Granted Patent
B2
US 12,270,078 · App. 16/800,390 · Granted Apr 8, 2025
Methods for diagnosing and treating eosinophilic gastritis
Assignee:
Children's Hospital Medical Center
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Abstract
The present invention relates to methods for diagnosing, monitoring, and optionally treating eosinophilic gastritis (EG) and/or eosinophilic gastroenteritis (EGE), the methods comprising assaying one or more tissue, serum, or plasma biomarkers in a biological sample from the subject.
Claims (7)
1. A method for treating eosinophilic gastritis (EG) or eosinophilic gastroenteritis (EGE) in a subject in need thereof, the method comprising
a) determining amounts of CCL26 protein, IL-5 protein, and TSLP protein, or peptide or polypeptide fragments thereof in a serum fraction of a blood sample obtained from the subject at an initial time point;
b) detecting an elevated amount of two or more of CCL26, IL-5, and TSLP proteins, or peptide or polypeptide fragments thereof, in the serum fraction, relative to a predetermined control value;
c) diagnosing the subject as having EG or EGE; and
d) administering to the subject diagnosed with EG or EGE i) a therapeutic agent selected from the group consisting of a glucocorticoid, a leukotriene inhibitor, azathioprine, an anti-histamine, a mast-cell stabilizer, a macrolide antibiotic, and anti-cytokine therapy, or ii) a dietary therapy which alleviates one or more symptoms or complications of EG or EGE selected from a restricted diet, an elemental diet, and an elimination diet.
2. The method of claim 1 , wherein the subject is human.
3. The method of claim 1 , further comprising an initial step of obtaining a blood sample from the subject.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 19, 2024
From: ROTHENBERG, MARC E.; SHODA, TETSUO
To: CHILDREN'S HOSPITAL MEDICAL CENTER
Reel/Frame 069636/0265 →
CONFIRMATORY LICENSE
Recorded Mar 9, 2020
From: CINCINNATI CHILDRENS HOSP MED CTR
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 052121/0163 →
Continuity (3)
Provisional Application
62813838
· Mar 5, 2019
Provisional Application
62810093
· Feb 25, 2019
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