Granted Patent
B2
US 10,864,282 · App. 16/732,509 · Granted Dec 15, 2020
ST-246 liquid formulations and methods
Inventors:
Shanthakumar R. Tyavanagimatt (Corvallis, OR); Melialani A. C. L. S. Anderson (Corvallis, OR); William Weimers (Corvallis, OR); Gopi Krishna Kasi (Lynnwood, WA); N K Peter Samuel (Corvallis, OR); Tove C. Bolken (Keizer, OR); Dennis E. Hruby (Albany, OR)
Assignee:
Siga Technologies Inc.
A61K47/6951A61K9/0014A61K9/0019A61K9/08A61K31/4035A61K31/715A61K31/724A61K47/10A61K47/26A61K47/40C12N2710/24071
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Abstract
The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
Claims (5)
1. A process for preparing a water-soluble solid ST-246 pharmaceutical formulation comprising:
a) mixing ST-246 with cyclodextrin in a pharmaceutically acceptable liquid carrier;
b) optionally filtering the mixture of step a); and
c) lyophilizing said mixture.
2. The process of claim 1 , wherein said cyclodextrin is hydroxypropyl-β-cyclodextrin and/or sulfobutyl-ether-β-cyclodextrin.
Assignments (2)
CHANGE OF ADDRESS
Recorded Mar 25, 2026
From: SIGA TECHNOLOGIES, INC.
To: SIGA TECHNOLOGIES, INC.
Reel/Frame 075242/0438 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 2, 2020
From: TYAVANAGIMATT, SHANTHAKUMAR R.; ANDERSON, MELIALANI A.C.L.S.; WEIMERS, WILLIAM; KASI, GOPI KRISHNA; SAMUEL, N K PETER; BOLKEN, TOVE' C.; HRUBY, DENNIS E.
To: SIGA TECHNOLOGIES INC.
Reel/Frame 051399/0647 →
Continuity (7)
Division
13814102
Provisional Application
61450359
· Mar 8, 2011
Provisional Application
61370971
· Aug 5, 2010