Method for aromatic fluorination
Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO 2 F 2 to a reaction mixture; reacting the SO 2 F 2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where Ar is an aryl or heteroaryl; providing SO 2 F 2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO 2 F 2 , the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.
1. A fluorination method comprising:
providing a compound having the structure Ar—OH to a reaction mixture;
where Ar is an aryl or heteroaryl;
providing SO 2 F 2 to the reaction mixture;
providing a fluorinating reagent to the reaction mixture;
reacting the SO 2 F 2 , the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.
2. The fluorination method of claim 1 , wherein the fluorinating reagent is selected from the group consisting of sodium fluoride, potassium fluoride, cesium fluoride, tetrabutylammonium fluoride, and tetramethylammonium fluoride.
3. A method according to claim 1 , further comprising providing a solvent to the reaction mixture.
4. The fluorination method of claim 3 , wherein the solvent is selected from the group consisting of polar aprotic solvents, alkoxy ether solvents, nitrile solvents, aromatic solvents, and mixtures thereof.
5. The fluorination method of claim 4 , wherein the solvent comprises a polar aprotic solvent.
6. The fluorination method of claim 4 , wherein the solvent comprises an alkoxy ether solvent.
7. The fluorination method of claim 4 , wherein the solvent comprises a nitrile solvents.
8. The fluorination method of claim 4 , wherein the solvent comprises an aromatic solvent.
9. The fluorination method of claim 3 , wherein the fluorinating reagent is selected from the group consisting of sodium fluoride, potassium fluoride, cesium fluoride, tetrabutylammonium fluoride, and tetramethylammonium fluoride.
10. The fluorination method of claim 4 , wherein the fluorinating reagent is selected from the group consisting of sodium fluoride, potassium fluoride, cesium fluoride, tetrabutylammonium fluoride, and tetramethylammonium fluoride.
11. A method according to claim 1 , wherein Ar—OH is