IP Library Granted Patent US 11,013,742
Granted Patent B2
US 11,013,742 · App. 16/844,996 · Granted May 25, 2021

Cholesteryl ester transfer protein (CETP) inhibitor and pharmaceutical compositions comprising said inhibitor for use in the treatment or prevention of cardiovascular diseases

Inventors: John Ford (Cambridgeshire, GB); Patrick Round (Suffolk, GB); John Kastelein (Amsterdam, NL); Atsuhiro Kawaguchi (Osaka, JP); Koichi Tomiyasu (Osaka, JP); Kozo Oka (Osaka, JP)
Assignee: DEZIMA PHARMA B.V.
A61K31/506A61K9/0053
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Quick Facts
Patent No.
US 11,013,742
App. No.
16/844,996
Granted
May 25, 2021
Kind
B2
Abstract

The present invention relates to a cholesteryl ester transfer protein (CETP) inhibitor: (hereinafter referred to as Compound A) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the composition comprises a therapeutically effective amount of said Compound A CETP inhibitor.

Claims (7)

1. A solid, oral pharmaceutical composition, comprising 5 to 10 mg of compound A:

or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient, wherein the composition is formulated for once a day administration.

2. The pharmaceutical composition according to claim 1 , comprising 5 mg or 10 mg of Compound A.

3. The pharmaceutical composition according to claim 1 , wherein the composition is formulated as a tablet or capsule.

4. The pharmaceutical composition according to claim 1 , comprising a salt of Compound A, wherein the salt is a calcium, potassium or sodium salt.

5. The pharmaceutical composition according to claim 1 , comprising 5 mg of Compound A.

6. The pharmaceutical composition according to claim 1 , comprising 10 mg of Compound A.

Assignments (4)
CHANGE OF NAME Recorded Jun 9, 2022
From: DEZIMA PHARMA B.V.
To: NEWAMSTERDAM PHARMA B.V.
Reel/Frame 060379/0089 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2021
From: FORD, JOHN; ROUND, PATRICK; KASTELEIN, JOHN
To: DEZIMA PHARMA B.V.
Reel/Frame 055597/0073 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2021
From: KAWAGUCHI, ATSUHIRO; TOMIYASU, KOUICHI; OKA, KOUZOU
To: MITSUBISHI TANABE PHARMA CORPORATION
Reel/Frame 055596/0934 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2021
From: MITSUBISHI TANABE PHARMA CORPORATION
To: DEZIMA PHARMA B.V.
Reel/Frame 055597/0147 →
Continuity (2)
Division 15117154
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Cited By (4)
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