Advanced endovascular clip and method of using same

1. A method of treating an aneurysm in the vascular wall in an individual, comprising the step of delivering to the aneurysm an endovascular clip, said clip comprising:

means for anchoring the endovascular clip on a vessel lumen side of an aneurysm, said means comprising at least two anchoring components; and

a distal self-expanding member;

wherein the distal self-expanding member comprises a mesh;

wherein the means for anchoring and distal self-expanding member comprise self-expanding material configured to have an original configuration and a deformed configuration;

wherein said means for anchoring and said distal self-expanding member are configured to extend across opposite sides of a neck of an aneurysm;

a proximal detachable hypotube detachably coupled to the means for anchoring; and

a distal detachable wire detachably coupled to the distal self-expanding member;

wherein the distal detachable wire and proximal detachable hypotube are in a concentric configuration, and

wherein the means for anchoring is disposed proximal to the distal self-expanding member with respect to the hypotube,

wherein the distal detachable wire comprises a manually-adjustable steering joint, and

wherein the means for anchoring and distal self-expanding member are independently detachable and separately maneuverable,

wherein said endovascular clip occludes said aneurysm.

2. The method of claim 1 , wherein the method further comprises incorporation of a swellable gel on the device for further occlusion of the aneurysm.

3. The method of claim 2 , wherein the swellable gel is selected from the group consisting of hydrogel, hydrogel foam, hydrophilic polymers with conjugated collagen, hydrophilic polymers without conjugated collagen, porous hydrated polyvinyl alcohol foam (PAF) gel, and a combination thereof.

4. The method of claim 1 , further comprising incorporation of growth factors or vascular stromal stem cells of the individual delivered to the aneurysm.

5. The method of claim 1 , wherein the distal detachable wire further comprises a locking mechanism.

6. The method of claim 1 , wherein the distal detachable wire further comprises a detaching joint detachably coupling distal and proximal portions of the distal detachable wire.

7. The method of claim 6 , wherein the means for anchoring activates the detaching of the detaching joint.

8. The method of claim 1 , wherein the means for anchoring further comprises a proximal detachment zone.

9. The method of claim 8 , wherein the means for anchoring activates the locking mechanism.

10. The method of claim 8 , wherein the means for anchoring activates the detaching of the proximal detachable hypotube at the proximal detachment zone.

11. The method of claim 1 , wherein the distal self-expanding member original configuration is a conical shape.

12. The method of claim 1 , wherein the distal self-expanding member original configuration is a planar shape.

13. The method of claim 1 , wherein the distal self-expanding member comprises a manually-adjustable shape.

14. The method of claim 1 , wherein the means for anchoring the anchoring components are manually-adjustable.

15. The method of claim 1 , wherein the mesh further comprises a bioactive material configured to promote cell growth.

16. The method of claim 15 , wherein said bioactive material comprises a thrombogenic material selected from the group consisting of collagen, fibrinogen, vitronectin, other plasma proteins, growth factors, peptides of said growth factors having attached RGD (arginine glycine-aspartic acid) residues, phospholipids, polymers with phosphorylcholine functionality, and any combination thereof.

17. The method of claim 15 , wherein said bioactive material comprises stem cells.

18. A method of treating an aneurysm in the vascular wall in an individual, comprising the step of delivering to the aneurysm an endovascular clip, said clip comprising:

means for anchoring the endovascular clip on a vessel lumen side of an aneurysm, said means comprising at least two anchoring components; and

a distal self-expanding member;

wherein the distal self-expanding member comprises a mesh;

wherein the means for anchoring and distal self-expanding member comprise self-expanding material configured to have an original configuration and a deformed configuration;

wherein said means for anchoring and said distal self-expanding member are configured to extend across opposite sides of a neck of an aneurysm; and

a distal detachable wire detachably coupled to the distal self-expanding member;

wherein the distal detachable wire comprises a manually-adjustable steering joint, and

wherein the means for anchoring is disposed proximal to the distal self-expanding member with respect to a hypotube detachably coupled to the means for anchoring,

wherein said endovascular clip occludes said aneurysm.

19. The method of claim 18 , wherein the method further comprises incorporation of a swellable gel on the device for further occlusion of the aneurysm.

20. The method of claim 19 , wherein the swellable gel is selected from the group consisting of hydrogel, hydrogel foam, hydrophilic polymers with conjugated collagen, hydrophilic polymers without conjugated collagen, porous hydrated polyvinyl alcohol foam (PAF) gel, and a combination thereof.

21. The method of claim 18 , further comprising incorporation of growth factors or vascular stromal stem cells of the individual delivered to the aneurysm.