Aminosteroids for the treatment of a PTP1B associated disease
This application is directed to the use of aminosteroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
1. A compound or pharmaceutically acceptable salt thereof selected from the group consisting of:
2. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable diluent or a pharmaceutically acceptable carrier.
3. A method of inhibiting protein tyrosine phosphatase PTP1B in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.
4. A compound of formula
or a pharmaceutically acceptable salt thereof,
wherein:
X 2 =—OH or H;
X 3 =H, —OH;
X 4 =—OH or H; and
X 5 =H or —CH 3 ; provided at least one of X 2 or X 3 is OH.
5. A method of inhibiting protein tyrosine phosphatase PTP1B in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of a compound of claim 4 , or a pharmaceutically acceptable salt thereof.
6. The method of claim 5 , wherein inhibiting protein tyrosine phosphatase PTP1B in a mammal treats diabetes.
7. A pharmaceutical composition comprising a compound of claim 4 , and a pharmaceutically acceptable diluent or a pharmaceutically acceptable carrier.