Self-expanding devices and methods therefor
Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
1. A method of treating a patient, the method comprising:
delivering a self-supported, wire-like expandable device to an ear region of the patient, wherein the expandable device is configured to expand from a first compressed configuration to a second expanded configuration against tissue,
wherein the expandable device comprises one or more biodegradable polymer filaments formed into a repeating diamond-shaped pattern, and wherein the expandable device is configured to release a drug.
2. The method of claim 1 , wherein delivering the expandable device comprises delivering the expandable device to a Eustachian tube of the patient.
3. The method of claim 1 , wherein delivering the expandable device comprises delivering the expandable device to a middle ear region of the patient.
4. The method of claim 3 , wherein delivering the expandable device comprises delivering the expandable device to a tympanic cavity of the patient.
5. The method of claim 1 , wherein the one or more biodegradable polymer filaments comprises at least two biodegradable polymer filaments.
6. The method of claim 5 , wherein the at least two biodegradable polymer filaments are joined.
7. The method of claim 5 , wherein the at least two biodegradable polymer filaments are interwoven.
8. The method of claim 5 , wherein the at least two biodegradable polymer filaments are joined by bonding, welding, mechanical fastening, or a combination thereof.
9. The method of claim 1 , wherein the expandable device defines a wire-like tube when disposed in an expanded configuration.
10. The method of claim 1 , wherein at least one of the one or more biodegradable polymer filaments is at least partially coated with a drug eluting layer comprising the drug.
11. The method of claim 10 , wherein the drug comprises a therapeutic agent comprising one or more selected from the group consisting of: anti-inflammatory agents, anti-allergens, anticholinergic agents, antihistamines, anti-infectives, anti-platelet agents, anti-coagulants, antithrombic agents, anti-scarring agents, anti-proliferative agents, chemotherapeutic agents, antineoplastic agents, decongestants, healing promoting agent, vitamins, hypersomolar agents, immunomodulators, and immunosuppressive agents.
12. The method of claim 11 , wherein the therapeutic agent comprises an anti-inflammatory agent selected from the group consisting of 21-acetoxypregnenolone, alclometasone, algestone, amcinonide, beclomethasone, betamethasone, budesonide, chloroprednisone, clobetasol, clobetasone, clocortolone, cloprednol, corticosterone, cortisone, cortivazol, deflazacort, desonide, desoximetasone, dexamethasone, diflorasone, diflucortolone, difluprednate, enoxolone, fluazacort, flucloronide, flumethasone, flunisolide, fluocinolone acetonide, fluocinonide, fluocortin butyl, fluocortolone, fluorometholone, fluperolone acetate, fluprednidene acetate, fluprednisolone, flurandrenolide, fluticasone propionate, formocortal, halcinonide, halobetasol propionate, halometasone, halopredone acetate, hydrocortamate, hydrocortisone, loteprednol etabonate, mazipredone, medrysone, meprednisone, methylprednisolone, mometasone furoate, paramethasone, prednicarbate, prednisolone, prednisolone 25-diethylamino-acetate, prednisolone sodium phosphate, prednisone, prednival, prednylidene, rimexolone, tixocortol, triamcinolone, triamcinolone acetonide, triamcinolone benetonide, triamcinolone hexacetonide, COX inhibitors, and any derivatives thereof.
13. The method of claim 1 , wherein the expandable device is configured to release the drug over a period of time between about 5 days to about 120 days.
14. The method of claim 1 , wherein the expandable device is configured to release the drug at a daily dosage of about 500 μg or less per day.
15. The method of claim 1 , wherein the expandable device is configured to release a first amount of the drug during a first period of time, and release a second amount of the drug during a second period of time, wherein the second amount is different from the first amount.
16. The method of claim 15 , wherein the first period of time is one week.
17. The method of claim 1 , wherein at least one of the one or more biodegradable polymer filaments comprises poly(lactide-co-glycolide).
18. The method of claim 17 , wherein a molar percent of lactide in the at least one biodegradable polymer filament is between about 0% and about 50%.
19. The method of claim 1 , further comprising releasing one or more anesthetic drugs to the ear canal.
20. The method of claim 19 , wherein releasing one or more anesthetic drugs comprises releasing one or more anesthetic drugs during delivery of the expandable device.
21. The method of claim 1 , wherein the one or more biodegradable polymer filaments are wound into a series of diamond shapes each including a peak and a valley, and
wherein a distal end of the expandable device is defined by the peaks of each of the diamond shapes and a proximal end of the expandable device is defined by the valleys of each of the diamond shapes.