IP Library Granted Patent US 12,376,802
Granted Patent B2
US 12,376,802 · App. 17/127,266 · Granted Aug 5, 2025

System and method for health monitoring including a user device and biosensor

Inventor: Robert Steven Newberry (New Hope, AL)
A61B5/7278A61B5/0022A61B5/01A61B5/0205A61B5/02416A61B5/1118A61B5/14532A61B5/14546A61B5/1455A61B5/14551A61B5/14552A61B5/4839A61B5/4845A61B5/6817A61B5/7275A61B5/742A61B5/743A61M5/14248A61M5/1723G16H40/63G16H40/67A61B5/0008A61B5/6826A61B2560/0223A61M2205/3303A61M2205/3313A61M2205/3368A61M2205/3553A61M2205/3584A61M2205/505A61M2230/06
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,376,802
App. No.
17/127,266
Granted
Aug 5, 2025
Kind
B2
Abstract

A biosensor unit is coupled to a user device and may communicate with the user device over a short range wireless or wired interface. The biosensor unit includes an optical sensor used to obtain a plurality of PPG signals. The PPG signals are used to obtain an oxygen saturation level, a heart rate and a respiration rate of a user. The PPG signal may also be used to obtain a nitric oxide (NO) level and glucose level of the user. The user device may generate a graphical user interface to display the biosensor data to a user.

Claims (57)

1. User equipment, comprising:

a display;

at least one transceiver configured to communicate with an external biosensor, wherein the at least one transceiver receives biosensor data from the biosensor, wherein the biosensor data includes a first photoplethysmography (PPG) signal at a first wavelength of light and a second PPG signal at a second wavelength of light;

at least one processing circuit and at least one memory device, wherein the at least one memory device stores instructions which when executed by the at least one processing device, causes the user equipment to:

process the biosensor data to determine a relative alternating current (AC) component and a direct current (DC) component of the first wavelength of light and the second wavelength of light;

determine a level of nitric oxide (NO) in blood flow based on the relative AC component and the DC component of the first wavelength of light and the second wavelength of light; and

generate a graphical user interface (GUI) that displays the biosensor data on the display of the user equipment.

2. The user equipment of claim 1 , wherein the user equipment is further configured to:

generate a GUI that displays one or more commands for controlling the biosensor;

receive user input indicating a command for the biosensor; and

transmit a command to the biosensor in response to the user input.

3. The user equipment of claim 1 , wherein the first wavelength of light has a high absorption coefficient for nitric oxide (NO) levels in blood flow and the second wavelength of light has a low absorption coefficient for NO levels in blood flow.

4. The user equipment of claim 3 , wherein the user equipment is further configured to:

obtain a first wavelength value (L λ1 ) using the first PPG signal;

obtain a second wavelength value (L λ2 ) using the second PPG signal; and

determine a ratio value (R λ1, λ2 ) using a ratio including the value La and the value L λ2 .

5. The user equipment of claim 4 , wherein the user equipment is further configured to:

determine a level of nitric oxide (NO) in blood flow using at least the value R λ1, λ2 .

6. The user equipment of claim 4 , wherein the user equipment is further configured to:

obtain a blood glucose concentration level using at least the value R λ1, λ2 and a calibration.

7. The user equipment of claim 1 , wherein the user equipment is further configured to:

determine a level of one or more additional substances in blood flow using the biosensor data.

8. The user equipment of claim 1 , wherein the user equipment is further configured to:

determine a level of vasodilation using the biosensor data, wherein the level of vasodilation includes a measurement of a localized change in width of a vessel from a localized relaxation of vascular muscle cells within the vessel walls.

9. The user equipment of claim 1 , wherein the biosensor is implemented in a finger attachment and the user equipment includes a smart phone.

10. User equipment, comprising:

a display;

at least one transceiver configured to communicate over a cellular network and to an external biosensor; and

at least one processing circuit and at least one memory device, wherein the at least one memory device stores instructions which when executed by the at least one processing device, causes the user equipment to:

obtain a first wavelength value (L λ1 ) using an alternating current (AC) component and a direct current (DC) component of a first photoplethysmography (PPG) signal;

obtain a second wavelength value (L λ2 ) using an AC component and a DC component of a second PPG signal;

obtain a ratio value (R λ1, λ2 ) from a ratio including the value La and the value L λ2 ;

obtain a blood glucose level using the value R λ1, λ2 ; and

generate a graphical user interface that includes the blood glucose level on the display.

