IP Library Granted Patent US 10,701,955
Granted Patent B2
US 10,701,955 · App. 16/655,776 · Granted Jul 7, 2020

Ruminant compositions

Inventors: Mallory Embree (San Diego, CA); Luke Picking (San Diego, CA); Grant Gogul (Cardiff, CA); Janna Tarasova (San Diego, CA)
Assignee: Ascus Biosciences, Inc.
A23K10/18A23K10/30A23K10/37A23K20/158A23K20/163A23K20/28A23K40/35A23K50/10A23L31/10A23L33/135A61K9/0019A61K9/0053A61K35/74A61K35/741A61K35/742A61K36/06A61K36/062A61K36/064A61K39/02A61P15/04A61P31/04C12N1/14C12N1/20A61K35/748
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Quick Facts
Patent No.
US 10,701,955
App. No.
16/655,776
Granted
Jul 7, 2020
Kind
B2
Abstract

The disclosure relates to compositions beneficial for ruminant administration. Particularly, the disclosure provides compositions formulated for ruminants that comprise beneficial microbes.

Claims (18)

1. A powder composition formulated for oral administration to ruminants, comprising:

a) a population of Clostridium comprising bacteria with a 16S nucleic acid sequence sharing at least 99% sequence identity to SEQ ID NO: 28; and

b) a carrier suitable for oral ruminant administration,

wherein the composition is formulated to protect the population of Clostridium from external stressors prior to entering the gastrointestinal tract of the ruminant.

2. The composition of claim 1 , wherein the population of Clostridium comprise bacteria with a 16S nucleic acid sequence comprising SEQ ID NO: 28.

3. The composition of claim 1 , wherein the composition is formulated to protect the Clostridium from moisture.

4. The composition of claim 1 , wherein the powder is dry.

5. The composition of claim 1 , wherein the composition is formulated for oral administration to a cow.

6. The composition of claim 1 , wherein the composition is further formulated as a solid, liquid, or a mixture thereof.

7. The composition of claim 1 , wherein the composition is further formulated in the form of a pellet, capsule, granulate, powder, liquid, or semi-liquid.

8. The composition of claim 1 , wherein the composition is combined with a ruminant food.

9. The composition of claim 1 , wherein the composition is combined with hay, haylage, silage, livestock feed, forage, fodder, beans, grains, micro-ingredients, fermentation compositions, mixed ration, or a mixture thereof.

10. The composition of claim 1 , wherein the composition is combined with total mixed ration.

11. The composition of claim 1 , wherein the Clostridium are present in the composition in an amount effective to increase milk production or improve milk compositional characteristics in a ruminant administered the composition, as compared to a ruminant not administered the composition.

12. The composition of claim 1 , wherein the population of Clostridium comprise bacteria deposited as NRRL B-67248 or progeny thereof.

13. The composition of claim 1 , wherein the composition is stable under ambient conditions for at least one week.

14. The composition of claim 1 , wherein the Clostridium are present in the composition in spore form.

15. The composition of claim 1 , wherein the Clostridium are present in the composition in an amount of at least 10 2 cells per gram.

Assignments (3)
SECURITY INTEREST Recorded Jul 30, 2025
From: NATIVE MICROBIALS, INC.
To: WESTERN ALLIANCE BANK
Reel/Frame 072324/0001 →
CHANGE OF NAME Recorded Sep 9, 2020
From: ASCUS BIOSCIENCES, INC.
To: NATIVE MICROBIALS, INC.
Reel/Frame 053732/0496 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 30, 2019
From: EMBREE, MALLORY; PICKING, LUKE; GOGUL, GRANT; TARASOVA, JANNA
To: ASCUS BIOSCIENCES, INC.
Reel/Frame 051387/0258 →
Continuity (8)
Continuation 16207811 · Dec 3, 2018
Continuation 16029398 · Jul 6, 2018
Continuation PCTUS2017012573 · Jan 6, 2017
Provisional Application 62415908 · Nov 1, 2016
Provisional Application 62334816 · May 11, 2016
Provisional Application 62276531 · Jan 8, 2016
Provisional Application 62276142 · Jan 7, 2016
Related Publication 20200037633A1 · Feb 6, 2020