Nitric oxide topical application apparatus and methods
A topical application of nitric oxide may be provided by two separate containers, each containing an active component media to produce nitric oxide when combined. For example, a nitrite component media may be contained in one dispenser and an acidified component media may be contained in another dispenser. Each dispenser may dispense the respective component media as a foam. The resultant foams are combined to initiate the production of nitric oxide and the mixture of foams is applied topically to treat various skin disorders or wounds.
1. A method for transdermal absorption of nitric oxide comprising:
providing a first solution comprising water, at least one nitrite reactant, and a surfactant;
providing a second solution comprising water, at least one acidic reactant, and the surfactant;
dispensing a portion of the first solution;
dispensing a portion of the second solution;
mixing the portion of the first solution and the portion of the second solution to produce a resultant foam;
applying the resultant foam to a portion of skin; and
allowing the resultant foam to collapse.
2. The method of claim 1 , further comprising:
allowing the resultant foam to remain on the portion of skin for at least three minutes; and
removing any remaining resultant foam from the portion of skin.
3. The method of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, and 1 g of the surfactant; and
the second solution comprises approximately 100 mL of water, 5 g of lactic acid, 6 g of citric acid, and 3 g of the surfactant.
4. The method of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, 2 g of sodium bicarbonate, and 1 g of the surfactant, wherein the surfactant is a cationic surfactant; and
the second solution comprises approximately 100 mL of water, 5 g of lactic acid, 8 g of citric acid, and 3 g of the surfactant, wherein the surfactant is a cationic surfactant.
5. The method of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, and 2 g of the surfactant; and
the second solution comprises approximately 100 mL of water, 10 g of citric acid, and 6 g of the surfactant.
6. The method of claim 1 , wherein:
the first solution comprises approximately 100 mL of water, 10 g of sodium nitrite, 2 g of sodium bicarbonate, and 2 g of the surfactant; and
the second solution comprises approximately 100 mL of water, 5 g of ascorbic acid, 8 g of citric acid, and 6 g of the surfactant.
7. The method of claim 3 , further comprising:
allowing the resultant foam to remain on the portion of skin for at least three minutes; and
removing any remaining resultant foam from the portion of skin.
8. The method of claim 7 , wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 90% and 120% during the time the resultant foam remains on the portion of skin.
9. The method of claim 6 , further comprising:
allowing the resultant foam to remain on the portion of skin for at least three minutes; and
removing any remaining resultant foam from the portion of skin.
10. The method of claim 9 , wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70% during the time the resultant foam remains on the portion of skin.
11. A method for treating skin disorders comprising:
providing a first solution comprising approximately 100 mL of water, 10 g of a nitrite reactant, and 2 g of a surfactant;
providing a second solution comprising approximately 100 mL of water, 10 g of an acidic reactant, and 6 g of the surfactant;
dispensing a portion of the first solution;
dispensing a portion of the second solution;
mixing the portion of the first solution and the portion of the second solution to produce a resultant foam;
applying the resultant foam to a portion of skin to be treated; and
allowing the resultant foam to remain on the portion of skin for at least three minutes, wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70% during the time the resultant foam remains on the portion of skin.
12. The method of claim 11 , wherein the nitrite reactant is selected from the group consisting of sodium nitrite and potassium nitrite; and the acidic reactant is selected from the group consisting of citric acid, lactic acid, salicylic acid, phosphoric acid, and ascorbic acid; and the surfactant is selected from the group consisting of coco-betaine and cocamidopropyl betaine.
13. The method of claim 11 , wherein the first solution further comprises approximately 2 g of sodium bicarbonate.
14. The method of claim 11 , wherein the first solution further comprises a salt buffer for regulating the reaction rate of nitric oxide production.
15. A method for topical application comprising:
providing a first solution comprising approximately 100 mL of water, 10 g of a nitrite reactant, and 2 g of a surfactant;
providing a second solution comprising approximately 100 mL of water, 10 g of an acidic reactant, and 6 g of the surfactant;
dispensing a first portion of the first solution;
dispensing a second portion of the second solution;
mixing the first portion and the second portion to produce a resultant foam, wherein the mixing of the resultant foam initiates the production of nitric oxide;
applying the resultant foam to a portion of skin; and
allowing the resultant foam to collapse in response to contact with the portion of skin.
16. The method of claim 15 , further comprising, allowing the resultant foam to remain on the portion of skin for at least three minutes.
17. The method of claim 16 , wherein the resultant foam produces a nitric oxide to nitrogen dioxide ratio averaging between approximately 60% and 70% during the time the resultant foam remains on the portion of skin.
18. The method of claim 15 , wherein the first solution further comprises approximately 2 g of sodium bicarbonate.
19. The method of claim 15 , wherein the first solution further comprises a salt buffer for regulating the reaction rate of nitric oxide production.
20. The method of claim 15 , wherein the nitrite reactant is selected from the group consisting of sodium nitrite and potassium nitrite; and the acidic reactant is comprised of at least two reactants selected from the group consisting of citric acid, lactic acid, salicylic acid, phosphoric acid, and ascorbic acid; and the surfactant is selected from the group consisting of coco-betaine and cocamidopropyl betaine.