Granted Patent
B2
US 11,007,181 · App. 16/521,447 · Granted May 18, 2021
Cyclopamine analogs
Inventors:
Brian Austad (Tewksbury, MA); Mark L. Behnke (Somerville, MA); Alfredo C. Castro (Woburn, MA); Michael J. Grogan (Winchester, MA); Somarajannair Janardanannair (Woburn, MA); Andre Lescarbeau (Somerville, MA); Stephane Peluso (Brookline, MA); Andre B. Charette (Longueuil, CA); Martin R. Tremblay (Melrose, MA)
Assignee:
Infinity Pharmaceuticals, Inc.
A61K31/4355A61K9/0014A61K31/17A61K31/196A61K31/198A61K31/454A61K31/4745A61K31/519A61K31/56A61K31/573A61K31/58A61K31/664A61K31/69A61K31/704A61K31/7068A61K31/7076A61K38/21A61K45/06A61N5/10C07D307/94C07D471/04C07D471/10C07D491/04C07D491/048C07D491/10C07D491/107C07J69/00
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Abstract
The invention provides derivatives of cyclopamine having the following formula:
Claims (3)
1. A hydrochloric acid salt of a compound having the structure:
wherein the hydrochloric acid salt is in the form of an iso-propanol solvate.
2. A pharmaceutical composition comprising the hydrochloric acid salt of claim 1 and a pharmaceutically acceptable excipient.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 8, 2020
From: INFINITY PHARMACEUTICALS, INC.
To: ROYALTY SECURITY, LLC
Reel/Frame 051519/0511 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 24, 2019
From: AUSTAD, BRIAN; BEHNKE, MARK L.; CASTRO, ALFREDO C.; GROGAN, MICHAEL J.; JANARDANNAIR, SOMARAJANNAIR; LESCARBEAU, ANDRE; PELUSO, STEPHANE; CHARETTE, ANDRÉ B.; TREMBLAY, MARTIN
To: INFINITY PHARMACEUTICALS, INC.
Reel/Frame 049853/0591 →
Continuity (8)
Provisional Application
60941596
· Jun 1, 2007
Provisional Application
60878018
· Dec 28, 2006
Cited By (1)