IP Library › Granted Patent US 12,251,150
Granted Patent B2
US 12,251,150 · App. 17/099,465 · Granted Mar 18, 2025

Neuromodulation cryotherapeutic devices and associated systems and methods

Inventors: Naomi Buckley (Galway, IE); Benjamin J Clark (Redwood City, CA); Michael Cummins (Roscam, IE); Danny Donovan (Galway, IE); Mark Gelfand (New York, NY); Luke Hughes (Galway, IE); Brian Kelly (Galway, IE); Gary Kelly (Windsor, CA); Grace Kelly (Clifden, IE); John Kelly (Ballinsloe, IE); Mark S. Leung (Shawnigan Lake, CA); Gwenda Francis (Ballybrit, IE); Barry Mullins (County Wicklow, IE); Karun D. Naga (Los Altos, CA); Stephen Nash (Galway, IE); Eric Ryba (Durango, CO); Fiachra Sweeney (Galway, IE); Vincenzo Tilotta (Galway, IE); Roman Turovskiy (San Francisco, CA); Lana Woolley (Galway, IE); Denise Zarins (Saratoga, CA); Michael Turovskiy (East Palo Alto, CA)
Assignee: Medtronic Ardian Luxembourg S.a.r.l.
A61B18/02A61B2017/22054A61B2017/22067A61B2018/00023A61B2018/00166A61B2018/0022A61B2018/00232A61B2018/0025A61B2018/00261A61B2018/00404A61B2018/00434A61B2018/00511A61B2018/00577A61B2018/0212A61B2018/0262A61B2018/0268
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Quick Facts
Patent No.
US 12,251,150
App. No.
17/099,465
Granted
Mar 18, 2025
Kind
B2
Abstract

Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

Claims (57)

1. A cryotherapeutic system, comprising:

a cryotherapeutic device including:

an elongated shaft with a distal end portion that is configured to locate the distal end portion intravascularly at a treatment site within a renal artery or renal ostium,

a cooling assembly positioned at the distal end portion of the elongated shaft and including an applicator with an expandable element, the expandable element including an inner expandable element having orifices, the inner expandable element configured to distribute a refrigerant to the expandable element via the orifices,

wherein the expandable element includes a raised helical portion positioned around a recessed portion with the expandable element in an expanded state,

a pressure sensor configured to detect a pressure within the expandable element,

a pressure line fluidly coupling a pressure monitoring lumen and the pressure sensor, the pressure monitoring lumen extending through the elongated shaft and having a distal opening in fluid communication with the expandable element; and

a console coupled to the cryotherapeutic device and including:

a refrigerant supply container that is configured to retain the refrigerant and is coupled to a supply line that is configured to transport the refrigerant to the cryotherapeutic device,

an adaptor configured to removably couple the pressure line to the console such that the pressure line is removable from the console, and

a controller configured to:

determine whether the pressure sensor is calibrated; and

control a flow of the refrigerant to the cryotherapeutic device based on the pressure in response to determining that the pressure sensor is calibrated.

2. The cryotherapeutic system of claim 1 , wherein the console includes:

a supply control valve that is in fluid communication with the refrigerant supply container and is coupled to the supply line and is configured to regulate the flow of the refrigerant through the cryotherapeutic device.

3. The cryotherapeutic system of claim 2 , wherein to control the flow of the refrigerant the controller is configured to partially close the supply control valve to decrease or terminate the flow of the refrigerant when the pressure is above a predetermined threshold.

4. The cryotherapeutic system of claim 1 , wherein the console includes:

at least one of a pump or a backpressure control valve that is coupled to an exhaust line that is configured to receive evaporated refrigerant from the cryotherapeutic device.

5. The cryotherapeutic system of claim 4 , wherein to control the flow of the refrigerant the controller is configured to control an amount of vacuum applied to the refrigerant returning from the cryotherapeutic device using the at least one of the pump or the backpressure control valve to decrease backpressure in the exhaust line and increase the flow of the refrigerant from the cryotherapeutic device when the pressure is above a predetermined threshold.

6. The cryotherapeutic system of claim 1 , wherein the cryotherapeutic device includes:

a supply lumen coupled to the supply line and configured to receive the refrigerant from the refrigerant supply container, wherein the refrigerant passes through the supply lumen to inflate the expandable element.

7. The cryotherapeutic system of claim 6 , wherein the cryotherapeutic device includes:

an exhaust lumen coupled to an exhaust line and is configured to pass the refrigerant to the exhaust line that is configured to receive the refrigerant.

8. The cryotherapeutic system of claim 1 , wherein the controller is configured to:

compare the pressure detected by the pressure sensor with an ambient pressure as the cryotherapeutic system powers on; and

determine whether the pressure sensor is calibrated based on the comparison.