11. The user equipment of claim 10 , wherein the first PPG signal is obtained at a first wavelength with the high absorption coefficient for nitric oxide (NO) levels in blood flow and the second PPG signal is obtained at a second wavelength with a low absorption coefficient for NO levels in blood flow.

12. The user equipment of claim 10 , wherein the user equipment is further configured to:

generate a command to a drug administrative device to administer medication.

13. The user equipment of claim 10 , wherein the user equipment is configured to:

generate a message with the blood glucose level to a third party health care provider; and

transmit the message over a wide area network to the third party health care provider.

14. The user equipment of claim 10 , wherein the user equipment is further configured to:

determine a level of one or more additional substances in blood flow using the biosensor data.

15. The user equipment of claim 10 , wherein the user equipment is further configured to:

determine a level of vasodilation using the biosensor data, wherein the level of vasodilation includes a measurement of a localized change in width of a vessel from a localized relaxation of vascular muscle cells within the vessel walls.

16. The user equipment of claim 10 , wherein the biosensor is implemented in a finger attachment and the user equipment includes a smart phone.

17. User equipment, comprising:

one or more transceivers configured to communicate over a cellular network and to at least one external biosensor;

at least one processing circuit and at least one memory device, wherein the at least one memory device stores instructions which when executed by the at least one processing device, causes the user equipment to:

obtain a first AC component and a first direct current (DC) component of a first photoplethysmography (PPG) signal around a first wavelength of light ( 21 ), wherein the first wavelength of light is in a range of 370 nm to 410 nm;

obtain a second AC component and a second direct current (DC) component of a second PPG signal around a second wavelength of light ( 21 ), wherein the second wavelength of light is in an infrared (IR) range; and

obtain a ratio value (R) from a ratio including the first AC component, the first DC component, the second AC component, and the second DC component.

18. The user equipment of claim 17 , wherein the user equipment is further configured to:

obtain an NO level using the value R λ1, λ2 and a calibration.

19. The user equipment of claim 17 , wherein the user equipment is further configured to:

obtain an blood glucose level using the value R λ1, λ2 and a calibration.

