Immunogenic compositions comprising
The present invention provides combination vaccines that comprise an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis , and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine. Moreover, the present invention also relates to a kit that comprises an immunological agent effective for reducing the incidence of or lessening the severity of PPE caused by L. intracellularis , and one or more immunological active components effective in treatment and/or prophylaxis of at least one further disease-causing organism for swine.
1. A pharmaceutical composition comprising antigens which consist essentially of:
i. killed Lawsonia intracellularis bacterium,
ii. killed Mycoplasma hyopneumoniae.
2. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition further comprises a pharmaceutically acceptable carrier.
3. The pharmaceutical composition of claim 2 , wherein the pharmaceutically acceptable carrier is an adjuvant.
4. The pharmaceutical composition of claim 3 , wherein said adjuvant is a water-in-oil emulsion, oil-in-water emulsion or water-in-oil-in-water emulsion.
5. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition has between 1×10 2 TCID 50 to 1×10 9 TCID 50 of the killed Lawsonia intracellularis bacterium.