9. A cryotherapeutic system, comprising:

a cryotherapeutic device including:

an elongated shaft with a distal end portion that is configured to locate the distal end portion intravascularly at a treatment site within a renal artery or renal ostium,

a cooling assembly including an applicator with an expandable element, the expandable element including an inner expandable element having orifices, the inner expandable element configured to distribute a refrigerant to the expandable element via the orifices,

wherein the expandable element includes a raised helical portion positioned around a recessed portion with the expandable element in an expanded state,

a pressure sensor configured to detect a pressure within the expandable element, and

a pressure line fluidly coupling a pressure monitoring lumen and the pressure sensor, the pressure monitoring lumen extending through the elongated shaft and having a distal opening in fluid communication with the expandable element; and

a console coupled to the cryotherapeutic device and including:

a refrigerant supply container that is configured to retain the refrigerant and is coupled to a supply line that is configured to transport the refrigerant to the cryotherapeutic device,

an adaptor configured to removably couple the pressure line to the console such that the pressure line is removable from the console,

at least one of a supply control valve or a backpressure control valve to control a flow of the refrigerant to the cryotherapeutic device based on the pressure, and

a controller configured to:

determine whether the pressure sensor is calibrated; and

control the at least one of the supply control valve or the backpressure control valve in response to determining that the pressure sensor is calibrated.

10. The cryotherapeutic system of claim 9 , wherein the at least one of the supply control valve or the backpressure control valve includes the supply control valve, wherein the supply control valve is in fluid communication with the refrigerant supply container and is coupled to the supply line.

11. The cryotherapeutic system of claim 10 , wherein the supply control valve is configured to partially close to decrease or terminate the flow of the refrigerant when the pressure is above a predetermined threshold.

12. The cryotherapeutic system of claim 9 , wherein the at least one of the supply control valve or the backpressure control valve includes the backpressure control valve, wherein the backpressure control valve is coupled to an exhaust line that is configured to receive evaporated refrigerant from the cryotherapeutic device.

13. The cryotherapeutic system of claim 9 , wherein the cryotherapeutic devices includes:

a supply lumen coupled to the supply line and configured to receive the refrigerant from the refrigerant supply container, wherein the refrigerant passes through the supply lumen to inflate the expandable element.

14. The cryotherapeutic system of claim 9 , wherein the pressure sensor is coupled directly to the least one of a supply control valve or the backpressure control valve to automatically regulate the flow of the refrigerant in response to the pressure.

15. A cryotherapeutic device, comprising:

an elongated shaft with a distal end portion that is configured to locate the distal end portion intravascularly at a treatment site within a renal artery or renal ostium;

a cooling assembly positioned at the distal end portion and including an applicator with an expandable element,

wherein the expandable element includes an inner expandable element having orifices, the inner expandable element configured to distribute a refrigerant to the expandable element via the orifices,

wherein the expandable element includes a raised helical portion positioned around a recessed portion with the expandable element in an expanded state; and

a pressure sensor configured to detect a pressure within the expandable element.

16. The cryotherapeutic device of claim 15 , further comprising:

a supply lumen coupled to a supply line and configured to receive refrigerant from a refrigerant supply container, wherein the refrigerant passes through the supply lumen to inflate the expandable element.

17. The cryotherapeutic device of claim 16 , further comprising:

an exhaust lumen coupled to an exhaust line and is configured to pass the refrigerant to the exhaust line that is configured to receive the refrigerant.

18. The cryotherapeutic device of claim 15 , wherein the pressure sensor is configured to indicate when the pressure is above a predetermined threshold within a range of a burst pressure of the expandable element.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 19, 2021
From: BUCKLEY, NAOMI; CLARK, BENJAMIN J.; CUMMINS, MICHAEL; DONOVAN, DANNY; HUGHES, LUKE; KELLY, BRIAN; KELLY, GARY; KELLY, GRACE; KELLY, JOHN; MCMULLIN, GWENDA; NAGA, KARUN D.; NASH, STEPHEN; RYBA, ERIC; SWEENEY, FIACHRA; TILOTTA, VINCENZO; TUROVSKIY, ROMAN; WOOLLEY, LANA; ZARINS, DENISE; GELFAND, MARK; LEUNG, MARK S.; MULLINS, BARRY; TUROVSKIY, MICHAEL
To: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.
Reel/Frame 056920/0563 →
Continuity (8)
Continuation 16221174 · Dec 14, 2018
Continuation 15229761 · Aug 5, 2016
Continuation 13279326 · Oct 23, 2011
Provisional Application 61546510 · Oct 12, 2011
Provisional Application 61528684 · Aug 29, 2011
Provisional Application 61528091 · Aug 26, 2011
Provisional Application 61406968 · Oct 26, 2010
Related Publication 20210068886A1 · Mar 11, 2021
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