Anti-inflammatory metabolite derived from omega-3-type fatty acid
The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.
1. A compound selected from the group consisting of:
hydrates of the compound, pharmaceutically acceptable salts of the compound, and hydrates of the salts; wherein,
when
is a single bond,
P 1 is hydrogen, alkyl, or hydroxy and
R 1 is hydrogen, or substituted or unsubstituted, branched or unbranched alkyl;
when
is a double bond, P 1 and R 1 are not present;
X is —C(O)OR 2 ;
R 2 is a hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted aryl; and
double bonds of the compound may each be independently in either a cis or trans configuration.
2. The compound according to claim 1 , selected from the group consisting of:
or hydrates of the compound, pharmaceutically acceptable salts of the compound, and hydrates of the salts.
3. A neutrophil suppressant composition comprising a compound according to claim 1 , a hydrate of the compound, a pharmaceutically acceptable salt of the compound, or a hydrate of the salt.
4. A pharmaceutical composition comprising a compound according to claim 1 , a hydrate of the compound, a pharmaceutically acceptable salt of the compound, or a hydrate of the salt.
5. The compound according to claim 1 , which is:
or hydrates of the compound, pharmaceutically acceptable salts of the compound, and hydrates of the salts.
6. The compound according to claim 1 , which is:
or hydrates of the compound, pharmaceutically acceptable salts of the compound, and hydrates of the salts.
7. The compound according to claim 1 , which is:
or hydrates of the compound, pharmaceutically acceptable salts of the compound, and hydrates of the salts.
8. The compound according to claim 1 , which is:
or hydrates of the compound, pharmaceutically acceptable salts of the compound, and hydrates of the salts.
9. The compound according to claim 1 , which is:
or hydrates of the compound, pharmaceutically acceptable salts of the compound, and hydrates of the salts.
10. A neutrophil suppressant composition comprising a compound according to claim 2 , a hydrate of the compound, a pharmaceutically acceptable salt of the compound, or a hydrate of the salt.
11. A pharmaceutical composition comprising a compound according to claim 2 , a hydrate of the compound, a pharmaceutically acceptable salt of the compound, or a hydrate of the salt.