Bakuchiol compositions for treatment of post inflammatory hyperpigmentation
Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.
1. A method for preventing, alleviating, reducing or treating excess pigmentation in a deep layer of skin resulting from a condition derived from an inflammatory skin disorder, the method comprising administering to a mammal an effective amount of a composition comprising bakuchiol, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier and less than 500 ppm total furanocoumarin impurities.
2. The method of claim 1 , wherein the composition comprises less than 100 ppm total furanocoumarin impurities.
3. The method of claim 1 , wherein the composition shows no tyrosinase inhibition activity relative to a kojic acid control.
4. The method of claim 1 , wherein the furanocoumarin impurities comprise psoralen, isopsoralen or combinations thereof.
5. The method of claim 1 , wherein the inflammatory skin disorder comprises atopic dermatitis, allergic contact dermatitis, incontinent pigmenti, lichen planus, lupus erythematosus, morphea, mechanical trauma, ionizing or nonionizing radiation, burns, laser or drug therapies, skin infection, or combinations thereof.
6. The method of claim 1 , wherein the composition comprises 0.001% to 99.9% by total weight of bakuchiol and a pharmaceutically, dermatologically or cosmetically acceptable carrier.
7. The method of claim 1 , wherein the composition is administered topically, by aerosol, by suppository, intradermically, intramuscularly or intravenously.
8. The method of claim 1 , wherein the composition is formulated for topical administration.
9. The method of claim 1 , wherein the composition comprises from about 0.1% to about 2.0% by total weight of bakuchiol.
10. The method of claim 1 , wherein the composition comprises about 0.5% by total weight of bakuchiol.
11. The method of claim 1 , wherein the method alleviates excess pigmentation.
12. The method of claim 1 , wherein the method reduces excess pigmentation.
13. The method of claim 1 , wherein the method treats excess pigmentation.
14. The method of claim 1 , wherein the excess pigmentation occurs in a papillary dermis layer of skin.
15. The method of claim 1 , further comprising reducing super oxide anion.
16. The method of claim 1 , further comprising reducing melanogenesis.
17. The method of claim 1 , further comprising reducing melanocyte proliferation.
18. The method of claim 1 , further comprising preventing melanocyte apoptosis.
19. The method of claim 1 , wherein the composition further comprises salicylic acid or a pharmaceutically acceptable salt thereof.