Granted Patent
B2
US 10,995,094 · App. 16/735,910 · Granted May 4, 2021
Temozolomide compounds, polymers prepared therefrom, and method of treating a disease
Inventors:
Todd Emrick (South Deerfield, MA); Matthew Skinner (Amherst, MA); Sarah M. Ward (Amherst, MA); Banishree Saha (Greenfield, MA)
Assignee:
THE UNIVERSITY OF MASSACHUSETTS
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Abstract
A temozolomide compound according to formula (I) is described, wherein R 1 , L 1 , and X are defined herein. The temozolomide compound can be used to prepare polymers comprising temozolomide. Additionally, the polymers comprising temozolomide can be particularly useful in the treatment of certain diseases.
Claims (14)
1. A temozolomide compound of structure (I)
wherein
X is —O—;
L 1 is a divalent C 1-6 alkylene group;
n is 1; and
R 1 is an aldehyde group.
2. A temozolomide compound of structure (I)
wherein
X is —O—;
L 1 is a divalent C 1-6 alkylene group;
n is 1; and
R 1 is a ketone group
of the formula
wherein R 5 is a C 1-6 alkyl group.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Jun 4, 2020
From: UNIVERSITY OF MASSACHUSETTS, AMHERST
To: NATIONAL SCIENCE FOUNDATION
Reel/Frame 052845/0278 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 7, 2020
From: EMRICK, TODD; SKINNER, MATTHEW; WARD, SARAH M.; SAHA, BANISHREE
To: THE UNIVERSITY OF MASSACHUSETTS
Reel/Frame 051437/0848 →
Continuity (3)
Provisional Application
62398078
· Sep 22, 2016