Granted Patent B2

US 12,508,076 · App. 17/148,181 · Granted Dec 30, 2025

Inventors: Christopher A. Cook (Laguna Niguel, CA); Gerald D. Bacher (Carlsbad, CA); Eric Schultheis (San Clemente, CA); Mina Mossayebi (Irvine, CA); Wenjie Xie (La Crescenta, CA); Yu Liu (Irvine, CA)

Assignee: Bolt Medical, Inc.

A61B18/245G02B6/4214G02B27/283A61B2018/0022

Abstract

Claims (65)

1 . A method for treating a treatment site within or adjacent to a vessel wall within a body of a patient by generating a plasma that creates pressure waves adjacent to the treatment site, the method comprising the steps of:

coupling a balloon to a catheter shaft, the balloon including a balloon wall that defines a balloon interior;

positioning a first light guide and a second light guide at least partially within the balloon interior;

selectively inflating the balloon with a balloon fluid to expand to an inflated state;

positioning the balloon wall adjacent to the treatment site when the balloon is in the inflated state;

generating light energy in the form of a source beam with a single light source;

positioning a multiplexer in a beam path of the source beam, the multiplexer including (i) a multiplexer base that is fixed in position relative to the first light guide and the second light guide, (ii) a multiplexer stage that is movably supported on the multiplexer base, (iii) a stage mover that is configured to move the multiplexer stage in a single linear degree of freedom relative to the multiplexer base, (iv) a redirector that is mounted on the multiplexer stage, and (v) coupling optics that are mounted on the multiplexer stage, movement of the multiplexer stage relative to the multiplexer base resulting in corresponding movement of the redirector and the coupling optics relative to the first light guide and the second light guide;

controlling operation of the light source with a system controller including a processor to generate a single source beam in the form of pulses of light energy that are directed to the multiplexer;

receiving the pulses of light energy with the multiplexer, the pulses of light energy being received with the multiplexer initially impinging on the redirector, and the redirector redirecting the source beam toward the coupling optics;

controlling operation of the multiplexer with the system controller so that the pulses of light energy that are received by the multiplexer alternatively generate a first guide beam and a second guide beam;

focusing the first guide beam onto the first light guide with the coupling optics;

focusing the second guide beam onto the second light guide with the coupling optics;

receiving the first guide beam with the first light guide, and guiding the first guide beam with the first light guide into the balloon interior to generate a first plasma bubble in the balloon fluid within the balloon interior, the generation of the first plasma bubble imparting pressure waves upon the balloon wall adjacent to the treatment site; and

receiving the second guide beam with the second light guide, and guiding the second guide beam with the second light guide into the balloon interior to generate a second plasma bubble in the balloon fluid within the balloon interior, the generation of the second plasma bubble imparting pressure waves upon the balloon wall adjacent to the treatment site.

2 . A method for treating a vascular lesion within or adjacent to a vessel wall within a body of a patient by generating a plasma that creates pressure waves adjacent to the vascular lesion, the method comprising the steps of:

generating light energy in the form of a source beam with a single light source;

positioning a multiplexer in a beam path of the source beam, the multiplexer including an optical element;

receiving the source beam with the optical element of the multiplexer;

splitting the source beam into a first guide beam and a second guide beam with the optical element of the multiplexer;

directing the first guide beam to a first light guide with the multiplexer; and

directing the second guide beam to a second light guide with the multiplexer;

wherein the step of splitting includes the optical element including an input surface that is partially reflective, a rear surface, and an exit surface that is anti-reflective; and further includes the source beam impinging on the input surface splitting the source beam into the first guide beam that is directed toward coupling optics, and the second guide beam that is transmitted through the input surface toward the rear surface, reflects off of the rear surface and is directed through the exit surface and toward the coupling optics.

3 . A method for treating a vascular lesion within or adjacent to a vessel wall within a body of a patient by generating a plasma that creates pressure waves adjacent to the vascular lesion, the method comprising the steps of:

generating light energy in the form of a source beam with a single light source;

positioning a multiplexer in a beam path of the source beam, the multiplexer including an optical element;

receiving the source beam with the optical element of the multiplexer;

splitting the source beam into a first guide beam and a second guide beam with the optical element of the multiplexer;

directing the first guide beam to a first light guide with the multiplexer; and

directing the second guide beam to a second light guide with the multiplexer;

wherein the step of splitting includes the optical element being provided in the form of an etalon that is positioned in the beam path of the source beam, the etalon including a first etalon surface and a spaced apart second etalon surface; and further comprising the source beam impinging on the first etalon surface splitting the source beam into the first guide beam and the second guide beam; and

wherein the step of splitting further includes the first etalon surface including a first region having a first reflectivity, and a second region having a second reflectivity that is different than the first reflectivity; and further comprising the source beam impinging on the first region of the first etalon surface reflecting a first portion of the source beam as the first guide beam, and transmitting a second portion of the source beam as the second guide beam that reflects off of the second etalon surface before being transmitted through the second region of the first etalon surface.

