IP Library Granted Patent US 11,723,902
Granted Patent B2
US 11,723,902 · App. 17/119,482 · Granted Aug 15, 2023

Medical treatments based on anamorelin

Inventors: William Mann (Hoboken, NJ); John Friend (Colts Neck, NJ); William Polvino (Tinton Falls, NJ); Suzan Allen (Georgetown, TX); Ming Lu (Plainsboro, NJ); Elizabeth Duus (Cape Coral, FL); Ruben Giorgino (Allschwil, CH); Enrico Baroni (Cernobbio, IT)
Assignee: Helsinn Healthcare SA
A61K31/454A61K31/00
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Quick Facts
Patent No.
US 11,723,902
App. No.
17/119,482
Granted
Aug 15, 2023
Kind
B2
Abstract

Methods of treating cancer related conditions using anamorelin are described.

Claims (12)

1. A method of treating cachexia in a human patient having a body mass index less than 20 kg/m 2 , comprising administering to the patient a therapeutically effective amount of anamorelin once daily for a therapeutically effective period of time.

2. A method of treating cachexia in a human patient having a body mass index less than 20 kg//m 2 , comprising administering to the patient a therapeutically effective amount of anamorelin once daily for a therapeutically effective period of time and increasing total body mass of the patient.

3. A method of treating cachexia in a human patient having a body mass index less than 20 kg/m 2 , comprising administering to the patient a therapeutically effective amount of anamorelin on a daily basis for a therapeutically effective period of time and improving quality of life in the patient as measured by FAACT in the anorexia/cachexia domain.

4. A method of treating cachexia in a human patient having a body mass index less than 20 kg/m 2 , comprising administering to the patient a therapeutically effective amount of anamorelin once daily for a therapeutically effective period of time, increasing total body mass of the patient, and improving quality of life in the patient as measured by a subset of symptoms questions on FAACT in the anorexia/cachexia domain.

5. The method of claim 1 , wherein the patient has a body weight loss greater than or equal to 2% in the previous 6 months.

6. The method of claim 1 , further comprising increasing total body mass of the patient.

7. The method of claim 1 , further comprising improving quality of life in the patient as measured by FAACT in the anorexia/cachexia domain.

8. The method of claim 1 , further comprising increasing total body mass of the patient and improving quality of life in the patient as measured by FAACT in the anorexia/cachexia domain.

9. The method of claim 2 , wherein the patient has a body weight loss greater than or equal to 2% in the previous 6 months.

10. The method of claim 2 , further comprising improving quality of life in the patient as measured by FAACT in the anorexia/cachexia domain.

11. The method of claim 3 , wherein the patient has a body weight loss greater than or equal to 2% in the previous 6 months.

12. The method of claim 4 , wherein the patient has a body weight loss greater than or equal to 2% in the previous 6 months.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 30, 2024
From: MANN, WILLIAM; FRIEND, JOHN; LU, MING; DUUS, ELIZABETH; POLVINO, WILLIAM; ALLEN, SUZAN; GIORGINO, RUBEN; BARONI, ENRICO
To: HELSINN HEALTHCARE SA
Reel/Frame 067575/0435 →
RELEASE OF SECURITY INTEREST Recorded Sep 20, 2023
From: HAMILTON SA LLC
To: HELSINN HEALTHCARE SA; HELSINN THERAPEUTICS (U.S.), INC.; HELSINN BIREX PHARMACEUTICALS LIMITED
Reel/Frame 064961/0567 →
SECURITY INTEREST Recorded Dec 30, 2022
From: HELSINN HEALTHCARE SA; HELSINN THERAPEUTICS (U.S.), INC.; HELSINN BIREX PHARMACEUTICALS LIMITED
To: HAMILTON SA LLC
Reel/Frame 062254/0888 →
Continuity (5)
Continuation 16275669 · Feb 14, 2019
Continuation 15590025 · May 9, 2017
Continuation 14839038 · Aug 28, 2015
Provisional Application 62045976 · Sep 4, 2014
Related Publication 20210093627A1 · Apr 1, 2021