Treatments and prevention of opioid neonatal abstinence syndrome
Disclosed is a method for reducing or preventing fetal opioid dependence in a drug dependent or opioid tolerant pregnant subject. The method involves administering to the pregnant subject a composition comprising an opioid antagonist in an amount effective to reduce or prevent fetal opioid dependence, wherein the opioid antagonist a) is orally available or delivered systemically and reaches the circulation of the pregnant subject, b) is substantially excluded from the subject's brain by the blood brain barrier, and c) penetrates the placenta and enters the fetal brain. The method also includes administering the opioid antagonist to the neonate in increasing amounts to facilitate weaning the neonate from continued opioid maintenance.
1. A method for treating or preventing neonatal withdrawal or abstinence syndrome, comprising:
prenatally administering to a drug dependent or opioid tolerant pregnant subject receiving opioid therapy or maintenance a first composition comprising an opioid antagonist in an amount effective to reduce or prevent the neonatal withdrawal or abstinence syndrome, wherein the opioid antagonist is a neutral antagonist to a μ-opioid receptor; and
postnatally administering to a drug dependent or opioid tolerant infant subject a second composition comprising the opioid neutral antagonist in increasing amounts effective to facilitate weaning the infant from continued opioid maintenance administered when neonatal abstinence is observed.
2. The method of claim 1 , wherein the opioid antagonist comprises 6β-naltrexol.
3. The method of claim 1 , wherein the opioid antagonist is delivered in two daily sub-doses.
4. The method of claim 1 , wherein the opioid antagonist is delivered in a daily dosage range from about 0.1 mg to about 100 mg.
5. The method of claim 1 , wherein the opioid antagonist is comprised in a sustained drug release formulation.
6. The method of claim 1 , wherein the opioid antagonist is orally available.
7. The method of claim 1 , further comprising administering a palliative therapy to the pregnant subject and/or the infant subject.
8. The method of claim 1 , further comprising administering a 5-HT antagonist to the pregnant subject and/or the infant subject.
9. The method of claim 8 , wherein the 5-HT antagonist is ondansetron.
10. The method of claim 1 , wherein the opioid antagonist reaches fetal circulation in sufficient amounts to reduce or reverse fetal opioid dependence.