Granted Patent
B2
US 12,697,318 · App. 16/953,129 · Granted Aug 4, 2026
Anti-inflammatory agent containing rare fatty acid
Inventors:
Jun Ogawa (Kyoto, JP); Shigenobu Kishino (Kyoto, JP); Teruo Kawada (Kyoto, JP); Nobuyuki Takahashi (Kyoto, JP); Tsuyoshi Goto (Kyoto, JP); Tatsuya Sugawara (Kyoto, JP); Yasunori Yonejima (Muko, JP)
Assignee:
Noster Inc.
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Abstract
The present invention provides an anti-inflammatory agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the anti-inflammatory agent.
Claims (3)
1 . A method for inducing differentiation of macrophage into M2 macrophage, comprising administering to a patient an effective amount of a fatty acid, wherein the fatty acid is 13-hydroxy-cis-9, cis-15-octadecadienoic acid or 13-oxo-cis-6, cis-9-octadecadienoic acid.
2 . The method according to claim 1 , wherein the fatty acid is 13-hydroxy-cis-9,cis-15-octadecadienoic acid.
3 . The method according to claim 1 , wherein the fatty acid is 13-oxo-cis-6,cis-9-octadecadienoic acid.
Assignments (4)
CORRECTIVE ASSIGNMENT TO CORRECT THE THE PROPERTY TYPE FROM APPLICATION NUMBER TO PATENT NUMBER FOR 10952983 AND 10975397 PREVIOUSLY RECORDED AT REEL: 68851 FRAME: 663. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT.
Recorded Oct 18, 2024
From: KYOTO UNIVERSITY
To: NOSTER INC.
Reel/Frame 069207/0122 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 18, 2024
From: OGAWA, JUN; KISHINO, SHIGENOBU; KAWADA, TERUO; TAKAHASHI, NOBUYUKI; GOTO, TSUYOSHI; SUGAWARA, TATSUYA; YONEJIMA, YASUNORI
To: KYOTO UNIVERSITY; NITTO PHARMACEUTICAL INDUSTRIES, LTD.
Reel/Frame 068943/0015 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 9, 2024
From: KYOTO UNIVERSITY
To: NOSTER INC.
Reel/Frame 068851/0663 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 14, 2021
From: NITTO PHARMACEUTICAL INDUSTRIES, LTD.
To: NOSTER INC.
Reel/Frame 055920/0263 →
Priority Claims (2)
JP 2014-011866
· Jan 24, 2014
· national
JP 2014-162982
· Aug 8, 2014
· national
Continuity (2)
Related Publication
20210069141A1
· Mar 11, 2021
References Cited (69)
US 4908384A
· Ho
· 1990
[cited by examiner]
US 5260336A
· Forse
· 1993
[cited by examiner]
US 9707200B2
· Ogawa et al.
· 2017
[cited by applicant]
US 20100035989A1
· Schwartz et al.
· 2010
[cited by applicant]
US 20110190389A1
· Arterburn
· 2011
[cited by examiner]
US 20170000752A1
· Ogawa et al.
· 2017
[cited by applicant]
CN 101611894A
· 2009
[cited by examiner]
CN 102458391A
· 2012
[cited by applicant]
JP 3103274B2
· 2000
[cited by examiner]
JP 2003073329A
· 2003
[cited by examiner]
JP 2005008594A
· 2005
[cited by applicant]
JP 2009051732A
· 2009
[cited by applicant]
JP 2009545527A
· 2009
[cited by applicant]
JP 2011184411A
· 2011
[cited by applicant]
KR 100793081B1
· 2008
[cited by examiner]
KR 101281470B1
· 2013
[cited by examiner]
WO WO9310776A1
· 1993
[cited by examiner]
WO WO9600584A1
· 1996
[cited by examiner]
WO WO1999016435A1
· 1999
[cited by applicant]
WO WO2004002234A1
· 2004
[cited by examiner]
WO WO2004084829A2
· 2004
[cited by examiner]
WO WO2007069758A1
· 2007
[cited by examiner]
WO WO2012023254A1
· 2012
[cited by applicant]
WO WO2013003689A2
· 2013
[cited by examiner]
WO WO2013168310A1
· 2013
[cited by applicant]
WO WO2014069227A1
· 2014
[cited by applicant]
WO WO2014129384A1
· 2014
[cited by applicant]
Haviv et al. (Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8, 11,13-tetraenoic acid analogs. Journal of Medicinal Chemistry vol. 30 Issue: 2 pp. 254-263 Journal; Comparative Study; …
[cited by examiner]
Herrmann et al. (“Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus.” Arthritis & Rheumatism 41.7 (1998): 1241-1250.
