Method of treating metabolic disorders and depression with dopamine receptor agonists
This invention relates to methods and formulations for treating metabolic disorders and depression. In some embodiments, the methods comprise administering a dopamine receptor agonist and an anti-depressant.
1. A method of simultaneously treating a patient afflicted with (i) a cardiovascular disease that is a member selected from the group consisting of arteriosclerosis, coronary artery disease, cerebrovascular disease and peripheral vascular disease and (ii) depression for the cardiovascular disease and depression comprising administering to a patient in need of such treatment a therapeutically effective amount of a dopamine receptor agonist selected from the group consisting of lisuride, terguride, dihydroergotoxine (hydergine), and bromocriptine at a predetermined time of day and wherein the pre-determined time of day is in the morning.
2. The method of claim 1 , wherein the pre-determined time of day in the morning is upon waking.
3. The method of claim 2 , wherein the pre-determined time of day upon waking is within 0400 to 1200 hours.
4. The method of claim 1 wherein the effective amount is between 0.5 to 300 μg/kg/day.
5. The method of claim 4 wherein the effective amount is between 0.5 and 250 μg/kg/day.
6. The method of claim 4 , which comprises parenterally administering the dopamine agonist.
7. The method of claim 6 wherein the parenteral administration is oral administration.
8. The method of claim 7 wherein the oral administration is sublingual administration.
9. The method of claim 1 wherein the dopamine receptor agonist is bromocriptine.
10. The method of claim 1 , wherein the pre-determined time of day in the morning is within 0400 to 1200 hours.
11. The method of claim 1 , which comprises parenterally administering the dopamine agonist.
12. The method of claim 11 wherein the parenteral administration is oral administration.
13. The method of claim 12 wherein the oral administration is sublingual administration.
14. The method of claim 1 wherein the effective amount is administered in a single dose of about 0.01 to about 50.0 mg of dopamine agonist.
15. A method comprising simultaneously treating a patient afflicted with (i) a cardiovascular disease that is a member selected from the group consisting of arteriosclerosis, coronary artery disease, cerebrovascular disease and peripheral vascular disease and (ii) depression for the cardiovascular disease and depression by administering to a patient in need of such treatment a therapeutically effective amount of a dopamine receptor agonist selected from the group consisting of lisuride, terguride, dihydroergotoxine (hydergine) and bromocriptine at a predetermined time of day and wherein the predetermined time of day is before bedtime and the dopamine agonist is released substantially within 2 hours of waking.
16. The method of claim 1 wherein the cardiovascular disease is arteriosclerosis.
17. The method of claim 1 wherein the cardiovascular disease is coronary artery disease.
18. The method of claim 1 wherein the dopamine receptor agonist is lisuride.
19. The method of claim 15 wherein the dopamine receptor agonist is bromocriptine.
20. The method of claim 15 wherein the effective amount is between 0.5 to 300 μg/kg/day.
21. The method of claim 20 wherein the effective amount is between 0.5 to 250 μg/kg/day.
22. The method of claim 15 , wherein the cardiovascular disease is arteriosclerosis.
23. The method of claim 15 wherein the cardiovascular disease is coronary artery disease.