Antibacterial compounds
The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.
1. A process for preparing 6-chloro-2-ethyl-N-({4-[2-(trifluoromethanesulfonyl)-2-azaspiro[3.3]heptan-6-yl]phenyl}methyl)imidazo[1,2-a]pyridine-3-carboxamide, which comprises converting intermediate FF,
or a salt thereof, to 6-chloro-2-ethyl-N-({4-[2-(trifluoromethanesulfonyl)-2-azaspiro[3.3]heptan-6-yl]phenyl}methyl)imidazo[1,2-a]pyridine-3-carboxamide.
2. The process as claimed in claim 1 , wherein the intermediate FF is in the form of a HCl salt.
3. The process as claimed in claim 1 , wherein the converting is performed in the presence of Tf 2 O.
4. The process as claimed in claim 3 , wherein the intermediate FF is prepared by deprotection of intermediate FE,
5. The process as claimed in claim 4 , wherein the intermediate FE is prepared by reaction of intermediate FD,
with the following compound,
6. The process for the preparation of 6-chloro-2-ethyl-N-({4-[2-(trifluoromethanesulfonyl)-2-azaspiro[3.3]heptan-6-yl]phenyl}methyl)imidazo[1,2-a]pyridine-3-carboxamide, which comprises a process according to the following scheme:
7. A compound intermediate FF:
8. The process as claimed in claim 2 , wherein the converting is performed in the presence of Tf 2 O.
9. The process as claimed in claim 1 , wherein the intermediate FF is prepared by deprotection of intermediate FE,
10. The process as claimed in claim 2 , wherein the intermediate FF is prepared by deprotection of intermediate FE,
11. The process as claimed in claim 8 , wherein the intermediate FF is prepared by deprotection of intermediate FE,
12. The process as claimed in claim 9 , wherein the intermediate FE is prepared by reaction of intermediate FD,
with the following compound,
13. The process as claimed in claim 10 , wherein the intermediate FE is prepared by reaction of intermediate FD,
with the following compound,
14. A process as claimed in claim 11 , wherein the intermediate FE is prepared by reaction of intermediate FD,
with the following compound,