β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment
A compound of the structure: or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to an HCV virus or other disorders more fully described herein.
1. A pharmaceutical composition comprising an effective therapeutic amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.
2. The pharmaceutical composition of claim 1 , comprising a compound of the formula:
or a pharmaceutically acceptable salt thereof.
3. The pharmaceutical composition of claim 1 , comprising a compound of the formula:
or a pharmaceutically acceptable salt thereof.
4. The pharmaceutical composition of claim 1 , in a dosage form.
5. The pharmaceutical composition of claim 4 , in a solid dosage form.
6. The pharmaceutical composition of claim 5 , in a solid oral dosage form.
7. The pharmaceutical composition of claim 6 , in a tablet.
8. The pharmaceutical composition of claim 6 , in a capsule.
9. The pharmaceutical composition of claim 2 , in a dosage form.
10. The pharmaceutical composition of claim 9 , in a solid dosage form.
11. The pharmaceutical composition of claim 9 , in a solid oral dosage form.
12. The pharmaceutical composition of claim 11 , in a tablet.
13. The pharmaceutical composition of claim 11 , in a capsule.
14. The pharmaceutical composition of claim 3 , in a dosage form.
15. The pharmaceutical composition of claim 14 , in a solid dosage form.
16. The pharmaceutical composition of claim 14 , in a solid oral dosage form.
17. The pharmaceutical composition of claim 16 , in a tablet.
18. The pharmaceutical composition of claim 16 , in a capsule.
19. A pharmaceutical composition comprising an effective therapeutic amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.
20. The pharmaceutical composition of claim 18 , comprising a compound of the formula:
or a pharmaceutically acceptable salt thereof.
21. The pharmaceutical composition of claim 18 , comprising a compound of the
formula:
or a pharmaceutically acceptable salt thereof.
22. The pharmaceutical composition of claim 19 , in a dosage form.
23. The pharmaceutical composition of claim 22 , in a solid dosage form.
24. The pharmaceutical composition of claim 22 , in a solid oral dosage form.
25. The pharmaceutical composition of claim 24 , in a tablet.
26. The pharmaceutical composition of claim 24 , in a capsule.
27. The pharmaceutical composition of claim 20 , in a dosage form.
28. The pharmaceutical composition of claim 27 , in a solid dosage form.
29. The pharmaceutical composition of claim 27 , in a solid oral dosage form.
30. The pharmaceutical composition of claim 29 , in a tablet.
31. The pharmaceutical composition of claim 29 , in a capsule.
32. The pharmaceutical composition of claim 21 , in a dosage form.
33. The pharmaceutical composition of claim 32 , in a solid dosage form.
34. The pharmaceutical composition of claim 32 , in a solid oral dosage form.
35. The pharmaceutical composition of claim 34 , in a tablet.
36. The pharmaceutical composition of claim 34 , in a capsule.