-4-methyl-benzoate
(clxxxiii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydro-pyran]-1-yl)-2-methyl-propyl] 3-fluoro-4-methoxy-benzoate
(clxxxiv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-fluoro-4-methoxy-benzoate
(clxxxv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-fluoro-3-methoxy-benzoate
(clxxxvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-fluoro-5-methoxy-benzoate
(clxxxvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-fluoro-2-methoxy-benzoate
(clxxxviii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-fluoro-3-methoxy-benzoate
(clxxxix) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-fluoro-6-methoxy-benzoate
(cxc) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-fluoro-2-methoxy-benzoate
(cxci) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-chloro-2-methyl-benzoate
(cxcii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(difluoromethyl)benzoate
(cxciii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-chloro-2-fluoro-benzoate
(cxciv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-chloro-3-fluoro-benzoate
(cxcv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-chloro-5-fluoro-benzoate
(cxcvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-chloro-3-fluoro-benzoate
(cxcvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 5-chloro-2-fluoro-benzoate
(cxcviii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-chloro-6-fluoro-benzoate
(cxcix) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-chloro-4-fluoro-benzoate
(cc) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-chloro-2-fluoro-benzoate
(cci) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-chloro-4-methoxy-benzoate
(ccii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-chloro-3-methoxy-benzoate
(cciii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-chloro-3-methoxy-benzoate
(cciv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-chloro-2-methoxy-benzoate
(ccv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 5-chloro-2-methoxy-benzoate
(ccvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-chloro-2-methoxy-benzoate
(ccvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(trifluoromethyl)benzoate
(ccviii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-methylsulfonylbenzoate
(ccix) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-methylsulfonylbenzoate
(ccx) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-sulfamoylbenzoate
(ccxi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-sulfamoylbenzoate
(ccxii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-methyl-3-(trifluoromethyl)benzoate
(ccxiii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-methyl-5-(trifluoromethyl)benzoate
(ccxiv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-fluoro-4-(trifluoromethyl)benzoate
(ccxv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-fluoro-5-(trifluoromethyl)benzoate
(ccxvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-fluoro-4-(trifluoromethyl)benzoate
(ccxvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-fluoro-2-(trifluoromethyl)benzoate
(ccxviii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 5-fluoro-2-(trifluoromethyl)benzoate
(ccxix) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-fluoro-3-(trifluoromethyl)benzoate
(ccxx) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-fluoro-5-(trifluoromethyl)benzoate
(ccxxi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-ethylsulfonylbenzoate
(ccxxii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-ethylsulfonylbenzoate
(ccxxiii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(methylsulfamoyl)benzoate
(ccxxiv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-methoxy-2-(trifluoromethyl)benzoate
(ccxxv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-methoxy-3-(trifluoromethyl)benzoate
(ccxxvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 5-methoxy-2-(trifluoromethyl)benzoate
(ccxxvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-methoxy-5-(trifluoromethyl)benzoate
(ccxxviii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-methoxy-4-(trifluoromethyl)benzoate
(ccxxix) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-chloro-4-(trifluoromethyl)benzoate
(ccxxx) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-chloro-3-(trifluoromethyl)benzoate
(ccxxxi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-chloro-2-(trifluoromethyl)benzoate
(ccxxxii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-chloro-4-(trifluoromethyl)benzoate
(ccxxxiii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-chloro-3-(trifluoromethyl)benzoate
(ccxxxiv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 5-chloro-2-(trifluoromethyl)benzoate
(ccxxxv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-chloro-5-(trifluoromethyl)benzoate
(ccxxxvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 2-chloro-5-(trifluoromethyl)benzoate
(ccxxxvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-isopropylsulfonylbenzoate
(ccxxxviii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-isopropylsulfonylbenzoate
(ccxxxix) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-cyclopentylsulfonylbenzoate
(ccxl) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-pyrrolidin-1-ylsulfonylbenzoate
(ccxli) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-pyrrolidin-1-ylsulfonylbenzoate
(ccxlii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3,4-bis(trifluoromethyl)benzoate
(ccxliii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-morpholinosulfonylbenzoate
(ccxliv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-morpholinosulfonylbenzoate
(ccxlv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(4-acetylpiperazin-1-yl)sulfonylbenzoate
(ccxlvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(4-acetylpiperazin-1-yl)sulfonylbenzoate
(ccxlvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-carbamoyl benzoate;
(ccxlviii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(methylcarbamoyl)benzoate;
(ccxlix) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(ethylcarbamoyl)benzoate;
(ccl) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(dimethylcarbamoyl)benzoate;
(ccli) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(isopropylcarbamoyl)benzoate;
(cclii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(pyrrolidine-1-carbonyl)benzoate;
