Compositions and methods for the treatment of allergy
Provided herein are compositions and methods for the treatment of allergy, such as food allergy. Also provided herein are compositions and methods for modulating an immune response associated with allergy and/or inducing immune tolerance or desensitization to an allergy, such as a food allergy.
1. A method of treating a food allergy, comprising orally administering to a subject in need thereof a therapeutically effective amount of a composition comprising a purified bacterial mixture comprising 7 bacterial strains each comprising one of 16S rDNA sequences having at least 99.5% sequence identity to SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, or SEQ ID NO:8; wherein there is 1 strain comprising each of the 16S rDNA sequences having at least 99.5% sequence identity to SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, or SEQ ID NO: 8.
2. The method of claim 1 , wherein the subject is administered an antibiotic prior to administration of the composition.
3. The method of claim 2 , wherein the antibiotic is vancomycin.
4. The method of claim 1 , wherein the food allergy is selected from the group consisting of a nut allergy, a fish allergy, a wheat allergy, a milk allergy, a peanut allergy, a tree nut allergy, a shellfish allergy, a soy allergy, a seed allergy, a sesame seed allergy, and an egg allergy.
5. The method of claim 1 , wherein the food allergy is a peanut allergy.
6. The method of claim 1 , wherein one or more of the bacterial strains are in spore form.
7. The method of claim 1 , wherein one or more of the bacterial strains are lyophilized.
8. The method of claim 1 , wherein all of the bacterial strains are lyophilized.
9. The method of claim 1 , wherein one or more of the bacterial strains are spray-dried.
10. The method of claim 1 , wherein all of the bacterial strains are spray-dried.
11. The method of claim 1 , wherein the bacterial strains originate from more than one human donor.
12. The method of claim 1 , wherein the composition is in the form of a capsule.
13. The method of claim 1 , wherein the composition further comprises one or more enteric polymers.
14. The method of claim 1 , wherein the composition further comprises one or more adjuvants.
15. The method of claim 3 , wherein vancomycin is administered in 4 doses of 125 mg vancomycin per day for 5 days.
16. A method of treating a food allergy, comprising orally administering to a subject in need thereof a therapeutically effective amount of a composition comprising a purified bacterial mixture comprising 7 bacterial strains selected from the group consisting of Clostridium bolteae, Anaerotruncis colihominis, Eubacterium fissicatena, Clostridium symbiosum, Blautia producta, Dorea longicatena, Clostridium innocuum , and Flavinofractor plautii.
17. The method of claim 16 , wherein the subject is administered an antibiotic prior to administration of the composition.
18. The method of claim 17 , wherein the antibiotic is vancomycin.
19. The method of claim 16 , wherein the food allergy is selected from the group consisting of a nut allergy, a fish allergy, a wheat allergy, a milk allergy, a peanut allergy, a tree nut allergy, a shellfish allergy, a soy allergy, a seed allergy, a sesame seed allergy, and an egg allergy.
20. The method of claim 16 , wherein the food allergy is a peanut allergy.
21. The method of claim 16 , wherein one or more of the bacterial strains are in spore form.
22. The method of claim 16 , wherein one or more of the bacterial strains are lyophilized.
23. The method of claim 16 , wherein all of the bacterial strains are lyophilized.
24. The method of claim 16 , wherein one or more of the bacterial strains are spray-dried.
25. The method of claim 16 , wherein all of the bacterial strains are spray-dried.
26. The method of claim 16 , wherein the bacterial strains originate from more than one human donor.
27. The method of claim 16 , wherein the composition is in the form of a capsule.
28. The method of claim 16 , wherein the composition further comprises one or more enteric polymers.
29. The method of claim 16 , wherein the composition further comprises one or more adjuvants.
30. The method of claim 18 , wherein vancomycin is administered in 4 doses of 125 mg vancomycin per day for 5 days.