Granted Patent
B2
US 10,851,066 · App. 16/888,040 · Granted Dec 1, 2020
2-arylbenzimidazoles as PPARGC1A activators for treating neurodegenerative diseases
Inventors:
Samuel D. Banister (Castle Hill, AU); Edgar Engleman (Redwood City, CA); Khoa D. Nguyen (Redwood City, CA); Mark Smith (Redwood City, CA)
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Abstract
The compound 2-(3-tert-Butylphenyl)-4,6-difluoro-1H-benzo[d]imidazole and its use are disclosed: The compound activates Ppargc1a and, as a consequence, is useful for treating neuroinflammation and for treating a variety of neurodegenerative diseases.
Claims (5)
1. A compound of formula:
2. A compound according to claim 1 , in free base form.
3. A compound according to claim 1 , in the form of a pharmaceutically acceptable salt.
4. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to claim 2 .
5. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to claim 3 .
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 2, 2020
From: BANISTER, SAMUEL D.; ENGLEMAN, EDGAR; NGUYEN, KHOA D.; SMITH, MARK
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 052806/0236 →
Continuity (3)
Continuation
PCTUS2019045229
· Aug 6, 2019
Provisional Application
62714962
· Aug 6, 2018
Cited By (2)