(ccliii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(piperidine-1-carbonyl)benzoate;
(ccliv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(piperazine-1-carbonyl)benzoate;
(cclv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(morpholine-4-carbonyl)benzoate;
(cclvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(4-methylpiperazine-1-carbonyl)benzoate;
(cclvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-(4-acetylpiperazine-1-carbonyl)benzoate; [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-carbamoylbenzoate;
(cclix) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(methylcarbamoyl)benzoate;
(cclx) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(ethylcarbamoyl)benzoate;
(cclxi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(dimethylcarbamoyl)benzoate;
(cclxii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(isopropylcarbamoyl)benzoate;
(cclxiii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(pyrrolidine-1-carbonyl)benzoate;
(cclxiv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(piperidine-1-carbonyl)benzoate;
(cclxv) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(piperazine-1-carbonyl)benzoate;
(cclxvi) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(morpholine-4-carbonyl)benzoate;
(cclxvii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(4-methylpiperazine-1-carbonyl)benzoate;
(cclxviii) [(2R)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-(4-acetylpiperazine-1-carbonyl)benzoate
(cclxix) [(2S)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] benzoate;
(cclxx) [(2S)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-methylbenzoate;
(cclxxi) [(2S)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-fluorobenzoate;
(cclxxii) [(2S)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-fluorobenzoate;
(cclxxiii) [(2S)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 3-methoxybenzoate;
(cclxxiv) [(2S)-3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2-methyl-propyl] 4-chlorobenzoate;
(cclxxv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] cyclopentanecarboxylate
(cclxxvi) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 2-ethylbutanoate
(cclxxvii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-methylbenzoate
(cclxxviii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-fluorobenzoate
(cclxxix) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-fluorobenzoate
(cclxxx) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 2-fluorobenzoate
(cclxxxi) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-cyanobenzoate
(cclxxxii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-cyanobenzoate
(cclxxxiii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-methoxybenzoate
(cclxxxiv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-chlorobenzoate
(cclxxxv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-chlorobenzoate
(cclxxxvi) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 2-chlorobenzoate
(cclxxxvii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3,5-difluorobenzoate
(cclxxxviii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3,4-difluorobenzoate
(cclxxxix) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-acetylbenzoate
(ccxc) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-acetylbenzoate
(ccxci) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-cyano-3-fluoro-benzoate
(ccxcii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-cyano-2-fluoro-benzoate
(ccxciii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-ethoxybenzoate
(ccxciv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 2-chloro-6-fluoro-benzoate
(ccxcv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 2-chloro-4-fluoro-benzoate
(ccxcvi) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(trifluoromethyl)benzoate
(ccxcvii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 2-(trifluoromethyl)benzoate
(ccxcviii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(trifluoromethyl)benzoate
(ccxcix) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-methylsulfonylbenzoate
(ccc) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-methylsulfonylbenzoate
(ccci) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 2-methylsulfonylbenzoate
(cccii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-sulfamoylbenzoate
(ccciii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-sulfamoylbenzoate
(ccciv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-fluoro-5-(trifluoromethyl)benzoate
(cccv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-ethylsulfonylbenzoate
(cccvi) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-ethylsulfonylbenzoate
(cccvii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(methylsulfamoyl)benzoate
(cccviii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-chloro-3-(trifluoromethyl)benzoate
(cccix) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 2-chloro-5-(trifluoromethyl)benzoate
(cccx) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-isopropylsulfonylbenzoate
(cccxi) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-isopropylsulfonylbenzoate
(cccxii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(dimethylsulfamoyl)benzoate
(cccxiii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-cyclopentylsulfonylbenzoate
(cccxiv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-pyrrolidin-1-ylsulfonylbenzoate
(cccxv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-pyrrolidin-1-ylsulfonylbenzoate
(cccxvi) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-morpholinosulfonylbenzoate
(cccxvii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-morpholinosulfonylbenzoate
(cccxviii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(4-acetylpiperazin-1-yl)sulfonylbenzoate
(cccxix) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(4-acetylpiperazin-1-yl)sulfonylbenzoate;
(cccxx) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-carbamoylbenzoate;
(cccxxi) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(methylcarbamoyl)benzoate;
(cccxxii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(ethylcarbamoyl)benzoate;
(cccxxiii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(dimethylcarbamoyl)benzoate;
(cccxxiv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(isopropylcarbamoyl)benzoate;
