Granted Patent
B1
US 10,858,331 · App. 16/987,609 · Granted Dec 8, 2020
Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease
Inventors:
Martin Safo (Richmond, VA); Yan Zhang (Glen Allen, VA); Jurgen Venitz (Richmond, VA); Richmond Danso-Danqua (Henrico, VA); Tanvi Deshpande (Somerville, MA)
Assignee:
Virginia Commonwealth University
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Abstract
The invention provides new aromatic aldehyde compounds that have greater potency in increasing the affinity of Hb for oxygen, greater potency for preventing sickling, and additional pharmacologic properties that ameliorate other symptoms of SCD. The invention further provides methods for treating SCD by providing a subject having SCD with a compound according to the invention.
Claims (4)
1. A compound having the formula:
and pharmaceutically acceptable salts thereof.
2. A compound having the formula:
and pharmaceutically acceptable salts thereof.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Oct 2, 2023
From: VIRGINIA COMMENWEALTH UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 065091/0710 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Feb 18, 2021
From: SAFO, MARTIN; ZHANG, YAN; VENITZ, JURGEN; DANSO-DANQUAH, RICHMOND; DESHPANDE, TANVI
To: VIRGINIA COMMONWEALTH UNIVERSITY
Reel/Frame 055306/0235 →
Continuity (2)
Continuation
14913180
Provisional Application
61869162
· Aug 23, 2013