Compositions for use in stimulating bone growth
The present invention relates to use of a composition for maintenance of bone and/or cartilage health or prevention, alleviation and/or treatment of bone and/or cartilage disorders.
1. A method of potentiating effects of oleuropein on bone formation and/or cartilage anabolism, the method comprising orally administering an effective amount of a composition consisting essentially of vitamin D and oleuropein to an individual in need thereof, wherein the effective amount of the composition comprises 800 to 1,200 IU of the Vitamin D, and the composition is administered to the individual at least once per day, for a time period of at least one month.
2. The method of claim 1 , wherein the effective amount of the composition comprises 850 to 1,000 IU of the Vitamin D.
3. The method of claim 1 , wherein the effective amount of the composition comprises 900 to 950 IU of the Vitamin D.
4. The method of claim 1 , wherein the effective amount of the composition comprises 0.01 mg to 1 g of the oleuropein.
5. The method of claim 1 , wherein the effective amount of the composition comprises 0.1 mg to 1 g of the oleuropein.
6. The method of claim 1 , wherein the effective amount of the composition comprises 1.0 mg to 1 g of the oleuropein.
7. The method of claim 1 , wherein the individual has a disorder linked to an imbalance in the relationship between bone formation and/or cartilage anabolism and bone resorption, and the effective amount of the composition potentiates stimulation of cartilage anabolism in the individual.
8. The method of claim 7 , wherein the disorder is osteoporosis.
9. The method of claim 1 , wherein the effective amount of the composition maintains and/or improves mobility in the individual.
10. A method of treatment and/or alleviation of a disorder linked to an imbalance in bone and/or cartilage metabolism, the method comprising orally administering an effective amount of a composition consisting essentially of Vitamin D and oleuropein to an individual having the disorder, wherein the effective amount of the composition comprises 800 to 1,200 IU of the Vitamin D, and the composition is administered to the individual at least once per day, for a time period of at least one month.
11. The method of claim 10 , wherein the effective amount of the composition comprises 850 to 1,000 IU of the Vitamin D.
12. The method of claim 10 , wherein the effective amount of the composition comprises 900 to 950 IU of the Vitamin D.
13. The method of claim 10 , wherein the effective amount of the composition comprises 0.01 mg to 1 g of the oleuropein.
14. The method of claim 10 , wherein the effective amount of the composition comprises 0.1 mg to 1 g of the oleuropein.
15. The method of claim 10 , wherein the effective amount of the composition comprises 1.0 mg to 1 g of the oleuropein.
16. The method of claim 10 , wherein the composition is a pharmaceutical composition consisting of the Vitamin D, the oleuropein and at least one excipient.
17. The method of claim 10 , wherein the disorder is osteoporosis.
18. The method of claim 10 , wherein the effective amount of the composition maintains and/or improves mobility in the individual.