Intraocular drug delivery platform
An intraocular drug delivery platform for use with an intraocular lens assembly. The platform includes a ring and haptics to maintain the ring in position in the capsular bag, compartments on the anterior surface of the ring for accommodating a drug eluting matrix or other drug mass, and a skirt extending posteriorly from the posterior surface of the ring to constrain movement, including lateral or inferior/superior movement, of the intraocular lens relative to the ring.
1. An intraocular drug delivery platform for use with an intraocular lens (IOL), comprising:
a flat ring comprising an anterior surface, a posterior surface opposite the anterior surface, and a central aperture formed by the ring,
a first haptic coupled to and extending outwards from the ring,
a second haptic coupled to and extending outwards from the ring,
a first drug eluting mass comprising a therapeutic agent coupled to the anterior surface of the ring,
a second drug eluting mass comprising the therapeutic agent coupled to the anterior surface of the ring and positioned directly opposite of the first drug eluting mass,
a skirt extending posteriorly from the posterior surface of the ring and partially or fully circumscribing the central aperture, and
an intraocular lens (IOL) configured to be retained in a position by the intraocular drug delivery platform, the OIL comprising a first lens haptic and a second lens haptic,
wherein the skirt comprises an inner diameter sized and configured to retain the OIL within the skirt.
2. The intraocular drug delivery platform of claim 1 , wherein the first and second drug eluting masses are each in the form of a slab.
3. The intraocular drug delivery platform of claim 1 , wherein the first and second drug eluting masses each include a membrane to control a rate of elution of the therapeutic agent.
4. The intraocular drug delivery platform of claim 3 , wherein the membrane is a semi-permeable membrane.
5. The intraocular drug delivery platform of claim 1 , wherein the therapeutic agent of the first drug eluting mass is dispersed within a first matrix of the first drug eluting mass, and the therapeutic agent of the second drug eluting mass is dispersed within a second matrix of the second drug eluting mass.
6. The intraocular drug delivery platform of claim 5 , wherein the first matrix is a silicone matrix, and wherein the second matrix is a silicone matrix.
7. The intraocular drug delivery platform of claim 1 , wherein the therapeutic agent comprises bimatoprost.
8. The intraocular drug delivery platform of claim 7 , wherein the bimatoprost is in a crystalline form.
9. The intraocular drug delivery platform of claim 1 , wherein the ring further comprises a first compartment and a second compartment, the first drug eluting mass being positionable in the first compartment, and the second drug eluting mass being positionable in the second compartment.
10. The intraocular drug delivery platform of claim 9 , wherein the first compartment and the second compartment extend anteriorly from the anterior surface of the ring.