IP Library Granted Patent US 12,194,152
Granted Patent B2
US 12,194,152 · App. 16/975,643 · Granted Jan 14, 2025

Shell composition and capsule using the shell composition

Inventors: Shinya Kurihara (Fujinomiya Shizuoka, JP); Makoto Miwa (Fujinomiya Shizuoka, JP); Tomokazu Okayama (Fujinomiya Shizuoka, JP); Keiichi Kubota (Fujinomiya Shizuoka, JP); Takanori Kobayashi (Fujinomiya Shizuoka, JP); Rei Iwata (Chuo Tokyo, JP); Kenta Yamanishi (Toyonaka Osaka, JP)
Assignees: Sunsho Pharmaceutical Co., Ltd.; MP Gokyo Food & Chemical Co., Ltd.
A61K9/4816A23L29/219A23L29/238A23L29/27A23P10/30A23V2002/00
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Quick Facts
Patent No.
US 12,194,152
App. No.
16/975,643
Granted
Jan 14, 2025
Kind
B2
Abstract

Provided is a shell composition that is formed with a water-insoluble powder such as starch and/or a water-soluble polymer such as dextrin as a base component, and with locust bean gum and/or xanthan gum as a gelling agent. This shell composition enables a novel shell composition which can favorably form a shell without using carrageenan, has favorable properties that enable the shell composition to substitute traditional shells that use a gelatin shell or carrageenan, and comprises a plant-derived base.

Claims (43)

1. A shell composition formed with:

a plant-derived water-insoluble powder;

a plant-derived water-soluble polymer;

locust bean gum; and

xanthane gum, wherein

the shell composition is a soft capsule shell composition,

a ratio of a weight of the plant-derived water-insoluble powder divided by a weight of the plant-derived water-soluble polymer is in a range equal to or greater than 20/80 and equal to or less than 50/50,

a ratio of a weight of the locust beam gum divided by a weight of the xanthan gum is in a range equal to or greater than 20/80 and equal to or less than 70/30,

a total of the locust bean gum and the xanthan gum is in an amount of 10 to 30 parts by weight relative to 100 parts by weight of a total of the plant-derived water-insoluble powder and the plant-derived water-soluble polymer, and

the plant-derived water-insoluble powder includes starch.

2. The shell composition according to claim 1 , wherein the shell composition includes no animal-derived material and no carrageenan.

3. The shell composition according to claim 1 , wherein the starch includes at least one of distarch phosphate and heat-moisture-treated starch.

4. The shell composition according to claim 3 , wherein the starch includes the distarch phosphate, and the distarch phosphate includes at least one of etherified distarch phosphate and esterified distarch phosphate.

5. The shell composition according to claim 4 , wherein the distarch phosphate includes the etherified distarch phosphate, and the etherified distarch phosphate includes hydroxypropyl distarch phosphate.

6. The shell composition according to claim 1 , wherein the plant-derived water-soluble polymer includes at least one of a starch decomposition product and polydextrose.

7. A capsule preparation comprising:

a shell composition formed with:

a plant-derived water-insoluble powder;

a plant-derived water-soluble polymer;

locust bean gum; and

xanthane gum; and

an orally-administrable article encapsulated in the shell composition, wherein

the shell composition is a soft capsule shell composition,

a ratio of a weight of the plant-derived water-insoluble powder divided by a weight of the plant-derived water-soluble polymer is in a range equal to or greater than 20/80 and equal to or less than 50/50,

a ratio of a weight of the locust beam gum divided by a weight of the xanthan gum is in a range equal to or greater than 20/80 and equal to or less than 70/30,

a total of the locust bean gum and the xanthan gum is in an amount of 10 to 30 parts by weight relative to 100 parts by weight of a total of the plant-derived water-insoluble powder and the plant-derived water-soluble polymer, and

the plant-derived water-insoluble powder includes starch.

8. The capsule preparation according to claim 7 , wherein the orally-administrable article is food.

9. The capsule preparation according to claim 7 , wherein the orally-administrable article is a drug.

10. A method for manufacturing a shell composition, comprising:

preparing a shell solution with:

water;

a plant-derived water-insoluble powder;

a plant-derived water-soluble polymer;

locust bean gum; and

xanthane gum; and

gelatinizing the shell solution to obtain the shell composition, the shell composition being a soft capsule shell composition, wherein

a ratio of a weight of the plant-derived water-insoluble powder divided by a weight of the plant-derived water-soluble polymer is in a range equal to or greater than 20/80 and equal to or less than 50/50,

a ratio of a weight of the locust beam gum divided by a weight of the xanthan gum is in a range equal to or greater than 20/80 and equal to or less than 70/30,

a total of the locust bean gum and the xanthan gum is in an amount of 10 to 30 parts by weight relative to 100 parts by weight of a total of the plant-derived water-insoluble powder and the plant-derived water-soluble polymer, and

the plant-derived water-insoluble powder includes starch.

11. The method according to claim 10 , wherein the shell solution includes no animal-derived material and no carrageenan.

12. The method according to claim 10 , wherein the plant-derived water-soluble polymer includes at least one of a starch decomposition product and polydextrose.

Assignments (5)
CHANGE OF NAME Recorded Apr 25, 2023
From: SUMITOMO PHARMA FOOD & CHEMICAL CO., LTD.
To: MP GOKYO FOOD & CHEMICAL CO., LTD.
Reel/Frame 063440/0229 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE'S ADDRESS PREVIOUSLY RECORDED ON REEL 059820 FRAME 0703. ASSIGNOR(S) HEREBY CONFIRMS THE CHANGE OF NAME. Recorded May 17, 2022
From: DSP GOKYO FOOD & CHEMICAL CO., LTD.
To: SUMITOMO PHARMA FOOD & CHEMICAL CO., LTD.
Reel/Frame 060081/0360 →
CHANGE OF NAME Recorded Apr 28, 2022
From: DSP GOKYO FOOD & CHEMICAL CO., LTD.
To: SUMITOMO PHARMA FOOD & CHEMICAL CO., LTD.
Reel/Frame 059820/0703 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 25, 2020
From: KURIHARA, SHINYA; MIWA, MAKOTO; OKAYAMA, TOMOKAZU; KUBOTA, KEIICHI; KOBAYASHI, TAKANORI
To: SUNSHO PHARMACEUTICAL CO., LTD.
Reel/Frame 053593/0502 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 25, 2020
From: IWATA, REI; YAMANISHI, KENTA
To: DSP GOKYO FOOD & CHEMICAL CO., LTD.
Reel/Frame 053593/0555 →
Priority Claims (1)
JP 2018-034621 · Feb 28, 2018 · national
Continuity (1)
Related Publication 20200405647A1 · Dec 31, 2020
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