20. The user equipment of claim 17 , wherein the user equipment is further configured to:

determine a level of vasodilation using the biosensor data, wherein the level of vasodilation includes a measurement of a localized change in width of a vessel from a localized relaxation of vascular muscle cells within the vessel walls.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 26, 2021
From: SANMINA CORPORATION
To: TRILINEAR BIOVENTURES, LLC
Reel/Frame 056364/0506 →
SECURITY INTEREST Recorded May 11, 2021
From: TRILINEAR BIOVENTURES, LLC
To: SANMINA CORPORATION
Reel/Frame 056205/0739 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2021
From: NEWBERRY, ROBERT STEVEN
To: SANMINA CORPORATION
Reel/Frame 054981/0108 →
Continuity (12)
Continuation In Part 15718721 · Sep 28, 2017
Continuation In Part 15680991 · Aug 18, 2017
Continuation 15622941 · Jun 14, 2017
Continuation In Part 15462700 · Mar 17, 2017
Continuation In Part 15404117 · Jan 11, 2017
Continuation 15400916 · Jan 6, 2017
Continuation 15276760 · Sep 26, 2016
Continuation 15275444 · Sep 25, 2016
Continuation 15275388 · Sep 24, 2016
Continuation 14866500 · Sep 25, 2015
Provisional Application 62457138 · Feb 9, 2017
Related Publication 20210137466A1 · May 13, 2021
References Cited (221)
US 4913150A · Cheung et al. · 1990 [cited by applicant]
US 5115133A · Knudson · 1992 [cited by applicant]
US 5269310A · Jones et al. · 1993 [cited by applicant]
US 5358703A · Lai · 1994 [cited by applicant]
US 5515847A · Braig et al. · 1996 [cited by applicant]
US 5673692A · Schulze et al. · 1997 [cited by applicant]
US 5823966A · Buchert · 1998 [cited by applicant]
US 5947911A · Wong et al. · 1999 [cited by applicant]
US 5983121A · Tsuchiya · 1999 [cited by applicant]
US 6087087A · Yonetani et al. · 2000 [cited by applicant]
US 6280390B1 · Akselrod et al. · 2001 [cited by applicant]
US 6285896B1 · Tobler et al. · 2001 [cited by applicant]
US 6305804B1 · Rice et al. · 2001 [cited by applicant]
US 6537225B1 · Mills · 2003 [cited by applicant]
US 6694180B1 · Boesen · 2004 [cited by applicant]
US 6719705B2 · Mills · 2004 [cited by applicant]
US 6819950B2 · Mills · 2004 [cited by applicant]
US 6921367B2 · Mills · 2005 [cited by applicant]
US 6985763B2 · Boas et al. · 2006 [cited by applicant]
US 7154592B2 · Reynolds et al. · 2006 [cited by applicant]
US 7167736B2 · Winther · 2007 [cited by applicant]
US 7171251B2 · Sarussi et al. · 2007 [cited by applicant]
US 7179228B2 · Banet · 2007 [cited by applicant]
US 7209775B2 · Bae et al. · 2007 [cited by applicant]
US 7291497B2 · Holmes et al. · 2007 [cited by applicant]
US 7371562B2 · Cunningham et al. · 2008 [cited by applicant]
US 7608045B2 · Mills · 2009 [cited by applicant]
US 7647083B2 · Al-Ali et al. · 2010 [cited by applicant]
US 7761127B2 · Al-Ali et al. · 2010 [cited by applicant]
US 7763472B2 · Doctor et al. · 2010 [cited by applicant]
US 7764982B2 · Dalke et al. · 2010 [cited by applicant]
US 7941199B2 · Kiani · 2011 [cited by applicant]
US 8224411B2 · Al-Ali et al. · 2012 [cited by applicant]
US 8255027B2 · Al-Ali et al. · 2012 [cited by applicant]
US 8328420B2 · Abreu · 2012 [cited by applicant]
US 8385996B2 · Smith et al. · 2013 [cited by applicant]
US 8401605B2 · Huiku · 2013 [cited by applicant]
US 8483787B2 · Al-Ali et al. · 2013 [cited by applicant]
US 8494507B1 · Tedesco et al. · 2013 [cited by applicant]
US 8597274B2 · Sloan et al. · 2013 [cited by applicant]
US 8652040B2 · Leboeuf et al. · 2014 [cited by applicant]
