IP Library Granted Patent US 11,877,921
Granted Patent B2
US 11,877,921 · App. 16/831,169 · Granted Jan 23, 2024

Method and apparatus for creating a modified tissue graft

Inventor: Barry Markman (Frisco, TX)
Assignee: MARKMAN BIOLOGICS CORPORATION
A61F2/0077A61F2/0063A61L27/54A61F2002/0068A61F2002/0081A61F2240/002A61F2240/005A61F2250/0026A61F2250/0048A61F2250/0051A61F2250/0067
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Quick Facts
Patent No.
US 11,877,921
App. No.
16/831,169
Granted
Jan 23, 2024
Kind
B2
Abstract

In a method of creating a modified tissue graft, at least one exterior surface of a graft is modified by compressing, cutting and/or removing one or more portions thereof, such as to create designed surface features which cause the tissue graft to have characteristics for a specific anatomical area. The modified tissue graft may include a medicated graft, such as by associating medicants with the surface features, or by associating a second graft or layer with a modified base tissue graft layer, where medicants are associated with the second graft or layer. The tissue graft may be modified by pressing a specially configured template or die, such as having blades thereon, into the tissue graft, such as to create a pattern of partial depth cuts.

Claims (10)

1. A modified tissue graft prepared by the process of:

obtaining a tissue graft having a top surface and a bottom surface;

obtaining a template comprising a plurality of cutting blades and one or more stop surfaces, and

pressing said template downwardly into engagement with at least one of said top surface and said bottom surf ace of said tissue graft until said one or more stop surfaces engage said tissue graft, whereby said plurality of cutting blades create a plurality of corresponding partial-depth cuts in said tissue graft.

2. The modified tissue graft in accordance with claim 1 , wherein said plurality of blades are located in parallel rows, wherein blades in each row are spaced from one another.

3. The modified tissue graft in accordance with claim 2 , wherein blades in adjacent rows are off set from one another.

4. The modified tissue graft in accordance with claim 1 , wherein said blades are configured into a grid pattern.

5. The modified tissue graft in accordance with claim 1 , wherein said one or more stop surfaces comprises a base of said template and said plurality of blades extends outwardly from said base.

6. The modified tissue graft in accordance with claim 1 , comprising pressing said template downwardly using a pneumatic press.

7. The modified tissue graft in accordance with claim 1 , wherein said tissue graft is configured to comprise human tissue.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF APPLICANT PREVIOUSLY RECORDED ON REEL 67051 FRAME 308. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jul 16, 2025
From: MARKMAN BIOLOGICS CORPORATION
To: CELLTHERX CORP
Reel/Frame 072050/0092 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 9, 2024
From: MARKMAN BIOLOGICS CORPORATION
To: CELLTHERX
Reel/Frame 067051/0308 →
RELEASE OF SECURITY INTEREST Recorded Apr 8, 2024
From: MARKMAN, BARRY
To: MARKMAN BIOLOGICS CORPORATION
Reel/Frame 067032/0745 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 28, 2020
From: MARKMAN, BARRY
To: MARKMAN BIOLOGICS CORPORATION
Reel/Frame 053627/0213 →
SECURITY INTEREST Recorded Aug 28, 2020
From: MARKMAN BIOLOGICS CORPORATION
To: MARKMAN, BARRY
Reel/Frame 053627/0532 →
Continuity (9)
Continuation In Part 16657124 · Oct 18, 2019
Continuation In Part 16410167 · May 13, 2019
Continuation 15487585 · Apr 14, 2017
Continuation 14678188 · Apr 3, 2015
Continuation In Part 13687082 · Nov 28, 2012
Continuation 13101022 · May 4, 2011
Provisional Application 62805032 · Feb 13, 2019
Provisional Application 61331805 · May 5, 2010
Related Publication 20200222167A1 · Jul 16, 2020
Cited By (2)
US 1,101,168 US 12,458,730