[cited by examiner]
Peng et al. (Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases. Mediators Inflamm. Jun. 8, 2023;2023:8821610. doi: 10.1155/2023/8821610. PMID: 37332618; PMCID: PMC10270764.
[cited by examiner]
Boddu et al., “Anti-inflammatory effects of a novel ricinoleic acid poloxamer gel system for transdermal delivery,”
[cited by applicant]
Cipollina et al., “Cyclooxygenase-2 Generates Anti-inflammatory Omega-3 fatty acid Derivatives in Activated Macrophages,”
[cited by applicant]
Haas et al., “Simplifying biodiesel production: The direct or in situ transesterification of algal biomass,”
[cited by applicant]
Kim et al., “9-oxo-10(E), 12(E)-octadecadienoic acid derived from tomato is a potent PPARα agonist to decrease triglyceride accumulation in mouse primary hepatocytes,”
[cited by applicant]
Kim et al., “Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice,”
[cited by applicant]
Kishino et al., “Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition,”
[cited by applicant]
Murakami et al., “New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: Suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARγ-, dependent pat…
[cited by applicant]
Tanabe et al., “Production of unique hydroxy fatty acid using lactic acid bacteria,”
[cited by applicant]
Tunaru et al., “Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP
[cited by applicant]
Vieira et al., “Effect of ricinoleic acid in acute and subchronic experimental models of inflammation,”
[cited by applicant]
China National Intellectual Property Administration, Search Report in Chinese Patent Application No. 20158005505.X (Feb. 15, 2019).
[cited by applicant]
Japanese Patent Office, International Search Report in International Patent Application No. PCT/JP2015/051844 (Apr. 28, 2015).
[cited by applicant]
U.S. Appl. No. 15/113,714, filed Jul. 22, 2016.
[cited by applicant]
Grechkin et al., “The lipoxygenase pathway in tulip (
[cited by applicant]
Nakajima et al., “Synthesis of 13-Oxo-(Z)-9-octadecenoic Acid and 15-Oxo-(Z)-11-icosenoic Acid, Arrestants of
[cited by applicant]
Shiraki et al., “α,β-Unsaturated Ketone Is a Core Moiety of Natural Ligands for Covalent Binding to Peroxisome Proliferator-activated Receptor γ,”
[cited by applicant]
Belarbi et al., “TNF-α Protein Synthesis Inhibitor Restores Neuronal Function and Reverses Cognitive Deficits Induced by Chronic Neuroinflammation,”
[cited by applicant]
De Meyer et al., “Therapeutic Strategies to Deplete Macrophages in Atherosclerotic Plaques,”
[cited by applicant]
Galanos et al., “Mechanisms of Endotoxin Shock and Endotoxin Hypersensitivity,”
[cited by applicant]
Han et al., “Influence of Mild Hypothermia on Inducible Nitric Oxide Synthase Expression and Reactive Nitrogen Production in Experimental Stroke and Inflammation,”
[cited by applicant]
Kasraie et al., “Role of Macrophages in the Pathogenesis of Atopic Dermatitis,”
[cited by applicant]
Kinne et al., “Macrophages in Rheumatoid Arthritis,”
[cited by applicant]
Li et al., “Microglia-Derived Macrophages in Early Multiple Sclerosis Plaques,”
[cited by applicant]
Martin et al., “Resident Macrophages Initiating and Driving Inflammation in a Monosodium Urate Monohydrate Crystal-Induced Murine Peritoneal Model of Acute Gout,”
[cited by applicant]
Nikolic-Paterson et al., “The Role of Macrophages in Glomerulonephritis,”
[cited by applicant]
Sugimoto et al., “Non-targeted Metabolite Profiling in Activated Macrophage Secretion,”
[cited by applicant]
Watanabe et al., “Hepatocellular Oxidative DNA Injury Induced by Macrophage-Derived Nitric Oxide,”
[cited by applicant]
Arora et al., “The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock,”
[cited by applicant]
Lin et al., “Stefin B alleviates the gouty arthritis in mice by inducing the M2 polarization of macrophages,”
[cited by applicant]
Weng et al., “Phenotypic Screening-Based Identification of 3,4-Disubstituted Piperidine Derivatives as Macrophage M2 Polarization Modulators: An Opportunity for Treating Multiple Sclerosis,”
[cited by applicant]
Wu et al., “Akt2 Affects Periodontal Inflammation via Altering the M1/M2 Ratio,”
[cited by applicant]
Yao et al., “Microglial polarization: novel therapeutic mechanism against Alzheimer's disease,”
[cited by applicant]
Zheng et al., “Exosomes from LPS-stimulated macrophages induce neuroprotection and functional improvement after ischemic stroke by modulating microglial polarization,”
[cited by applicant]