US 8676284B2 · He · 2014 [cited by applicant]
US 8730047B2 · Ridder et al. · 2014 [cited by applicant]
US 8868149B2 · Eisen et al. · 2014 [cited by applicant]
US 8888701B2 · Leboeuf et al. · 2014 [cited by applicant]
US 8906693B2 · Schultz et al. · 2014 [cited by applicant]
US 8923918B2 · Kreger et al. · 2014 [cited by applicant]
US 8961932B2 · Silverman · 2015 [cited by applicant]
US 9022973B2 · Sexton et al. · 2015 [cited by applicant]
US 9131882B2 · Al-Ali et al. · 2015 [cited by applicant]
US 9149216B1 · Eisen et al. · 2015 [cited by applicant]
US 9149646B2 · Keswarpu et al. · 2015 [cited by applicant]
US 9387033B2 · Yodfat et al. · 2016 [cited by applicant]
US 9442092B2 · Lane · 2016 [cited by applicant]
US 9521970B2 · Hoppe et al. · 2016 [cited by applicant]
US 9554738B1 · Gulati et al. · 2017 [cited by applicant]
US 9642578B2 · Newberry · 2017 [cited by applicant]
US 9668701B2 · Maarek · 2017 [cited by applicant]
US 9713428B2 · Chon et al. · 2017 [cited by applicant]
US 9739663B2 · Halder et al. · 2017 [cited by applicant]
US 9820656B2 · Olivier · 2017 [cited by applicant]
US 9839381B1 · Weber et al. · 2017 [cited by applicant]
US 9924895B2 · Rawicz et al. · 2018 [cited by applicant]
US 9949675B2 · Miller · 2018 [cited by applicant]
US 9999355B2 · Kirenko · 2018 [cited by applicant]
US 10028682B2 · Thiele · 2018 [cited by applicant]
US D824937S · Sparandara et al. · 2018 [cited by applicant]
US 10099554B2 · Steeg et al. · 2018 [cited by applicant]
US 10130285B1 · Singamsetty et al. · 2018 [cited by applicant]
US 10153796B2 · Fung et al. · 2018 [cited by applicant]
US 10181021B2 · Venkatraman et al. · 2019 [cited by applicant]
US 10206619B1 · Lee et al. · 2019 [cited by applicant]
US 10215698B2 · Han et al. · 2019 [cited by applicant]
US 10227063B2 · Abreu · 2019 [cited by applicant]
US 10232156B2 · Netzel et al. · 2019 [cited by applicant]
US 10278591B2 · Gil · 2019 [cited by applicant]
US D850316S · Ennis et al. · 2019 [cited by applicant]
US 10314500B2 · Olivier · 2019 [cited by applicant]
US 10322728B1 · Porikli et al. · 2019 [cited by applicant]
US 10342495B2 · Melkoniemi et al. · 2019 [cited by applicant]
US 10349847B2 · Kwon et al. · 2019 [cited by applicant]
US 10420470B2 · Kwon et al. · 2019 [cited by applicant]
US 10420491B2 · Rajan et al. · 2019 [cited by applicant]
US 10433726B2 · Ramesh et al. · 2019 [cited by applicant]
US 10433738B2 · Thomas et al. · 2019 [cited by applicant]
US 10433739B2 · Weekly et al. · 2019 [cited by applicant]
US 10463283B2 · Ferber et al. · 2019 [cited by applicant]
US 20020049389A1 · Abreu · 2002 [cited by applicant]
US 20030229276A1 · Sarussi et al. · 2003 [cited by applicant]
US 20040078219A1 · Kaylor et al. · 2004 [cited by applicant]
US 20040100376A1 · Lye et al. · 2004 [cited by applicant]
US 20040157341A1 · Reynolds et al. · 2004 [cited by applicant]
US 20050101841A9 · Kaylor et al. · 2005 [cited by applicant]
US 20050209516A1 · Fraden · 2005 [cited by applicant]
US 20050228244A1 · Banet · 2005 [cited by applicant]
US 20050228299A1 · Banet · 2005 [cited by applicant]
US 20050245831A1 · Banet · 2005 [cited by applicant]
US 20060009698A1 · Banet · 2006 [cited by applicant]
US 20060094942A1 · Winther · 2006 [cited by applicant]
US 20060287589A1 · Wobermin et al. · 2006 [cited by applicant]
US 20070202605A1 · Doctor et al. · 2007 [cited by applicant]
US 20070203405A1 · Shimomura · 2007 [cited by applicant]
US 20070260132A1 · Sterling · 2007 [cited by applicant]
US 20080146890A1 · Leboeuf et al. · 2008 [cited by applicant]
