Occlusion device
Provided herein is an occlusion device for intrasaccular implantation and/or vascular occlusion comprising: (a) a substantially solid marker having a proximal end, and a distal end; and (b) a low profile resilient mesh body attached to the distal end of the marker, the body having a delivery shape and a deployed shape capable of conforming to aneurysm walls; wherein the body has a diameter greater than a diameter of an aneurysm to be treated. Also provided herein is a kit comprising the occlusion device disclosed herein and a means for delivery thereof. Methods of manufacture and use of the occlusion device disclosed herein are also disclosed.
1. A method for treating a patient comprising:
deploying within a blood vessel having vessel walls that is within the body of the patient a device comprising
(i) a substantially solid marker having a proximal end, a distal end; and
(ii) a resilient mesh body attached to the distal end of the marker,
the body having a delivery shape and a deployed shape capable of conforming to the vessel walls, wherein the body is a layer of the resilient mesh body folded over onto itself thereby forming a dual layer structure and creating a circumferential fold line around a circumference of the body, and folded over ends of the resilient mesh body, and wherein all of the folded over ends of the dual layer structure are within the marker.
2. The method of claim 1 which comprises deploying the device with a delivery system selected form the group consisting of a catheter, a micro catheter, a guide wire or a pusher wire.
3. The method of claim 1 wherein the device is detachable from the delivery system.
4. The method of claim 1 which comprises adjusting the device after delivery to conform to the walls of the blood vessel.
5. The method of claim 1 wherein the marker is a radiopaque marker.
6. The method of claim 1 wherein the marker comprises a rigid member.
7. The method of claim 1 wherein the marker comprises a solid ring.
8. The method of claim 1 wherein the body has a height that is between about 10 to 20% of its width.
9. The method of claim 1 wherein the body has a height that is between about 12 to 18% of its width.
10. A method of treating a patient which comprises implanting within a blood vessel of the patient having vessel walls a device which comprises (a) a substantially solid marker; and (b) a resilient mesh body attached to one end of the marker, the body comprising a layer of mesh folded over on itself forming a dual layer structure and forming a fold line around a circumference of the body and a plurality of folded over ends of the resilient mesh body, the body being capable of being transformed from a first delivery shape to a second deployed shape capable of conforming to the vessel walls and wherein in the deployed shape all of the folded over ends of the resilient mesh body are adjacent to one another within the marker.
11. The method of claim 10 which comprises implanting the device with a delivery system selected from the group consisting of a catheter, a micro catheter, a guide wire or a pusher wire.
12. The method of claim 11 wherein the device is non-detachable from the delivery system.
13. The method of claim 11 which comprises retrieving the device using the marker as an attachment junction.
14. The method of claim 11 wherein the marker is a solid member.
15. The method of occluding a peripheral blood vessel having vessel walls that is within the body of a patient which comprises deploying within the blood vessel a device comprising
(i) a substantially solid marker having a proximal end and a distal end; and
(ii) a resilient mesh body attached to the distal end of the marker, the body having a delivery shape and a deployed shape capable of conforming to the vessel walls
wherein the body is a layer of the resilient mesh body folded over onto itself forming a dual layer structure and creating a circumferential fold line around a circumference of the body and folded over ends of the resilient mesh body, wherein folded over ends of the resilient mesh body are within the marker.
16. The method of claim 15 which comprises implanting the device with a delivery system selected from the group consisting of a catheter, a micro catheter, a guide wire or a pusher wire.
17. The method of claim 16 wherein the marker is a solid member.
18. The method of claim 15 which comprises filling the resilient mesh body with an embolic material.
19. The method of claim 18 wherein the embolic material is a member selected from the group consisting of detachable coils and a liquid polymer.
20. The method of treating a patient to shutdown blood flow distal to a specified vascular point in a blood vessel having vessel walls which comprises deploying at the specified vascular point a device comprising
(i) a substantially solid marker having a proximal end, a distal end; and
(ii) a resilient mesh body attached to the distal end of the marker, the body having a delivery shape and a deployed shape capable of conforming to the vessel walls,
wherein the body is a layer of the resilient mesh body folded over onto itself forming a dual layer structure and creating a circumferential fold line around a circumference of the body, wherein folded over ends of the resilient mesh body are within the marker.
21. The method of claim 20 which comprises deploying the device with a delivery system selected from the group consisting of a catheter, a micro catheter, a guide wire or a pusher wire.
22. The method of claim 20 wherein the marker is a ring.
23. The method of claim 20 wherein the marker comprises a detachment junction to deploy the occlusion device.
24. The method of claim 20 wherein the resilient mesh body is configured to have a diameter greater than a diameter of the vessel to be treated and wherein the body has a height that is between about 10-20% of its width.
25. The method of 20 wherein deployment of the device causes embolization within the blood vessel.