4 . The method of claim 3 wherein the step of splitting includes the first region of the first etalon surface including a fifty percent reflective coating, the second region of the first etalon surface including an anti-reflective coating, and the second etalon surface including a highly-reflective coating.

5 . The method of claim 3 wherein the steps of directing the first guide beam and directing the second guide beam include the etalon directing the first guide beam and the second guide beam so that they are spaced apart and parallel to one another as they are directed away from the etalon; and wherein a separation between the first guide beam and the second guide beam is determined based at least in part on an incident angle of the source beam impinging on the first region of the first etalon surface, and a thickness of the etalon.

6 . The method of claim 3 wherein the step of splitting includes the etalon being wedge-shaped such that the first region of the first etalon surface is positioned at an angle relative to the second region of the first etalon surface.

7 . A method for treating a vascular lesion within or adjacent to a vessel wall within a body of a patient by generating a plasma that creates pressure waves adjacent to the vascular lesion, the method comprising the steps of:

generating light energy in the form of a source beam with a single light source;

positioning a multiplexer in a beam path of the source beam, the multiplexer including an optical element;

receiving the source beam with the optical element of the multiplexer;

splitting the source beam into a first guide beam and a second guide beam with the optical element of the multiplexer;

directing the first guide beam to a first light guide with the multiplexer; and

directing the second guide beam to a second light guide with the multiplexer;

wherein the step of splitting includes the optical element being provided in the form of an etalon that is positioned in the beam path of the source beam, the etalon including a first etalon surface and a spaced apart second etalon surface; and further comprising the source beam impinging on the first etalon surface splitting the source beam into the first guide beam and the second guide beam; and

wherein the step of splitting includes the multiplexer further including a second etalon that is stacked adjacent to the first etalon.

8 . A method for treating a vascular lesion within or adjacent to a vessel wall within a body of a patient by generating a plasma that creates pressure waves adjacent to the vascular lesion, the method comprising the steps of:

generating light energy in the form of a source beam with a single light source;

positioning a multiplexer in a beam path of the source beam, the multiplexer including an optical element;

receiving the source beam with the optical element of the multiplexer;

splitting the source beam into a first guide beam and a second guide beam with the optical element of the multiplexer;

directing the first guide beam to a first light guide with the multiplexer; and

directing the second guide beam to a second light guide with the multiplexer;

wherein the step of positioning includes the multiplexer further including a multiplexer stage and the optical element being provided in the form of at least one diffractive optical element that is mounted on the multiplexer stage;

wherein the step of splitting includes one of the at least one diffractive optical element receiving the source beam from the light source and separating the source beam from the light source into at least the first guide beam that is directed to the first light guide and the second guide beam that is directed to the second light guide; and

wherein each of the at least one diffractive optical element alternatively receives the source beam from the light source and separates the source beam from the light source into a different pattern of individual guide beams including at least the first guide beam and the second guide beam.

9 . The method of claim 8 further comprising the step of moving the multiplexer stage with a stage mover so that each of the at least one diffractive optical element is alternatively positioned in the beam path of the source beam from the light source.

10 . The method of claim 1 wherein the step of receiving the pulses of light energy includes the redirector redirecting the source beam by approximately 90 degrees toward the coupling optics.

11 . The method of claim 1 further comprising the steps of positioning an optical element in the beam path of the source beam between the light source and the multiplexer; and redirecting the source beam from the light source with the optical element so that the source beam is directed toward the multiplexer.

12 . The method of claim 11 wherein the step of redirecting the source beam includes redirecting the source beam from the light source by approximately 90 degrees with the optical element so that the source beam is directed toward the multiplexer.

13 . The method of claim 1 wherein the step of generating includes the light source including a laser.

14 . The method of claim 1 wherein the steps of focusing the first guide beam and focusing the second guide beam include simultaneously focusing the first guide beam onto the first light guide and the second guide beam onto the second guide.

15 . The method of claim 1 wherein the steps of focusing the first guide beam and focusing the second guide beam include sequentially focusing the first guide beam onto the first light guide and the second guide beam onto the second guide.

16 . The method of claim 2 wherein the step of positioning includes the optical element being an imperfect parallelogram.

17 . The method of claim 2 wherein the step of generating includes the light source including a laser.

18 . The method of claim 3 wherein the step of generating includes the light source including a laser.

19 . The method of claim 7 wherein the step of generating includes the light source including a laser.

20 . The method of claim 8 wherein the step of generating includes the light source including a laser.

Assignments (2)

Continuity (3)

References Cited (400)