(cccxxv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(pyrrolidine-1-carbonyl)benzoate;
(cccxxvi) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(piperidine-1-carbonyl)benzoate;
(cccxxvii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(piperazine-1-carbonyl)benzoate;
(cccxxviii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(morpholine-4-carbonyl)benzoate;
(cccxxix) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(4-methylpiperazine-1-carbonyl)benzoate;
(cccxxx) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 4-(4-acetylpiperazine-1-carbonyl)benzoate;
(cccxxxi) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-carbamoylbenzoate;
(cccxxxii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(methylcarbamoyl)benzoate;
(cccxxxiii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(ethylcarbamoyl)benzoate;
(cccxxxiv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(dimethylcarbamoyl)benzoate;
(cccxxxv) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(isopropylcarbamoyl)benzoate;
(cccxxxvi) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(pyrrolidine-1-carbonyl)benzoate;
(cccxxxvii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(piperidine-1-carbonyl)benzoate;
(cccxxxviii) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(piperazine-1-carbonyl)benzoate;
(cccxxxix) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(morpholine-4-carbonyl)benzoate;
(cccxl)[3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(4-methylpiperazine-1-carbonyl)benzoate;
(cccxli) [3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)-2,2-dimethyl-propyl] 3-(4-acetylpiperazine-1-carbonyl)benzoate;
(cccxlii) [1-[(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)methyl]cyclopropyl]methyl 4-methyl benzoate;
(cccxliii) [1-[(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)methyl]cyclopropyl]methyl 3-fluorobenzoate;
(cccxliv) [1-[(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)methyl]cyclopropyl]methyl 4-fluorobenzoate;
(cccxlv) [1-[(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)methyl]cyclopropyl]methyl 3-methoxybenzoate;
(cccxlvi) [1-[(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)methyl]cyclopropyl]methyl 4-chlorobenzoate;
(cccxlvii) [3-[(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)methyl]oxetan-3-yl]methyl benzoate;
(cccxlviii) [3-[(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)methyl]oxetan-3-yl]methyl 4-methyl benzoate;
(cccxlix) [3-[(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)methyl]oxetan-3-yl]methyl 3-fluorobenzoate;
(cccl) [3-[(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)methyl]oxetan-3-yl]methyl 4-fluorobenzoate;
(cccli) [3-[(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)methyl]oxetan-3-yl]methyl 3-methoxybenzoate;
(ccclii) [3-[(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)methyl]oxetan-3-yl]methyl 4-chlorobenzoate; 3-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl benzoate
(cccliv) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl benzoate;
(ccciv) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 3-methylbenzoate;
(ccclvi) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-methyl benzoate;
(ccclvii) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-fluorobenzoate;
(ccclviii) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 3-acetylbenzoate;
(ccclix) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-acetylbenzoate;
(cccix) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 3-methylsulfonylbenzoate;
(ccclxi) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-methylsulfonylbenzoate;
(ccclxii) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-ethylsulfonylbenzoate;
(ccclxiii) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 3-(methylsulfamoyl)benzoate;
(ccclxiv) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-(methylsulfamoyl)benzoate;
(ccclxv) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 3-(dimethylsulfamoyl)benzoate;
(ccclxvi) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-(dimethylsulfamoyl)benzoate;
(ccclxvii) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-cyclopentylsulfonylbenzoate;
(ccclxviii) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-pyrrolidin-1-ylsulfonylbenzoate;
(ccclxix) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-morpholinosulfonylbenzoate;
(ccclxx) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-(methylcarbamoyl)benzoate;
(ccclxxi) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-(dimethylcarbamoyl)benzoate;
(ccclxxii) 4-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)butyl 4-(morpholine-4-carbonyl)benzoate;
(ccclxxiii) 2-(3-ethyl-4-oxo-spiro[6,8-dihydro-5H-pyrazolo[4,3-c]azepine-7,4′-tetrahydropyran]-1-yl)ethyl benzoate;
or a pharmaceutically acceptable salt, hydrate or solvate thereof.
7. A pharmaceutical composition comprising a compound according to claim 1 and one or more pharmaceutically acceptable vehicles or excipients and/or one or more pharmaceutically acceptable carriers.
8. The pharmaceutical composition according to claim 7 further comprising one or more other therapeutically active compounds.
9. A method for treatment or alleviation of a disease or a disorder or a condition responsive to PDE4 inhibitory activity, comprising administering to a subject in need thereof a therapeutically effective amount of a compound according to claim 1 .
10. A method of treating or ameliorating one or more dermal diseases or conditions, comprising administering to a person suffering from at least one of said diseases an effective amount of one or more compounds according to according to claim 1 .
11. The method according to claim 10 , wherein the dermal disease or condition is selected from the group consisting of proliferative and inflammatory skin disorders, dermatitis, atopic dermatitis, seborrheic dermatitis, contact dermatitis, psoriasis, cancer, epidermal inflammation, alopecia, alopecia areata, skin atrophy, steroid induced skin atrophy, skin ageing, photo skin ageing, acne, urticaria, pruritis, and eczema.
12. A method of treating or ameliorating dermal diseases or conditions, comprising administering to a person suffering from at least one of said diseases an effective amount of the pharmaceutical composition according to claim 7 .