US 20080165017A1 · Schwartz · 2008 [cited by applicant]
US 20080208019A1 · Nitzan · 2008 [cited by applicant]
US 20080241199A1 · Silverman · 2008 [cited by applicant]
US 20090043178A1 · Belotserkovsky · 2009 [cited by applicant]
US 20090156988A1 · Ferren et al. · 2009 [cited by applicant]
US 20090187167A1 · Sexton et al. · 2009 [cited by applicant]
US 20090287120A1 · Ferren et al. · 2009 [cited by applicant]
US 20100049020A1 · Dalke et al. · 2010 [cited by applicant]
US 20100191080A1 · Mills · 2010 [cited by applicant]
US 20100274101A1 · Lin et al. · 2010 [cited by applicant]
US 20100295686A1 · Sloan et al. · 2010 [cited by applicant]
US 20100331631A1 · MacLaughlin · 2010 [cited by applicant]
US 20110082355A1 · Eisen et al. · 2011 [cited by applicant]
US 20110106050A1 · Yodfat et al. · 2011 [cited by applicant]
US 20110137141A1 · Razoumov et al. · 2011 [cited by applicant]
US 20110160697A1 · Yodfat et al. · 2011 [cited by applicant]
US 20110166553A1 · Holmes et al. · 2011 [cited by applicant]
US 20110224518A1 · Tindi et al. · 2011 [cited by applicant]
US 20110237464A1 · Cunningham et al. · 2011 [cited by applicant]
US 20110275978A1 · Hyde et al. · 2011 [cited by applicant]
US 20120010683A1 · Keswarpu et al. · 2012 [cited by applicant]
US 20120029363A1 · Lund · 2012 [cited by applicant]
US 20120095302A1 · Adhikari · 2012 [cited by applicant]
US 20120131507A1 · Sparandara et al. · 2012 [cited by applicant]
US 20120136054A1 · Schultz et al. · 2012 [cited by applicant]
US 20120156933A1 · Kreger et al. · 2012 [cited by applicant]
US 20120197093A1 · Lebouef et al. · 2012 [cited by applicant]
US 20120203077A1 · He et al. · 2012 [cited by applicant]
US 20120238844A1 · Grata et al. · 2012 [cited by applicant]
US 20120330126A1 · Hoppe et al. · 2012 [cited by applicant]
US 20130030259A1 · Thomsen et al. · 2013 [cited by applicant]
US 20130060098A1 · Thomsen et al. · 2013 [cited by applicant]
US 20130066176A1 · Addison et al. · 2013 [cited by applicant]
US 20130110311A1 · Ver Steeg et al. · 2013 [cited by applicant]
US 20130310669A1 · Nitzan · 2013 [cited by applicant]
US 20140046160A1 · Terashima et al. · 2014 [cited by applicant]
US 20140100432A1 · Golda et al. · 2014 [cited by applicant]
US 20140112940A1 · Lane · 2014 [cited by applicant]
US 20140194342A1 · Zhang et al. · 2014 [cited by applicant]
US 20140243648A1 · Dubielczyk · 2014 [cited by applicant]
US 20140253709A1 · Bresch et al. · 2014 [cited by applicant]
US 20140275852A1 · Hong et al. · 2014 [cited by applicant]
US 20140297313A1 · Condurso et al. · 2014 [cited by applicant]
US 20140316226A1 · Ferber et al. · 2014 [cited by applicant]
US 20150066238A1 · Todd et al. · 2015 [cited by applicant]
US 20150088007A1 · Bardy et al. · 2015 [cited by applicant]
US 20150094914A1 · Abreu · 2015 [cited by applicant]
US 20150105638A1 · Eisen et al. · 2015 [cited by applicant]
US 20150109617A1 · Gilbert et al. · 2015 [cited by applicant]
US 20150148622A1 · Moyer et al. · 2015 [cited by applicant]
US 20150148635A1 · Benaron · 2015 [cited by applicant]
US 20150150453A1 · Abreu · 2015 [cited by applicant]
US 20150182172A1 · Shelley et al. · 2015 [cited by applicant]
US 20150229341A1 · Fung et al. · 2015 [cited by applicant]
US 20150250404A1 · Maarek · 2015 [cited by applicant]
US 20150282747A1 · Thiele · 2015 [cited by applicant]
US 20150366471A1 · Leboeuf et al. · 2015 [cited by applicant]
US 20160018257A1 · Mirov et al. · 2016 [cited by applicant]
US 20160058308A1 · Robinson · 2016 [cited by applicant]
