Anti-scalping pharmaceutical packaging film
A film for packaging a product that has a pharmaceutical active agent includes a product-contacting sealing layer. The product contacting layer includes at least 90 wt. % of an ethylene norbornene copolymer having a glass transition temperature in a range from 50° C. to 110° C. The pharmaceutical active agent comprises a Hansen Solubility Parameter for the product-contacting sealing layer of 0.5 or greater.
1. A packaged pharmaceutical product comprising:
a multilayer film, and a product comprising a pharmaceutical active agent;
wherein the multilayer film comprises:
(a) a drug contact layer having at least 90 wt. % of an ethylene norbornene copolymer having a glass transition temperature of from 65° C. to 110° C.;
(b) a polyolefin bulk layer;
(c) a first intermediate adhesive layer;
(d) an oxygen barrier layer having an oxygen transmission rate of less than 0.01 cm 3 /100 inches 2 /24 hours at 1 atmosphere and 23° C.;
(e) a second intermediate adhesive layer; and
(f) an exterior protective layer comprising a material selected from the group consisting of paper, oriented polyester, amorphous polyester, polyamide, polyolefin, nylon, polypropylene and blends thereof,
and has a water vapor transmission rate (WTVR) of less than 0.01 g/100 square inches per 24 hours at 23° C. and 1 atmosphere; and
the pharmaceutical active agent comprises a Hansen Solubility Parameter for the drug contact layer of 0.5 or greater.
2. The packaged pharmaceutical product according to claim 1 , wherein:
the multilayer film is formed into a flexible container; and
a transdermal patch is sealed within the container.
3. The packaged pharmaceutical product according to claim 2 , wherein the patch is a nicotine or fentanyl drug delivery patch.
4. A packaged pharmaceutical product according to claim 1 , wherein the pharmaceutical active agent is selected from the group consisting of nicotine, lidocaine, estradiol, clonidine, ethinyl estradiol, buprenorphine, granisitron, and scopolamine.
5. A packaged pharmaceutical product comprising:
a drug resistant, flexible, multilayer packaging film comprising a drug contact layer having a nylon blend composition, wherein the film is formed into a flexible container; and
a product comprising a pharmaceutical active agent, wherein the pharmaceutical active agent is in contact with the drug contact layer of the film and comprises a Hansen Solubility Parameter for the drug contact layer of 0.5 or greater.
6. The packaged pharmaceutical product according to claim 5 , wherein the drug contact layer consists essentially of the nylon blend.
7. The packaged pharmaceutical product according to claim 5 , wherein the pharmaceutical active agent is selected from the group consisting of nicotine, lidocaine, estradiol, clonidine, ethinyl estradiol, buprenorphine, granisitron, and scopolamine.
8. The packaged pharmaceutical product according to claim 5 , wherein the product comprising the pharmaceutical active agent comprises a transdermal patch comprising the pharmaceutical active agent, wherein the patch is a nicotine or fentanyl drug delivery patch.