Method for treating a swallowing disorder
This invention relates to a method for treating a swallowing disorder in a patient suffering from aspiration before, during and/or after the swallowing reflex, and to a bolus for use in the treatment of a swallowing disorder in such a patient.
1. A method of treating a swallowing disorder in an individual suffering from at least one of aspiration before the swallowing reflex, aspiration after the swallowing reflex, aspiration before and during the swallowing reflex, aspiration before and after the swallowing reflex, or aspiration during and after the swallowing reflex, the method comprising:
administering a bolus to the individual, wherein the bolus is a cohesive thin liquid having (i) a shear viscosity of less than about 50 mPas when measured at a shear rate of 50 s −1 , and (ii) a relaxation time, determined by a Capillary Breakup Extensional Rheometry (CaBER) experiment, of more than 10 ms (milliseconds) at a temperature of 20° C.
2. The method according to claim 1 , wherein the bolus comprises at least one food grade biopolymer.
3. The method according to claim 2 , wherein the bolus comprises the at least one food grade biopolymer in a concentration from 0.01 wt % to 25 wt %.
4. The method according to claim 2 , wherein the bolus comprises the at least one food grade biopolymer in a concentration from 0.1 wt % to 15 wt %.
5. The method according to claim 2 , wherein the bolus comprises the at least one food grade biopolymer in a concentration from 1 wt % to 10 wt %.
6. The method according to claim 2 , wherein the at least one food grade biopolymer is selected from the group consisting of plant-extracted gums, plant-derived mucilages, and combinations thereof.
7. The method according to claim 2 , wherein the at least one food grade biopolymer comprises a plant-extracted gum selected from the group consisting of okra gum, konjac mannan, tara gum, locust bean gum, guar gum, fenugreek gum, tamarind gum, cassia gum, acacia gum, gum ghatti, pectins, cellulosics, tragacanth gum, karaya gum, and combinations thereof.
8. The method according to claim 2 , wherein the at least one food grade biopolymer comprises okra gum.
9. The method according to claim 2 , wherein the at least one food grade biopolymer comprises a plant-derived mucilage selected from the group consisting of kiwi fruit mucilage, cactus mucilage, chia seed mucilage, psyllium mucilage, mallow mucilage, flax seed mucilage, marshmallow mucilage, ribwort mucilage, mullein mucilage, cetraria mucilage, and combinations thereof.
10. The method according to claim 2 , wherein the at least one food grade biopolymer comprises at least one of kiwi fruit mucilage or cactus mucilage.
11. The method according to claim 1 , wherein the bolus comprises beta-glucan.
12. The method according to claim 1 , wherein the bolus is in an administrable form selected from the group consisting of a nutritional supplement, a full meal, a nutritionally complete formula, a pharmaceutical formulation, functional food, a beverage product, and combinations thereof.
13. The method according to claim 1 , wherein the cohesive thin liquid has a shear viscosity of from 5 to 45 mPas, when measured at a shear rate of 50 s −1 .
14. The method according to claim 1 , wherein the cohesive thin liquid has a shear viscosity of from 10 to 40 mPas, when measured at a shear rate of 50 s −1 .
15. The method according to claim 1 , wherein the cohesive thin liquid has a shear viscosity of from 20 to 30 mPas, when measured at a shear rate of 50 s −1 .
16. A method of treating a swallowing disorder in an individual suffering from at least one of aspiration after the swallowing reflex, aspiration before and during the swallowing reflex, or aspiration during and after the swallowing reflex, the method comprising:
administering a bolus to the individual, wherein the bolus is a cohesive thick liquid having (i) a shear viscosity of more than about 50 mPas when measured at a shear rate of 50 s −1 , and (ii) a relaxation time, determined by a Capillary Breakup Extensional Rheometry (CaBER) experiment, of more than 10 ms (milliseconds) at a temperature of 20° C.
17. The method according to claim 16 , wherein the cohesive thick liquid has a shear viscosity from 55 to 350 mPas when measured at a shear rate of 50 s −1 .