Granted Patent
B2
US 12,576,055 · App. 16/965,629 · Granted Mar 17, 2026
Disease detection and treatment based on trimethyl-lysine levels
Inventors:
Stanley L. Hazen (Pepper Pike, OH); Zeneng Wang (Shaker Heights, OH); Xinmin S. Li (Cleveland, OH)
Assignee:
The Cleveland Clinic Foundation
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Abstract
The present invention relates to systems, kits, and methods for identifying subjects with increased levels of N6-trimethyl-lysine (TML) or the combination of TML and trimethylamine-n-oxide (TMAO), as well as methods of determining risk of disease (e.g., kidney disease or heart failure) based on such levels. In certain embodiments, subjects with elevated TML, or TML and TMAO are treated with a therapeutic (e.g., one that inhibits the TMA/FMO3/TMAO pathway).
Claims (5)
1 . A method of treating chronic kidney disease comprising:
a) identifying a subject as having chronic kidney disease based on: i) having increased levels of N6-trimethyl-lysine (TML) compared to a control level, or having increased levels of TML and trimethylamine-n-oxide (TMAO) compared to control levels, and
b) treating said subject with a first agent or first procedure that inhibits the TMA/FMO3/TMAO pathway.
2 . The method of claim 1 , wherein said first agent that inhibits the TMA/FMO3/TMAO pathway is selected from a compound comprising: a halomethyl betaine, a halomethyl betaine salt, a halomethyl betaine amide, and a halomethyl dimethyl amino alcohol.
3 . The method of claim 1 , wherein said first agent that inhibits the TMA/FMO3/TMAO pathway is a compound comprising a halomethyl choline.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Oct 13, 2023
From: CLEVELAND CLINIC FOUNDATION
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065238/0135 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 13, 2021
From: HAZEN, STANLEY L.; WANG, ZENENG; LI, XINMIN S.
To: THE CLEVELAND CLINIC FOUNDATION
Reel/Frame 054900/0337 →
Continuity (2)
Provisional Application
62624969
· Feb 1, 2018
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