Granted Patent B2

US 12,318,451 · App. 18/107,162 · Granted Jun 3, 2025

Inventor: Anthony H. Cincotta (Tiverton, RI)

Assignee: VeroScience LLC

A61K41/0057A61K31/336A61K31/519A61P35/00

Abstract

Claims (28)

1. A method of treating a pancreatic cancer tumor in a subject comprising:

1) administering at least one of glucose, glucagon, corticosteroids, growth hormones, thyroid hormones and insulin, to the subject until the plasma glucose level of the subject is raised to a level above the basal plasma glucose level of the subject;

2) administering at least one photosensitizer selected from the group consisting of benzophenoxazinium, benzophenothiazinium, and benzophenos-elenazinium dyes to the subject; and thereafter

3) exposing the tumor to actinic light between about 10 minutes and one week after the plasma glucose level of the subject has been raised to a level above the basal plasma glucose of the subject.

2. The method of claim 1 , which comprises administering at least one of glucose, glucagon, corticosteroids, growth hormones, thyroid hormones and insulin, to the subject until the plasma glucose level of the subject is at least 10% above the basal plasma glucose level of the subject.

3. The method of claim 1 , which comprises administering glucose to the subject.

4. The method of claim 1 , comprising administering one or more hormones to the subject.

5. The method of claim 1 , comprising waiting at least 30 minutes between administration of the at least one photosensitizer to the subject and exposing the tumor to actinic light.

6. The method of claim 1 , comprising increasing the plasma glucose level of the subject by at least 15, 20, 25, 30, 35, 40, 45 or 50% above the basal plasma glucose level of the subject.

7. The method of claim 1 , wherein the actinic light comprises light in the range of wavelength 600-700 nm.

8. The method of claim 1 , which comprises administering to the subject between about 0.01 to 15 mg/kg of body weight of one photosensitizer selected from the group consisting of benzophenoxazinium, benzophenothiazinium, and benzophenoselenazinium dyes.

9. The method of claim 1 , wherein the actinic light comprises laser light.

10. The method of claim 1 , wherein the actinic light delivers total light energy of between about 50 and about 500 Joules (J)/cm2.

11. The method of claim 1 , which comprises administering to the subject the at least one photosensitizer selected from the group consisting of benzophe-noxazinium, benzophenothiazinium, and benzophenoselenazinium dyes at a rate that creates a Tmax of the at least one photosensitizer within about 10-240 minutes after administration.

12. The method of claim 1 , wherein the power density of the actinic light is between about 50 and 500 mW/cm.

13. The method of claim 1 , wherein the time period after glucose administration and exposure to actinic light is between about 30 to 60 minutes.

14. The method of claim 1 , comprising administering glucagon to the subject.

15. The method of claim 1 , comprising administering corticosteroids to the subject.

16. The method of claim 1 , comprising administering growth hormones to the subject.

17. The method of claim 1 , comprising administering thyroid hormones to the subject.

18. The method of claim 1 , comprising administering insulin to the subject.

19. The method of claim 1 , comprising administering glucose and insulin to the subject.

20. The method of claim 1 , wherein the photosensitizer is 2-iodo-5-ethylamino-9-diethylamino-benzo[a]phenothiazinium chloride.

21. The method of treating pancreatic cancer in a subject in need of such treatment which comprises i) raising the plasma glucose level of the subject to a level above the subjects basal plasma glucose level by administering at least one of glucose, glucagon, corticosteroids, growth hormones, thyroid hormones and insulin to the subject until the plasma glucose level of the subject is raised to a level above the basal plasma glucose level of the subject, ii) administering at least one photosensitizer selected from the group consisting of benzophenoxazinium, benzophenothiazinium, and benzophenoselenazinium dyes to the subject, iii) maintaining the plasma glucose level of the subject above the basal plasma glucose level of the subject until exposure of the tumor to actinic light, and iv) exposing the tumor to actinic light after the plasma glucose level of the subject has been raised to a level above the basal plasma glucose of the subject.

22. The method of claim 21 , wherein the actinic light delivers total light energy of between about 50 and about 500 Joules (J)/cm 2 .

23. The method of claim 22 , which comprises administering glucose and insulin to the subject to raise the subject's plasma glucose level.

24. The method of claim 23 , which comprises administering only glucose to the subject to raise the plasma glucose level of the subject to a level above the basal plasma glucose level of the subject.

25. The method of claim 21 , which comprises administering at least one of glucose, glucagon, corticosteroids, growth hormones, thyroid hormones and insulin, to the subject until the plasma glucose level of the subject is at least 10% above the basal plasma glucose level of the subject.

Assignments (1)

Continuity (3)

References Cited (243)