US 20160058347A1 · Reichgott et al. · 2016 [cited by applicant]
US 20160066863A1 · Thaveeprungsrporn et al. · 2016 [cited by applicant]
US 20160100781A1 · Bechtel et al. · 2016 [cited by applicant]
US 20160262707A1 · Devries · 2016 [cited by applicant]
US 20160345912A1 · Maarek · 2016 [cited by applicant]
US 20160367154A1 · Gladshtein et al. · 2016 [cited by applicant]
US 20170027521A1 · Geva et al. · 2017 [cited by applicant]
US 20170050518A1 · Steeg et al. · 2017 [cited by applicant]
US 20170071550A1 · Newberry · 2017 [cited by applicant]
US 20170091436A1 · Cao et al. · 2017 [cited by applicant]
US 20170172477A1 · Adusumilli et al. · 2017 [cited by applicant]
US 20170215811A1 · Newberry · 2017 [cited by applicant]
US 20170256110A1 · Divincent et al. · 2017 [cited by applicant]
US 20170347894A1 · Bhushan et al. · 2017 [cited by applicant]
US 20170347899A1 · Bhushan et al. · 2017 [cited by applicant]
US 20180117291A1 · Netzel et al. · 2018 [cited by applicant]
US 20180140210A1 · Jelfs et al. · 2018 [cited by applicant]
US 20180140237A1 · Rajan et al. · 2018 [cited by applicant]
US 20180177416A1 · Church et al. · 2018 [cited by applicant]
US 20180177440A1 · Jelfs et al. · 2018 [cited by applicant]
US 20180200433A1 · Cirit · 2018 [cited by applicant]
US 20180264242A1 · Hoffman et al. · 2018 [cited by applicant]
US 20180353137A1 · Balajadia et al. · 2018 [cited by applicant]
US 20180358119A1 · Bhushan et al. · 2018 [cited by applicant]
US 20190046039A1 · Ramesh et al. · 2019 [cited by applicant]
US 20190050622A1 · Cabibihan et al. · 2019 [cited by applicant]
US 20190086331A1 · Han · 2019 [cited by applicant]
US 20190099114A1 · Mouradian et al. · 2019 [cited by applicant]
US 20190110745A1 · Linnes et al. · 2019 [cited by applicant]
US 20190125963A1 · Mou et al. · 2019 [cited by applicant]
US 20190125964A1 · Mou et al. · 2019 [cited by applicant]
US 20190133471A1 · Olson et al. · 2019 [cited by applicant]
US 20190192085A1 · Krishna et al. · 2019 [cited by applicant]
US 20190192086A1 · Krishna et al. · 2019 [cited by applicant]
US 20190251238A1 · Venkatraman et al. · 2019 [cited by applicant]
US 20190358387A1 · Elbadry et al. · 2019 [cited by applicant]
CN 102609627A · 2012 [cited by applicant]
EP 2017001250A1 · 2017 [cited by applicant]
EP 3488776A1 · 2019 [cited by applicant]
WO 2004047630A1 · 2004 [cited by applicant]
WO 2007013054A1 · 2007 [cited by applicant]
WO 2008006150A1 · 2008 [cited by applicant]
WO 2010128852A3 · 2010 [cited by applicant]
WO 2010147968A1 · 2010 [cited by applicant]
WO 2012108895A1 · 2012 [cited by applicant]
WO 2013052318A1 · 2013 [cited by applicant]
WO 2013127564A1 · 2013 [cited by applicant]
WO 2014163583A1 · 2014 [cited by applicant]
WO 2015143197A1 · 2015 [cited by applicant]
WO 2015200148A1 · 2015 [cited by applicant]
WO 2017001249A1 · 2017 [cited by applicant]
WO 2018025257A1 · 2018 [cited by applicant]
WO 2018206875A1 · 2018 [cited by applicant]
WO 2019030700A1 · 2019 [cited by applicant]
WO 2019118053A1 · 2019 [cited by applicant]
Alonso et al. “The nitric oxide-endothelin-1 connection.” Heart Failure Review, 8, 107-115 (2003). [cited by applicant]
Noack et al. “Spectrophotometric determination of nitric oxide using hemoglobin.” Neuroprotocols: A Companion to Methods in Neurosciences, vol. 1, No. 2,. pp. 133-139 (Oct. 1992). [cited by applicant]
Ignarro et al. “Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.” Proc. Natl. Acad. Sci. USA vol. 84, pp. 9265, 9269 (Dec. 1987). [cited by applicant]